Imaging features of glomus tumors

Glazebrook, Katrina N.; Laundre, Bryan J.; Schiefer, Terry K.; Inwards, Carrie Y.

doi:10.1007/s00256-010-1067-1

Cited by 65 publications

(109 citation statements)

References 14 publications

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“…21 Marked vascularity of Doppler ultrasonographic evaluation has been described. 22 MR imaging has been described as the most sensitive modality, especially for smaller tumors. 22 A characteristic well-circumscribed T2 hyperintense lesion is most often found.…”

Section: Discussionmentioning

confidence: 99%

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Clinical and Histopathological Diagnosis of Glomus Tumor

et al. 2015

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Background Glomus tumors are relatively uncommon subcentimeteric benign perivascular neoplasms usually located on the fingers. With their blue-red color and common subungual location, they are commonly confused for vascular or melanocytic lesions. To date there is no comprehensive review of an institutional experience with glomus tumors. Methods A 14-year retrospective review of all cases within University of California, Los Angeles, with either a clinical or pathological diagnosis of glomus tumor was performed. Data obtained included demographic information, tumor description, pathological diagnoses, immunohistochemical studies, radiographic and treatment information, and clinical course. Rates of concordance between clinical and pathological diagnoses and an evaluation of overlap with other entities were assessed. Results Clinical diagnosis of glomus tumor showed concordance with a histopathological diagnosis (45.4% of cases). The most common alternate clinical diagnoses included lipoma, cyst, or angioma. A pathological diagnosis of glomus tumor was most common in the fourth to seventh decades of life. The most common presentation was a subcentimeter lesion on the digit. Deep-seated tumors had a strikingly increased risk for malignancy (33%). Radiological studies were not relied on frequently (18.2% of cases). Immunohistochemical analysis showed diffuse αSMA and MSA expression in nearly all cases (99% and 95%, respectively), with focal to diffuse CD34 immunostaining in 32% of cases. Discussion Our study illustrates trends in the clinical versus pathologic diagnoses of glomus tumor, common competing diagnoses, a difference in demographics than is commonly reported (older age groups most commonly affected), and important differences in the use adjunctive diagnostic tools including radiology and immunohistochemistry.

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Section: Discussionmentioning

confidence: 99%

“…22 MR imaging has been described as the most sensitive modality, especially for smaller tumors. 22 A characteristic well-circumscribed T2 hyperintense lesion is most often found. 22,23 Notably, the majority of published articles are in the form of case reports or small, retrospective case series.…”

Section: Discussionmentioning

confidence: 99%

Clinical and Histopathological Diagnosis of Glomus Tumor

et al. 2015

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“…Glomus tumors show increased signal intensity on T2 weighted images during high resolution MRI, thus being useful in identifying the tumor preoperatively and in evaluating its pathological process even in extradigital glomus tumors. However, it should be kept in mind that the possibility of a false negative result may arise when the tumor size is 2-3 mm [7]. …”

Section: Discussionmentioning

confidence: 99%

Concomitant Glomus Tumor with CRPS in the Hand

et al. 2013

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Glomus tumors are benign tumors that account for 1% to 5% of all soft tissue tumors of the hand and are characterized by a triad of sensitivity to cold, localized tenderness and severe paroxysmal pain. Paroxysmal pain is a symptom common not only in glomus tumors but also in CRPS, and the hand is one of the commonly affected sites in patients with both glomus tumors and CRPS. Therefore, it is not easy to clinically diagnose glomus tumors superimposed on already affected region of CRPS patients. We report a case of glomus tumor concomitantly originating with CRPS at the hand.

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“…2,3 A recent study analyzed the imaging features of GTs in 25 cases: they are identified as wellcircumscribed, hypoechoic, highly vascularized masses on echography and color-Doppler evaluation and present with high T2 signal intensity and uniform enhancement after gadolinium administration at MRI. 4 Malignant features are extremely rare. [5][6][7][8][9][10][11][12][13][14][15][16][17] Malignant GTs, also known as glomangiosarcomas, seem to represent less than 1% of cases of GTs and occur mostly in nonacral sites.…”

Section: Discussionmentioning

confidence: 98%

Malignant Glomus Tumor of the Leg Developed in the Context of a Superficial Typical Glomus Tumor

et al. 2012

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A 41-year-old man presented with a 2-cm painful subcutaneous nodule in his right leg, which had been present for more than 10 years and was recently enlarging. Histologically, the tumor was composed of sheets and nests of cells with variable cytomorphology, including typical round/ovoid glomus cells with clear cytoplasm and well-defined borders, small cells, and spindle cells. Numerous medium to large vessels were present. Nodules with moderate to high cellularity, nuclear atypia, and frequent mitotic figures (42 per 50 high-power fields) were noted. Immunohistochemistry showed cytoplasmic and membranous expression of smooth-muscle actin, vimentin, and membranous expression of type IV collagen. Whereas superficiality, dimensions, and long-term follow-up may suggest classification as a symplastic or uncertain potential glomus tumor (GT), histological features and immunoprofile are indicative of malignant nodules developed in a typical GT. The follow-up has been negative for recurrence/metastases. A search of the literature revealed 17 cases of malignant GTs between 1995 and 2010, all fatal, of which 10 had skin as the primary site.

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Imaging features of glomus tumors

Cited by 65 publications

References 14 publications

Clinical and Histopathological Diagnosis of Glomus Tumor

Clinical and Histopathological Diagnosis of Glomus Tumor

Concomitant Glomus Tumor with CRPS in the Hand

Malignant Glomus Tumor of the Leg Developed in the Context of a Superficial Typical Glomus Tumor

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