Imaging methods in primary Sjögren’s syndrome as potential tools of disease diagnostics and monitoring

Świecka, Marta; Maślińska, Maria; Paluch, Łukasz; Zakrzewski, Jakub; Kwiatkowska, Brygida

doi:10.5114/reum.2019.91273

Cited by 18 publications

(16 citation statements)

References 43 publications

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“…A possible explanation for the leakage of contrast medium in pSS patients is dysfunction of tight junctions between striated ductal cells, due to the presence of proinflammatory cytokines [ 30 ]. In addition to sialectasis, sparsity of the ductal branching pattern can be found during sialography [ 3 , 31 , 32 ]. This could be due to obstruction of the ductal system, as a result of lymphocytic infiltration and proliferation of the ductal epithelium.…”

Section: Radiology Techniquesmentioning

confidence: 99%

“…It is an invasive technique with risk of complications and radiation exposure. Furthermore, there are multiple contraindications like acute infection, acute inflammation, and contrast allergy [ 3 , 31 ].…”

Section: Radiology Techniquesmentioning

confidence: 99%

“…The multiple hypointense and hyperintense areas cause a so-called salt and pepper appearance [ 34 ]. In the advanced stages of pSS, cystic changes can be found with MRI, which are thought to arise from destruction of the salivary gland parenchyma and the presence of fibrosis and fatty infiltration [ 3 , 31 , 36 ]. Although fat fractions in salivary glands seem to increase with higher age and body mass index [ 37 ] and can account for 60% of the histological section of the parotid gland in healthy individuals [ 38 ], imaging studies found that premature fat deposition found on MRI images is associated with SS [ 39 , 40 ].…”

Section: Radiology Techniquesmentioning

confidence: 99%

“…However, due to the low specificity and the inability to differentiate uptake failure from secretory failure, scintigraphy was omitted from the ACR-EULAR classification criteria [ 14 , 88 ]. Various studies stated that scintigraphic examination should focus on the degree of salivary gland dysfunction in pSS, instead of the differentiation between pSS and non-SS [ 31 , 89 ].…”

Section: Nuclear Medicine Techniquesmentioning

confidence: 99%

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Imaging in Primary Sjögren’s Syndrome

Ginkel

Glaudemans

Vegt

et al. 2020

JCM

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Primary Sjögren’s syndrome (pSS) is a systemic autoimmune disease characterized by dysfunction and lymphocytic infiltration of the salivary and lacrimal glands. Besides the characteristic sicca complaints, pSS patients can present a spectrum of signs and symptoms, which challenges the diagnostic process. Various imaging techniques can be used to assist in the diagnostic work-up and follow-up of pSS patients. Developments in imaging techniques provide new opportunities and perspectives. In this descriptive review, we discuss imaging techniques that are used in pSS with a focus on the salivary glands. The emphasis is on the contribution of these techniques to the diagnosis of pSS, their potential in assessing disease activity and disease progression in pSS, and their contribution to diagnosing and staging of pSS-associated lymphomas. Imaging findings of the salivary glands will be linked to histopathological changes in the salivary glands of pSS patients.

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Section: Radiology Techniquesmentioning

confidence: 99%

Section: Radiology Techniquesmentioning

confidence: 99%

Section: Radiology Techniquesmentioning

confidence: 99%

Section: Nuclear Medicine Techniquesmentioning

confidence: 99%

See 2 more Smart Citations

Imaging in Primary Sjögren’s Syndrome

Ginkel

Glaudemans

Vegt

et al. 2020

JCM

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“…The liver elastography assessment determining the degree of organ fibrosis has already entered into a daily practice, while its use in case of other parenchymal organs, such as kidney, breasts, thyroid, salivary glands and lymph nodes is currently emerging [17,18]. Obviously, it is important to validate the method and correctly interpret the results for each type of tissue.…”

Section: Introductionmentioning

confidence: 99%

Applicability of shear wave elastography for the evaluation of skin strain in systemic sclerosis

Sobolewski

Maślińska

Zakrzewski³

et al. 2020

Rheumatol Int

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The assessment of skin fibrosis is vital for the diagnosis and monitoring of treatment in the systemic sclerosis (SSc)-a severe autoimmune disease. The elastography is a technique of skin fibrosis assessment through the evaluation of skin strain. We compared the efficacy of the shear wave elastography (SWE) and commonly used modified Rodnan skin score (RSS) in skin fibrosis assessment in SSc. The study included 40 SSc patients and 28 healthy individuals, with the exclusion of individuals with other skin/autoimmune diseases. Skin thickness using RSS and skin strain using SWE were assessed in the same 20 body localizations. Subjects' informed consent and the bioethics committee approval were obtained. Elastographic skin strain correlated positively with both partial and overall RSS values, with strong positive correlation (r ≥ 0.75) for hands and fingers localizations in particular. In SSc patients with normal RSS values, the elastographic strain was significantly higher than in healthy controls. Elastographic strain of fingers' skin evaluated in SWE is highly accurate for distinguishing SSc patients (sensitivity 0.897-0.923, specificity 0.929-0.964, positive predictive value 0.946-0.973, negative predictive value 0.867-0.900). ESW results are substantially more reproducible than those of RSS examination (intraclass correlation coefficients: 0.987 vs. 0.941). The shear wave elastography is more reproducible and has higher sensitivity than RSS in the evaluation of skin condition in SSc, especially in case of changes non-detectable on physical evaluation, indicating it might become a useful tool in SSc diagnosis.

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Correlations of MR Sialographic Gradings with the Clinical Measures of Sjögren's Syndrome

et al. 2022

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Objectives Sjögren syndrome (SS) features salivary gland architectural changes such as ductal deformities and fat deposition secondary to inflammatory cell infiltrates; however, the anatomical and pathophysiological correlations of SS remain to be determined. This study aimed to determine the correlations of imaging findings based on the magnetic resonance (MR) sialography with the clinical and laboratory aspects of SS patients. Methods We evaluated the MR sialographic findings of two pairs of parotid glands (PGs) and submandibular glands (SMGs) from 41 SS patients. The distinct MR sialographic features were then compared with the clinical symptoms, biological (anti‐SSA/Ro antibody positivity), histological (labial gland focus score), and functional (salivary flow and scintigraphy) data. Results Ductal deformities such as sialectasis in the PG ducts were exclusively observed in SS, and fat replacement in SMGs was more distinct in patients with SS than in non‐SS sicca patients. Of the 82 PGs and SMGs from 41 SS patients, the grade of sialectasis in PGs on MR sialographic images and fat stage in SMGs showed strong correlations with anti‐SSA/Ro‐positivity. PG sialectasis was found more frequently in patients with dry mouth and decreased salivary gland function. A significant correlation was found between fat deposition in PGs and SMGs and decreased salivary gland function. Conclusion These results suggest that MR sialography is a reliable, adjunctive anatomical and functional study to assess SS. Detail aspects of sialectasis and fat accumulation encountered on MR sialography in SS patients can help physicians assume the disease status in SS. Level of Evidence 3 Laryngoscope, 133:307–316, 2023

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Imaging methods in primary Sjögren’s syndrome as potential tools of disease diagnostics and monitoring

Cited by 18 publications

References 43 publications

Imaging in Primary Sjögren’s Syndrome

Imaging in Primary Sjögren’s Syndrome

Applicability of shear wave elastography for the evaluation of skin strain in systemic sclerosis

Correlations of MR Sialographic Gradings with the Clinical Measures of Sjögren's Syndrome

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