It is common to characterize a single sample using multiple different microscopy methods that have variable scales, rotation, and translation. Correlating or registering hyperspectral images of two-dimensional materials is particularly difficult due to the lack of keypoints on un-patterned substrates. Strain/doping maps can assist by creating these keypoints. Registration of these images allows for multimodal analysis from these various instruments by aligning multiple images into a single coordinate space. This is done by Hough transformations and arbitrary resolution definitions to generate a new coordinate frame where spatial information may be preserved and correlated on a pixel by pixel basis.