Imaging brain connectivity in children with diverse reading ability

Beaulieu, Christian; Plewes, Christopher; Paulson, Lori Anne; Roy, Dawne; Snook, Lindsay; Concha, Luis; Phillips, Linda M.

doi:10.1016/j.neuroimage.2004.12.053

Cited by 264 publications

(230 citation statements)

References 31 publications

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“…However, we did find functional differences in the left inferior frontal gyrus, the left superior parietal lobule and the left occipitotemporal cortex. Furthermore, most studies using diffusion tensor imaging (Beaulieu et al, 2005;Deutsch et al, 2005;Klingberg et al, 2000;Niogi and McCandliss, 2006) and voxelbased morphometry (VBM) (Eckert et al, 2005;Silani et al, 2005) have associated dyslexia with changes in anatomical connections of temporo-parietal regions. To date, only one VBM study found reduced gray matter density in the left inferior occipitotemporal cortex in adults and adolescents with dyslexia (Kronbichler et al, 2008).…”

Section: Accepted Manuscriptmentioning

confidence: 99%

The left occipitotemporal system in reading: Disruption of focal fMRI connectivity to left inferior frontal and inferior parietal language areas in children with dyslexia

et al. 2011

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The left occipitotemporal system in reading: Disruption of focal fMRI connectivity to left inferior frontal and inferior parietal language areas in children with dyslexia van der Mark, S; Klaver, P; Bucher, K; Maurer, U; Schulz, E; Brem, S; Martin, E; Brandeis, D van der Mark, S; Klaver, P; Bucher, K; Maurer, U; Schulz, E; Brem, S; Martin, E; Brandeis, D (2011). The left occipitotemporal system in reading: Disruption of focal fMRI connectivity to left inferior frontal and inferior parietal language areas in children with dyslexia. The left occipitotemporal system in reading: Disruption of focal fMRI connectivity to left inferior frontal and inferior parietal language areas in children with dyslexia Abstract Developmental dyslexia is a severe reading disorder, which is characterized by dysfluent reading and impaired automaticity of visual word processing. Adults with dyslexia show functional deficits in several brain regions including the so-called "Visual Word Form Area" (VWFA), which is implicated in visual word processing and located within the larger left occipitotemporal VWF-System. The present study examines functional connections of the left occipitotemporal VWF-System with other major language areas in children with dyslexia. Functional connectivity MRI was used to assess connectivity of the VWF-System in 18 children with dyslexia and 24 age matched controls (age 9.7-12.5 years) using five neighbouring left occipitotemporal regions of interest (ROIs) during a continuous reading task requiring phonological and orthographic processing. First, the results revealed a focal origin of connectivity from the VWF-System, in that mainly the VWFA was functionally connected with typical left frontal and parietal language areas in control children. Adjacent posterior and anterior VWF-System ROIs did not show such connectivity, confirming the special role that the VWFA plays in word processing. Second, we detected a significant disruption of functional connectivity between the VWFA and left inferior frontal and left inferior parietal language areas in the children with dyslexia. The current findings add to our understanding of dyslexia by showing that functional disconnection of the left occipitotemporal system is limited to the small VWFA region crucial for automatic visual word processing, and emerges early during reading acquisition in children with dyslexia, along with deficits in orthographic and phonological processing of visual word forms. ÔØ Å ÒÙ× Ö ÔØThe left occipitotemporal system in reading: Disruption of focal fMRI connectivity to left inferior frontal and inferior parietal language areas in children with dyslexia This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the cont...

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Section: Accepted Manuscriptmentioning

confidence: 99%

The left occipitotemporal system in reading: Disruption of focal fMRI connectivity to left inferior frontal and inferior parietal language areas in children with dyslexia

et al. 2011

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“…Standard processing steps included slice-scan-time correction, realignment, normalization of the images using a 7th-degree spline interpolation method to match to the Montreal Neurological Institute template (MNI) as in other studies with children (Beaulieu et al, 2005;Bolger et al, 2008a;Kucian et al, 2006;Schulz et al, 2008;van der Mark et al, 2009), resampling to isometric voxels (3 mm 3 ) and smoothing with a 9mm full-width at half maximum isotropic Gaussian kernel. Although transforming children's brains to an adult standard atlas may introduce some shape and variability differences in specific locations, these differences do not substantially affect functional imaging data, especially in children older than 7 years of age (Burgund et al, 2002;Kang et al, 2003).…”

Section: Fmri Recordings Processing and Analysismentioning

confidence: 99%

Early emergence of deviant frontal fMRI activity for phonological processes in poor beginning readers

et al. 2010

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“…There is a relationship between the white matter structure of children's brains and reading performance. White matter comprises the bulk of the deep parts of the brain and is responsible for information transmission (Beaulieu and Phillips 2005 (Murchison et al 2004). …”

Section: Chaptermentioning

confidence: 99%

Efficient Learning for the Poor: Insights from the Frontier of Cognitive Neuroscience

Abadzi¹

2006

PsycEXTRA Dataset

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Imaging brain connectivity in children with diverse reading ability

Cited by 264 publications

References 31 publications

The left occipitotemporal system in reading: Disruption of focal fMRI connectivity to left inferior frontal and inferior parietal language areas in children with dyslexia

The left occipitotemporal system in reading: Disruption of focal fMRI connectivity to left inferior frontal and inferior parietal language areas in children with dyslexia

Early emergence of deviant frontal fMRI activity for phonological processes in poor beginning readers

Efficient Learning for the Poor: Insights from the Frontier of Cognitive Neuroscience

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