Imaging anisotropic and viscous properties of breast tissue by magnetic resonance‐elastography

Sinkus, Ralph; Tanter, Mickaël; Catheline, Stéfan; Lorenzen, J.; Kuhl, Christiane K.; Sondermann, Elke; Fink, Mathias

doi:10.1002/mrm.20355

Cited by 337 publications

(319 citation statements)

References 26 publications

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“…For reducing noise, numerical derivatives were calculated by 3D gradients according to Anderssen and Hegland [29] using a twopixel symmetric window in three dimensions [30]. The resulting strain components of the wave field (derivatives of the three Cartesian components of the displacement field) were used to calculate the curl field, as has been established in 3D MRE for suppressing volumetric strain [31]. The curl components C 1 , C 2 and C 3 are defined as follows: Fig.…”

Section: Data Processingmentioning

confidence: 99%

Patient-Activated Three-Dimensional Multifrequency Magnetic Resonance Elastography for High-Resolution Mechanical Imaging of the Liver and Spleen

Guo

Hirsch

Streitberger

et al. 2013

Fortschr Röntgenstr

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Purpose: To introduce a novel in-vivo three-dimensional multifrequency magnetic resonance elastography (3D-MMRE) method for high-resolution mechanical characterization of the liver and spleen. Materials and Methods: Ten healthy volunteers were examined by abdominal single-shot 3D-MMRE using a novel patient-activated trigger system with respiratory control. 10 contiguous slices with 2.5?mm cubic voxel resolution, 3 wave components, 8 time steps, and 2 averages were acquired at 7 mechanical excitation frequencies from 30 to 60?Hz. The total imaging time was approximately 15?min. For postprocessing, multifrequency dual elasto-visco (MDEV) inversion was used to calculate high-resolution mechanical parameter maps of the abdomen including the liver and spleen. Results: Two parameters maps were generated from each image slice to capture the magnitude and the phase angle of the complex shear modulus. Both parameters depicted the mechanical structures of the abdomen with unprecedented high spatial resolution. Spatially averaged group mean values of the liver and spleen are 1.27???0.17 kPa and 2.01???0.69 kPa, indicating a significantly higher asymptomatic stiffness of the spleen compared to the liver. Conclusion: Patient-activated respiratory-gated 3D-MMRE combined with MDEV inversion provides highly resolved mechanical maps of the liver and spleen that are superior to previous elastograms measured by abdominal MRE. Citation Format: ??Guo J, Hirsch S, Streitberger KJ et?al. Patient-Activated Three-Dimensional Multifrequency Magnetic Resonance Elastography for High-Resolution Mechanical Imaging of the Liver and Spleen. Fortschr R?ntgenstr 2014; 186: 260???266

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Section: Data Processingmentioning

confidence: 99%

Patient-Activated Three-Dimensional Multifrequency Magnetic Resonance Elastography for High-Resolution Mechanical Imaging of the Liver and Spleen

Guo

Hirsch

Streitberger

et al. 2013

Fortschr Röntgenstr

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“…MRE provides quantitative stiffness information and enables, in a way, palpation by imaging, even of deep-lying tissues. Several studies have shown the potential of MRE for quantitatively depicting the elastic properties of breast tissue in vivo, and have revealed high shear elasticity in breast tumor tissue and a remarkably large dynamic range to discriminate benign from malignant lesions (179)(180)(181)(182).…”

Section: Mri Elastography and The Mechanical Properties Of Musclementioning

confidence: 99%

Dynamic MRS and MRI of skeletal muscle function and biomechanics

et al. 2006

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MR is a powerful technique for studying the biomechanical and functional properties of skeletal muscle in vivo in health and disease. This review focuses on 31 P, 1 H and 13 C MR spectroscopy for assessment of the dynamics of muscle metabolism and on dynamic 1 H MRI methods for non-invasive measurement of the biomechanical and functional properties of skeletal muscle. The information thus obtained ranges from the microscopic level of the metabolism of the myocyte to the macroscopic level of the contractile function of muscle complexes. The MR technology presented plays a vital role in achieving a better understanding of many basic aspects of muscle function, including the regulation of mitochondrial activity and the intricate interplay between muscle fiber organization and contractile function. In addition, these tools are increasingly being employed to establish novel diagnostic procedures as well as to monitor the effects of therapeutic and lifestyle interventions for muscle disorders that have an increasing impact in modern society.

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“…Thus, the plane of symmetry is spanned by the x-and z-axes, which define the corresponding axial elastic moduli (Young's moduli) E 1 ϭ E 2 and E 3 . The principal axis of symmetry (z) is assumed to be aligned with the long axis of the muscle so that it is parallel to the muscle fibers (12,24,27,30).…”

Section: Shear Waves In Transverse Isotropic Elastic and Incompressibmentioning

confidence: 99%

Shear wave group velocity inversion in MR elastography of human skeletal muscle

Papazoglou

Rump

Braun

et al. 2006

Magnetic Resonance in Med

108

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In vivo quantification of the anisotropic shear elasticity of soft tissue is an appealing objective of elastography techniques because elastic anisotropy can potentially provide specific information about structural alterations in diseased tissue. Here a method is introduced and applied to MR elastography (MRE) of skeletal muscle. With this method one can elucidate anisotropy by means of two shear moduli (one parallel and one perpendicular to the muscle fiber direction). The technique is based on group velocity inversion applied to bulk shear waves, which is achieved by an automatic analysis of wave-phase gradients on a spatiotemporal scale. The shear moduli are then accessed by analyzing the directional dependence of the shear wave speed using analytic expressions of group velocities in k-space, which are numerically mapped to real space. The method is demonstrated by MRE experiments on the biceps muscle of five volunteers, resulting in 5.5 ؎ 0.9 kPa and 29.3 ؎ 6.2 kPa (P < 0.05) for the medians of the perpendicular and parallel shear moduli, respectively. The proposed technique combines fast steadystate free precession (SSFP) MRE experiments and fully automated processing of anisotropic wave data, and is thus an interesting MRI modality for aiding clinical diagnosis. Magn Reson Med 56:489 -497, 2006.

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Imaging anisotropic and viscous properties of breast tissue by magnetic resonance‐elastography

Abstract: MR-elastography is a new technique

Cited by 337 publications

References 26 publications

Patient-Activated Three-Dimensional Multifrequency Magnetic Resonance Elastography for High-Resolution Mechanical Imaging of the Liver and Spleen

Patient-Activated Three-Dimensional Multifrequency Magnetic Resonance Elastography for High-Resolution Mechanical Imaging of the Liver and Spleen

Dynamic MRS and MRI of skeletal muscle function and biomechanics

Shear wave group velocity inversion in MR elastography of human skeletal muscle

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