Imaging and tracing the pattern of adult ovarian angiogenesis implies a strategy against female reproductive aging

Xu, Xueqiang; Mu, Lu; Li, Lingyu; Liang, Jing; Zhang, Shuo; Jia, Longzhong; Yang, Xuebing; Dai, Yanwei; Zhang, Jiawei; Wang, Yibo; Niu, Shudong; Xia, Guoliang; Yang, Yunlong; Zhang, Yan; Cao, Yihai; Zhang, Hua

doi:10.1126/sciadv.abi8683

Cited by 19 publications

(9 citation statements)

References 63 publications

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“…In these studies, the density of the capillaries increased significantly with the maturation of the follicles. Similarly, there was a greater density of blood vessels in the dominant follicle during proestrus than in other phases of the estrus cycle (Feng et al, 2017, Xu et al, 2022).…”

Section: Follicular Developmentmentioning

confidence: 95%

“…Moreover, VEGF treatment increased the diameter of secondary bovine follicles in vitro (Araújo et al, 2014). On the other hand, VEGF inhibition reduced the growth of primary and secondary follicles in ovaries from 3‐ to 4‐day‐old rats (McFee et al, 2009), and increased the number of primordial follicles at 8 weeks augmenting the life span of growing follicles (Xu et al, 2022). These results suggest that VEGF inhibition prevents the activation of primordial follicles and extends the life span of the follicles saving the ovarian reserve in the long term and delaying ovarian senescence (Feng et al 2017; Xu et al, 2022).…”

Section: Vegf System and Follicular Growthmentioning

confidence: 99%

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The vascular endothelial growth factor (VEGF) system as a key regulator of ovarian follicle angiogenesis and growth

Guzmán¹,

Hernández‐Coronado²,

Gutiérrez

et al. 2023

Molecular Reproduction Devel

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The vascular endothelial growth factor‐A (VEGFA) system is a complex set of proteins, with multiple isoforms and receptors, including both angiogenic (VEGFxxx, VEGFR2) and antiangiogenic members (VEGFxxxb, VEGFR1 and soluble forms of VEGFR). The members of the VEGF system affect the proliferation, survival, and migration of endothelial and nonendothelial cells and are involved in the regulation of follicular angiogenesis and development. The production of VEGF by secondary follicles stimulates preantral follicular development by directly affecting follicular cells and promoting the acquisition of the follicular vasculature and downstream antrum formation. Additionally, the pattern of expression of the components of the VEGF system may provide a proangiogenic milieu capable of triggering angiogenesis and stimulating follicular cells to promote antral follicle growth, whereas, during atresia, this milieu becomes antiangiogenic and blocks follicular development.

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Section: Follicular Developmentmentioning

confidence: 95%

Section: Vegf System and Follicular Growthmentioning

confidence: 99%

The vascular endothelial growth factor (VEGF) system as a key regulator of ovarian follicle angiogenesis and growth

Guzmán¹,

Hernández‐Coronado²,

Gutiérrez

et al. 2023

Molecular Reproduction Devel

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show abstract

“…Vascular networks are essential for follicle growth, nutrient exchange, and peptide hormone transport in vivo. As follicles mature, increasing levels of VEGF are expressed by granulosa and theca cells, stimulating an independent vascular network around the follicle to support its development [ 110-112 ]. Therefore, designing materials that promote angiogenesis is essential for the development of a bioprosthetic ovary.…”

Section: Just Off the Block: The Bioprosthetic Ovary—translational Ef...mentioning

confidence: 99%

Restoring Ovarian Fertility and Hormone Function: Recent Advancements, Ongoing Efforts and Future Applications

Tsui,

McDowell,

Laronda

2024

Journal of the Endocrine Society

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The last twenty years have seen significant improvements in fertility and hormone preservation and restoration technologies for a growing number of cancer survivors. However, further advancements are required to fill the gaps for those who cannot use current technologies or to improve the efficacy and longevity of current fertility and hormone restoration technologies. Ovarian tissue cryopreservation (OTC) followed by ovarian tissue transplantation (OTT) offers those unable to undergo ovarian stimulation for egg retrieval and cryopreservation an option that restores both fertility and hormone function. However, those with metastatic disease in their ovaries are unable to transplant this tissue. Therefore, new technologies to produce good quality eggs and restore long-term cyclic ovarian function are being investigated and developed to expand options for a variety of patients. This mini-review describes current and near future technologies including in vitro maturation, in vitro follicle growth and maturation, bioprosthetic ovaries, and stem cell applications in fertility restoration research by their proximity to clinical application.

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“…Nevertheless, robust angiogenesis in ovarian follicles and corpus luteum (CL) was recently uncovered with an imaging system, confirming that the generation of new blood vessels was pivotal to guaranteeing a sufficient supply of nutrients and hormones during follicle maturation and development ( 130 ). It was reported that the administration of axitinib, the blocker of angiogenesis, decreased ovarian follicle consumption, postponed ovarian aging, and extended female reproductive longevity by suppressing follicle recruiting and development ( 130 ). It implied a potential clinical approach to pause lesion progression and delay ovarian aging in patients with OMA.…”

Section: The Mechanisms Of Oma Per Se Leading To O...mentioning

confidence: 99%

Impacts of endometrioma on ovarian aging from basic science to clinical management

Tan

Xue

et al. 2023

Front. Endocrinol.

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Endometriosis is a common reproductive disorder characterized by the presence of endometrial implants outside of the uterus. It affects ~1 in 10 women of reproductive age. Endometriosis in the ovary, also known as endometrioma (OMA), is the most frequent implantation site and the leading cause of reproductive failure in affected women. Ovarian aging is one of the characteristic features of OMA, however its underlying mechanism yet to be determined. Accumulated evidence has shown that pelvic and local microenvironments in women with OMA are manifested, causing detrimental effects on ovarian development and functions. Whilst clinical associations of OMA with poor ovarian reserve, premature ovarian insufficiency, and early menopause have been reported. Moreover, surgical ablation, fenestration, and cystectomy of OMA can further damage the normal ovarian reservoir, and trigger hyperactivation of primordial follicles, subsequently resulting in the undesired deterioration of ovarian functions. Nevertheless, there is no effective treatment to delay or restore ovarian aging. This review comprehensively summarised the pathogenesis and study hypothesis of ovarian aging caused by OMA in order to propose potential therapeutic targets and interventions for future studies.

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Imaging and tracing the pattern of adult ovarian angiogenesis implies a strategy against female reproductive aging

Abstract: Unique model of adult ovarian angiogenesis implies a strategy to extend female reproductive life span.

Cited by 19 publications

References 63 publications

The vascular endothelial growth factor (VEGF) system as a key regulator of ovarian follicle angiogenesis and growth

The vascular endothelial growth factor (VEGF) system as a key regulator of ovarian follicle angiogenesis and growth

Restoring Ovarian Fertility and Hormone Function: Recent Advancements, Ongoing Efforts and Future Applications

Impacts of endometrioma on ovarian aging from basic science to clinical management

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