Imaging comparison of tubular and colloid pancreatic adenocarcinoma arising from intraductal papillary mucinous neoplasm on multidetector CT

Escalon, Joanna G.; Gerst, Scott R.; Porembka, Matthew R.; Allen, Peter J.; Gian, Richard Kinh

doi:10.1016/j.clinimag.2016.08.011

Cited by 7 publications

(2 citation statements)

References 21 publications

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“…Various types of comprehensive therapies are available and target therapies have been regarded as the most important component of treatments for patients with IPMN; however, the 5-year survival rate of patients with IPMN is still poor ( 5 , 6 ). Notably, although a previous report has indicated that the imaging comparison of tubular and colloid pancreatic adenocarcinoma arising from IPMN on multidetector may be detected by computed tomography (CT) ( 7 ), diagnostic accuracy and sensitivity has not been improved for patients with early-stage IPMN. Furthermore, IPMN is associated with a spectrum of histologic and imaging findings, which have demonstrated the malignant transformation from adenoma to invasive carcinoma ( 8 ).…”

Section: Introductionmentioning

confidence: 99%

Application of a novel targeting nanoparticle contrast agent combined with magnetic resonance imaging in the diagnosis of intraductal papillary mucinous neoplasm

et al. 2018

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Intraductal papillary mucinous neoplasm (IPMN) is a severe disease with macroscopic visible mucin secretion that primarily occurs in biliary tracts or pancreatic ducts. In comparison with standard diagnostic imaging, probing the molecular abnormalities associated with the initial stages of diseases rather than imaging the end effects markedly improves the accuracy of diagnosis. In the present study, magnetic resonance imaging (MRI) in combination with the contrast agent PEGylated magnetoliposome consisting of gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) and target molecules of IPMN were investigated in the diagnosis of patients with suspected IPMN. The present investigation indicated that the novel targeting nanoparticle contrast agent targeted platelet-derived growth factor receptor-β and RET, and maintained a high affinity with tumor markers located on the IPMN surface. The novel targeting nanoparticle contrast agent combined with MRI exhibited increased sensitivity in diagnosing early-stage patients with IPMN. Furthermore, image quality was improved following the use of the novel targeting nanoparticle contrast agent combined with MRI compared with standard MRI. The targeting nanoparticle contrast agent retained sufficient affinity and was present for an adequate amount of time to observe the tumor mass in papillae using MRI. Notably, the targeting nanoparticle contrast agent was metabolized at 12 h post-injection. In conclusion, these outcomes indicate that the novel targeting nanoparticle contrast agent combined with MRI improved image quality and sensitivity compared with standard MRI, which suggests that this approach may be promising for clinical detection in patients with suspected IPMN.

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Section: Introductionmentioning

confidence: 99%

Application of a novel targeting nanoparticle contrast agent combined with magnetic resonance imaging in the diagnosis of intraductal papillary mucinous neoplasm

et al. 2018

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“…At present, only small cases studies of CC of the pancreas on MRI and contrast-enhanced CT have been reported ( 6 – 12 ). However, due to the absence of the typical features on MRI and contrast-enhanced CT, it is always hard to distinguish CC from other pancreatic tumors, such as IPMN and MCN.…”

Section: Introductionmentioning

confidence: 99%

Assessment of pancreatic colloid carcinoma using 18F‑FDG PET/CT compared with MRI and enhanced CT

et al. 2018

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Pancreatic colloid carcinoma (CC) is a rare sub-type of pancreatic adenocarcinoma which has an improved prognosis compared with pancreatic ductal carcinoma. Consequently, the early detection of CC by imaging may be of great significance in guiding patient management and therapeutic decisions. The present study aimed to analyze 18F-FDG PET/CT findings of CC in comparison to MRI and CT. PET/CT findings in 5 patients with CC were retrospectively reviewed based on visual interpretation and semi-quantitative index of SUVmax and TNR. Four patients received dual-time-point PET/CT scans. Additionally, one patient underwent contrast-enhanced CT scan, one MRI, and three received both. A total of five lesions were detected in five patients. Visually, two cases presented with mild FDG uptake, two with moderate and one with high. The mean of SUVmax and TNR was 5.1±2.2 and 2.8±0.7, respectively. Compared with CCs with low SUVmax, CCs with high SUVmax were more aggressive. No distant metastases were observed in five cases. Among four patients with dual-time-point PET/CT imaging, SUVmax increased in three cases and decreased in one case. The mean early and delayed SUVmax were 4.2±1.1 and 4.7±1.9, respectively (P>0.05). Radiological findings mainly included septated cystic components, internal sponge-like contrast-enhancement, calcification and ‘salt-and-pepper sign’ on MRI T2-weighted imaging. Thus, PET/CT provided additional information on metabolic tumor activity as well as locoregional and distant staging, which are important prognostic markers and may improve further patient management. However, PET/CT did not show any findings in addition to MRI and contrast-enhanced CT that were unique to CC and allowed a clear differentiation from other pancreatic malignancies.

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Systematic review of challenging issues in pathology of intraductal papillary mucinous neoplasms

Wood,

Adsay,

Basturk

et al. 2023

Pancreatology

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Imaging comparison of tubular and colloid pancreatic adenocarcinoma arising from intraductal papillary mucinous neoplasm on multidetector CT

Cited by 7 publications

References 21 publications

Application of a novel targeting nanoparticle contrast agent combined with magnetic resonance imaging in the diagnosis of intraductal papillary mucinous neoplasm

Application of a novel targeting nanoparticle contrast agent combined with magnetic resonance imaging in the diagnosis of intraductal papillary mucinous neoplasm

Assessment of pancreatic colloid carcinoma using 18F‑FDG PET/CT compared with MRI and enhanced CT

Systematic review of challenging issues in pathology of intraductal papillary mucinous neoplasms

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