Imagen de PET/TC con 18F-FDG en la enfermedad de Castleman

Delgado, A.; Mesa, José Marı́a; Guayambuco, S.; Rodríguez, T.; Fernández, I. Fernández; Rodeño, E.

doi:10.1016/j.remn.2015.10.001

Cited by 1 publication

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“…There are few reports on CT imaging of the vessels which surround or enter nodules of the two conditions. Although previous CT studies have focused on the degree of enhancement to distinguish CD from lymphoma [ 4 , 16 , 23 , 24 ], the enhancement extent of the two entities sometimes overlaps. In our study, 5 (14.7%) cases with CD and 43 (78.2%) cases with lymphoma demonstrated moderate enhancement on initial contrast-enhanced CT.…”

Section: Discussionmentioning

confidence: 99%

Castleman disease versus lymphoma in neck lymph nodes: a comparative study using contrast-enhanced CT

Wang

Yang

et al. 2018

Cancer Imaging

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BackgroundThe purpose of this study was to determine the contrast-enhanced CT characteristics for differentiating between Castleman disease (CD) and lymphoma in neck lymph nodes.MethodsThis retrospective study evaluated the number (solitary or multiple), strength of contrast-enhancement, type of contrast-enhancement, surrounding vessels, contrast-enhanced Hounsfield unit (HU) values, and anatomical distributions of lymph nodes in 34 patients with confirmed CD and 55 patients with newly diagnosed untreated lymphoma. Independent t-tests, receiver operating characteristic (ROC) curve analysis, and chi-square tests were used to evaluate the variables and CT features.ResultsSeveral significant differences were found between CD and lymphoma. The interval between first contrast-enhanced CT and biopsy/surgery was significantly longer in the CD group (mean 72 ± 105 days, median 60 days) than in the lymphoma patients (mean 30 ± 2 days, median 12 days; p = 0.015). The lymphoma patients presented significantly more often with fatigue and fever (p = 0.023 and p = 0.016 respectively) than did the CD subjects. HU values of nodules after enhancement were significantly higher in the CD patients than in the lymphoma patients. In cases involving multiple lymph nodes, in all the CD cases, all affected nodes were located in only the left or right side of the neck, not bilaterally. ROC analysis showed a significant difference in contrast-enhanced CT attenuation values between lymphoma and CD (p < 0.001, area under the curve = 0.954), with a cut-off value of 92.5 HU. We constructed a decision tree according to these imaging characteristics.ConclusionsContrast-enhanced CT can be useful for differentiating between CD and lymphoma.

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