The sharpening is a scheme applied to highlight the intensity transitions in an image. This enhancement increases edge acutance and significantly improves the overall sharpness of processed images. Image sharpening is of enormous importance in medicine for diagnosis. Noise overshoot and over-sharpening effects occur in classical sharpening algorithms. The adaptive approach skips the noise producing a better sharpening scheme. Abrupt pixel value changes, if adequately emphasized, can be utilized effectively in the sharpening process. Since the residual image contains noise and edges, the bigger the filter size the greater the number of edges left in the residual image. Two residual images are produced first with different filter sizes. There is a relationship between these two residuals. A simple regression and standard deviation (±σ) is measured using these residuals. This linear equation is an expectation and the standard deviation is the difference between two residuals. One deviation (±σ) is proposed as the threshold. The points contained edges if the residual value is measured using a larger sized filter off ± σ than those residual using a smaller sized filter. A sensitive filter is adaptively applied to the image on those locations. It has been demonstrated that the proposed approach yields better results than the global filter as well as previous work on the P calculation results. A sharpening scheme without latent image noise amplification is useful for pattern recognition and machine-learning. In the future this scheme will be used to pre-process image segmentation.