Imaging features of thalassaemia

Gosein, Maria; Maharaj, Paramanand; Balkaransingh, Pauline; Banfield, Renee; Greene, Camille; Latchman, Sunil; Sinanan, Alexander

doi:10.1259/bjr.20180658

Cited by 9 publications

(4 citation statements)

References 9 publications

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“…Patients with β-thalassemia intermedia and major can develop postcranial lesions, including subperiosteal marrow proliferation and new bone formation that covers the entire outer costal surface (rib-within-rib), small compression fractures in vertebrae (Adamopoulos and Petrocheilou, 2020), and Erlenmeyer flask deformities affecting particularly the humerus and femurs (Gosein et al, 2019;Adamopoulos and Petrocheilou, 2020). These alterations are not visible in sk.485 and are also scarcely identified in other possible paleopathological cases as can be seen in Table 1 and in the five infants (ages from 3 to 9 months) and an 8-year-old child reported by Tayles (1996) with unspecified genetic anemias, dated from the 2nd century CE, from the Khuk Phanin Di site (Thailand).…”

Section: Discussionmentioning

confidence: 99%

Possible thalassemia intermedia in a child (16th–18th century) from the westernmost part of Europe: potential association with malaria and past migrations

Monge Calleja,

Lourenço,

Macedo

et al. 2024

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This study describes a non-adult individual with bone features suggestive of β-thalassemia, a disease commonly found in malaria-endemic regions today and in the past. The skeleton of a 5.5-to 6.5-year-old child exhumed from a 16th-to 18th-century CE necropolis in Almeirim (Portugal) was examined macroscopically, with a scanning electron microscope, and by conventional radiology and computed tomography. This individual shows frontoparietal diploic hyperplasia with a slight hair-onend radiographic appearance and an exuberant serpiginous pattern. The orbital roofs have a plaque-like formation and facial bones display new bone proliferation and porosity. The teeth show caries, calculus deposition, anomalies on the four deciduous canine roots, and linear enamel hypoplasia on the first permanent right upper central incisor. The postcranial skeleton presents osteopenic trabecular appearances, cribra humeralis, and cribra femoralis, the latter associated with malaria. A second non-adult individual (2.5-3.5 years old) had similar lesions in the cranium, raising the question of whether they were siblings. The lesions are consistent with β-thalassemia intermedia, a homozygous or compound heterozygous hemoglobinopathy found in malaria-endemic regions, such as Almeirim, due to the protective advantage conferred by β-thalassemia carriers. Thalassemia presents a wide spectrum of lesions common in other hemolytic anemias, which makes the diagnosis a challenge. Hopefully, biomolecular techniques will assist the diagnosis in skeletonized individuals. To the authors' knowledge, this is the first possible case of thalassemia in the westernmost part of Europe, in a region currently with high prevalence of hemoglobinopathies, attributed to the past Islamic and sub-Saharan presence, and in an area historically affected by malaria.

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Section: Discussionmentioning

confidence: 99%

Possible thalassemia intermedia in a child (16th–18th century) from the westernmost part of Europe: potential association with malaria and past migrations

Monge Calleja,

Lourenço,

Macedo

et al. 2024

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“…Multisystem evaluations should be done frequently to ensure any systemic involvement of the disease or progression. Based on any clinical suspicion, imaging is necessary to be done as in gallbladder and biliary tract imaging, cardiac MRI, abdominal ultrasonography to assess and determine the carrier systemic status [16].…”

Section: Diagnosis and Subtypes Of Thalassemiamentioning

confidence: 99%

An Overview on Thalassemia Diagnosis and Management Approach, Literature Review

Manea¹,

Khan²,

Alsharyufi³

et al. 2021

Int j pharm res allied sci

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Thalassemia syndromes are the most common inherited monogenic diseases that kill and affect millions of people worldwide. As Thalassemic diseases became a healthcare system burden for many countries around the world Thalassemia management emerges as a lifetime treatment program that should regularly be monitored with preferable choice for management. In this review we aim to collect and summarize recent articles, studies, and clinical trials in diagnosing and managing thalassemia, and provide a summarized, yet comperhansive study. PubMed database was used for this review and data was collected from relevant journal articles, randomized controlled trials, and observational studies containing the term used in the mesh "Thalassemia" "Management" "Diagnosis" "Laboratory" "Treatment" within the title or abstract. The major pathophysiological change that occurs in thalassemia is the imbalance of the globin chain production. Thalassemia management emerges as a lifetime treatment program that includes intensive medical and surgical care with ongoing monthly clinical visits.

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“…Marrow hyperplasia represents the serious osseous alteration which are further characterized with medullary expansion, generalized cortical thinning, spreading of bone caliber, coarsened trabecular pattern, cancellous bone resorption as well as osteopenia, which may result in pathological fractures. (9,10) A study on the radiographic features of jaws and teeth in patients with thalassemia using orthopantomography resulted large bone marrow spaces widely found in the posterior mandibular region. (11) On top of that, the study also found most cases revealed canal mandibular loss, imbalance crown body length of mandibular incisor, thinning of lamina dura and inferior cortex.…”

Section: Introductionmentioning

confidence: 99%

Mandibular changes in a patient suspected with Thalassemia trait: A case report by radiograph finding

Annisa Putri,

Ernita Sari,

Yolanda Kartika Asmarani

2024

World J. Adv. Res. Rev.

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Thalassemia is an inherited hemolytic anemia characterized by abnormal synthesis the hemoglobin globin component. A forty-year-old woman presented to a private dentist complaining of a left-sided facial pain and headache that occurred out of the blue. Panoramic radiograph showed severe caries on several teeth, generalized reduction in the alveolar crest, thin lamina dura and changes in trabecular pattern of mandible and the inferior alveolar canal on each side was partially absent. Unmanaged anemia caused ineffective erythropoiesis resulting extensive bone marrow with sparse coarse trabecular. As the mean hemoglobin falls, enhanced osteoclastic bone resorption thus thinning lamina dura, reducing alveolar crest and lacking radiopaque line of inferior alveolar canal. Panoramic is widely used in dentistry, this case report presents a case of patient discovered thalassemia through radiological findings.

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Imaging features of thalassaemia

Cited by 9 publications

References 9 publications

Possible thalassemia intermedia in a child (16th–18th century) from the westernmost part of Europe: potential association with malaria and past migrations

Possible thalassemia intermedia in a child (16th–18th century) from the westernmost part of Europe: potential association with malaria and past migrations

An Overview on Thalassemia Diagnosis and Management Approach, Literature Review

Mandibular changes in a patient suspected with Thalassemia trait: A case report by radiograph finding

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