Image quality enhancement for LED-based photoacoustic imaging

Chandramoorthi, Sowmiya; Singh, Mithun Kuniyil Ajith; Thittai, Arun K.

doi:10.1117/12.2579159

Cited by 4 publications

(3 citation statements)

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“…Results from our experiments give a direct confirmation about the potential of AcousticX in microvascular health assessment. However, in future, improvements in imaging depth by making use of optimized acoustic detection, smart reconstruction algorithms, and post-processing techniques may help to translate this system into clinical use [25][26][27][28][29][30][31][32] .…”

Section: Imaging Blood Oxygen Saturationmentioning

confidence: 99%

LED-based photoacoustic imaging: a point-of-care solution for microvascular health assessment

Kuniyil Ajith Singh,

Sato,

Ichihashi

et al. 2024

Photons Plus Ultrasound: Imaging and Sensing 2024

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Accurate assessment of microvasculature and oxygen saturation is vital for diagnosing and monitoring diseases, including cancer. However, the current clinical need for point-of-care (POC), non-invasive, and cost-effective imaging approaches remains unmet. Photoacoustic imaging, offering natural blood contrast, holds potential for high-resolution vascular imaging. Yet, the requirement for bulky and expensive lasers impedes its clinical translation, particularly in resource-limited settings. Recent advances in using high-power LED arrays for photoacoustic imaging are promising due to their portability, affordability, and ease-of-use in clinical settings. In this work, we demonstrate the potential of LED-based photoacoustic imaging for microvascular health assessment through in vivo human volunteer imaging. Real-time 2D and 3D experiments evaluated LED-based photoacoustic imaging in assessing vascular density, arterial distensibility, and blood oxygen saturation with high resolution. Our results confirm that LED-based photoacoustic imaging may serve as an invaluable POC tool for microvascular health assessment in resource-limited settings. The affordability and simplicity of LED arrays present a compelling alternative to laser-based approaches, expanding accessibility in clinical practice. This advancement has the potential to enhance early disease detection and treatment monitoring, particularly in areas with limited access to sophisticated imaging technologies.

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Section: Imaging Blood Oxygen Saturationmentioning

confidence: 99%

LED-based photoacoustic imaging: a point-of-care solution for microvascular health assessment

Kuniyil Ajith Singh,

Sato,

Ichihashi

et al. 2024

Photons Plus Ultrasound: Imaging and Sensing 2024

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“…Detection of sO2 non-invasively at microvasculature level will undoubtedly be interesting for multiple preclinical and clinical imaging applications. However, in future, improvements in imaging depth by making use of optimized acoustic detection 32 , improved light delivery strategies 33 , artifact reduction techniques 34,35 , deep-learning enhanced reconstruction algorithms 36,37,38 , and novel post-processing techniques 39,40 may help to accelerate the translation of this system into clinical use. Also, it will be important to explore fluence-compensated oxygen saturation estimation for obtaining more quantitative information.…”

Section: Real-time Imaging Of Tail-vein So2 Using Acousticxmentioning

confidence: 99%

Oxygen saturation imaging using dual-wavelength LED-based photoacoustics

Singh¹,

Sato²,

Tsunoi³

et al. 2023

Photons Plus Ultrasound: Imaging and Sensing 2023

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Since hypoxia is an early marker for cancer and several microvascular disorders, imaging oxygen saturation with high resolution has profound importance in multiple preclinical and clinical imaging studies. In this work, we demonstrate the potential of dual-wavelength (690/850 nm) LED-based photoacoustic imaging in high resolution real-time oxygen saturation imaging in vivo. We performed two live rat imaging experiments in which the oxygen saturation of the bloodvessels in the left hindlimb was imaged for 20 seconds while the animal was breathing pure nitrogen gas to induce hypoxia. For a comparison, we continuously monitored the oxygen level using a pulse oximeter connected to the forelimb. In another experiment, we performed imaging of oxygen saturation changes in the tail vein of the rat while hypoxia was induced over the period of 40 seconds. In this case also, pulse oximeter readings were recorded for a comparison. In all the experiments, photoacoustic-based oxygen saturation values measured over time followed the same trend as the reference values provided by the pulse oximeter. Also, our two wavelength LED-based photoacoustic imaging approach was found to be sensitive even for 3% change in oxygen saturation. Results give a direct confirmation about the potential of LED-based photoacoustic imaging in detection of oxygen saturation with high spatio-temporal resolution, making it an ideal tool for hypoxia detection in longitudinal preclinical and clinical imaging studies.

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“…However, in future, it is of paramount importance to improve the imaging depth and spatial resolution for translating 3D LED-PA imaging to clinics. In this regard, it will be important to explore acoustic detection optimization, 29 new illumination strategies, 30 artifact reduction techniques, 31,32 smart reconstruction algorithms, [33][34][35] and post-processing techniques 36,37 to enhance the image quality of LED-based PA imaging and accelerate its clinical translation. Also, it will be of great interest in multiple clinical applications to use two-wavelength LED arrays and generate 3D PA/US MIP images with combined vascular, functional, and structural information from a single acquisition.…”

Section: New Colormaps To Display 3d Led-based Pa Imagesmentioning

confidence: 99%

Improving 3D imaging capability of LED-based photoacoustic imaging for high resolution human vascular imaging applications

Singh¹,

Sato²,

Ichihashi³

et al. 2023

Photons Plus Ultrasound: Imaging and Sensing 2023

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Visualizing blood vessel networks in 3D is helpful in many superficial vascular imaging applications. We previously reported the feasibility of LED-based photoacoustic imaging in visualizing human vasculature in 3D by linear translation of combined photoacoustic/ultrasound imaging probe. In this work, we improved this 3D imaging functionality by 1) automatic removal of skin PA signal in different 2D slices by ultrasound-based lineation , 2) encoding depth information with different colors and 3)improving the grayscale and hot color maps. All these new features were implemented in the system software and we validated these using phantom and human in vivo imaging experiments. Results demonstrate that the newly implemented features significantly improved the 3D imaging capability in our LED-based photoacoustic and ultrasound imaging system. We believe that the improved 3D imaging functionality in the system will be potentially useful for multiple preclinical and clinical applications in which the visualization of vasculature in 3D is a prerequisite.

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Image quality enhancement for LED-based photoacoustic imaging

Cited by 4 publications

References 0 publications

LED-based photoacoustic imaging: a point-of-care solution for microvascular health assessment

LED-based photoacoustic imaging: a point-of-care solution for microvascular health assessment

Oxygen saturation imaging using dual-wavelength LED-based photoacoustics

Improving 3D imaging capability of LED-based photoacoustic imaging for high resolution human vascular imaging applications

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