Imaging biomarkers of outcome in the developing preterm brain

Ment, Laura R.; Hirtz, Deborah; Hüppi, Petra Susan

doi:10.1016/s1474-4422(09)70257-1

Cited by 353 publications

(321 citation statements)

References 127 publications

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“…We have recently analyzed diffuse lesions in a preterm fetal sheep model where animals survived for 1 or 2 weeks after global cerebral ischemia. This preparation generated a spectrum of WMI very similar to that observed from human autopsy studies, as well as a reduction in cerebral WM volume similar to that observed in preterm survivors [116][117][118]. We developed registration algorithms to analyze the histopathological features of 3 classes of MRI-defined lesions identified by ex vivo imaging at high field (12 Tesla) [46].…”

Section: Role Of High-field Mri To Define Pathological Features Of Wmimentioning

confidence: 87%

“…Although MRI is the optimal imaging modality to define WMI in preterm survivors [115][116][117][118], the histopathological features of MRI signal abnormalities have been mostly defined for WMI where periventricular leukomalacia predominates [64,[119][120][121][122][123]. With the pronounced shift to milder forms of human WMI defined by quantitative and diffusionweighted MRI, there is a need to define the cellular features of these lesions.…”

Section: Role Of High-field Mri To Define Pathological Features Of Wmimentioning

confidence: 99%

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The Instrumented Fetal Sheep as a Model of Cerebral White Matter Injury in the Premature Infant

et al. 2012

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Despite advances in neonatal intensive care, survivors of premature birth remain highly susceptible to unique patterns of developmental brain injury that manifest as cerebral palsy and cognitive-learning disabilities. The developing brain is particularly susceptible to cerebral white matter injury related to hypoxia-ischemia. Cerebral white matter development in fetal sheep shares many anatomical and physiological similarities with humans. Thus, the fetal sheep has provided unique experimental access to the complex pathophysiological processes that contribute to injury to the human brain during successive periods in development. Recent refinements have resulted in models that replicate major features of acute and chronic human cerebral injury and have provided access to complex clinically relevant studies of cerebral blood flow and neuroimaging that are not feasible in smaller laboratory animals. Here, we focus on emerging insights and methodologies from studies in fetal sheep that have begun to define cellular and vascular factors that contribute to white matter injury. Recent advances include spatially defined measurements of cerebral blood flow in utero, the definition of cellular maturational factors that define the topography of injury and the application of high-field magnetic resonance imaging to define novel neuroimaging signatures for specific types of chronic white matter injury. Despite the higher costs and technical challenges of instrumented preterm fetal sheep models, they provide powerful access to clinically relevant studies that provide a more integrated analysis of the spectrum of insults that appear to contribute to cerebral injury in human preterm infants.

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Section: Role Of High-field Mri To Define Pathological Features Of Wmimentioning

confidence: 87%

Section: Role Of High-field Mri To Define Pathological Features Of Wmimentioning

confidence: 99%

The Instrumented Fetal Sheep as a Model of Cerebral White Matter Injury in the Premature Infant

et al. 2012

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“…Obvious disruption of fiber tract organization around the lesions was seen on eigenvector maps. Periventricular cysts and similar disruption of WM tracts are a hallmark of cystic PVL seen in preterm infants leading to significant motor visual and cognitive impairment (3,16,39).…”

Section: Cystic Lesionsmentioning

confidence: 99%

“…Measurement of specific cerebral tissue volumes can be achieved by segmentation of the MRI into tissue types, on the basis of the contrast of the MRI (13). Several studies have assessed the developmental consequences of WM injury in the preterm infant on brain tissue volumes at term (14,15) and later in life (16), showing loss of WM and cortical volumes. Diffusion tensor imaging (DTI) is an advanced MRI technique widely used to explore brain microstructure development and injury (17)(18)(19)(20)(21).…”

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confidence: 99%

High-field diffusion tensor imaging characterization of cerebral white matter injury in lipopolysaccharide-exposed fetal sheep

et al. 2012

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Background:In gyrencephalic species such as sheep, precise anatomical and microstructural characterization of the consequences of fetal inflammation remains scarce. The goal of this study was to characterize changes in white matter (WM) structure using advanced magnetic resonance imaging (MRI) following lipopolysaccharide (LPS) exposure in the pretermequivalent fetal sheep. Methods: Preterm (0.7 gestation) fetal sheep received vehicle (Sham group) or LPS (LPS group), and fetal brains were collected 10 d later for subsequent ex vivo MRI. T 1 -weighted (T 1 W), T 2 -weighted (T 2 W), and diffusion tensor imaging (DTI) data were collected. results: Fetuses exposed to LPS exhibited reductions in WM volume and corpus callosum thickness at 10 d recovery. characteristic patterns of diffuse and focal WM lesions (necrosis or cysts) could be identified by various T 1 , T 2 , and DTI signal changes. conclusion: Fetal LPS exposure induces a pattern of injury characterized by diffuse and focal WM injury that closely reproduces that observed clinically in preterm infants. This work provides anatomical and microstructural MRI assessment, as well as histopathological correlates, of the consequences of LPS exposure in an animal model with a WM structure similar to that of the human brain. This work will help to further our understanding of MRI changes in preterm infants.

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“…Ainsi, celles-ci sont plus élevées aux premiers stades du développement car la majorité des processus de la matu- Ces dernières années, nombres d'études ont pointé du doigt une association entre syndrome métabolique et processus inflammatoire [4][5][6][7]. En effet, la prise de poids s'accompagne d'une inflammation des tissus et, plus particulièrement, du tissu adipeux blanc [6,[8][9][10]15]. Cette inflammation entraîne une production importante de facteurs pro-inflammatoires comme le TNF-α (tumor necrosis factor-a), le MCP1 (monocyte chemotactic protein 1) et une diminution des adi-…”

Section: Progrès Dans L'analyse Des Altérations Du Développement Céréunclassified

À propos du développement cérébral des prématurés

Rousseau

Girard

2013

Med Sci (Paris)

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Imaging biomarkers of outcome in the developing preterm brain

Cited by 353 publications

References 127 publications

The Instrumented Fetal Sheep as a Model of Cerebral White Matter Injury in the Premature Infant

The Instrumented Fetal Sheep as a Model of Cerebral White Matter Injury in the Premature Infant

High-field diffusion tensor imaging characterization of cerebral white matter injury in lipopolysaccharide-exposed fetal sheep

À propos du développement cérébral des prématurés

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