Imaging myocardial fiber orientation using polarization sensitive optical coherence tomography

Fan, Chuanmao; Yao, Gang

doi:10.1364/boe.4.000460

Cited by 81 publications

(106 citation statements)

References 15 publications

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“…The OPT method was implemented in a 0.85 μm wavelength spectral-domain Jones matrix PSOCT system which has been described in detail previously [12,13]. Briefly, the system measures pixel-wise Jones matrix of the sample by using incident light with alternating rightand left-circular polarizations.…”

Section: Opt Systemmentioning

confidence: 99%

“…For each incident polarization, the horizontally and vertically polarized components of the interference signals were detected using a custom spectrometer equipped with a 1024-pixel line scan camera running at 50k A-lines/sec. An iterative Jones calculus based algorithm was applied to extract the depth-resolved optic axis for mapping the fiber orientation [13]. The fiber orientation measured is between [-90°, 90°] and represents the projected orientations within the plane perpendicular to the incident light [8,14], which is analog to the "helix" angle measured in DTI [2,7].…”

Section: Opt Systemmentioning

confidence: 99%

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Heart structural remodeling in a mouse model of Duchenne cardiomyopathy revealed using optical polarization tractography [Invited]

Wang

Zhang

Duan

et al. 2017

Biomed. Opt. Express

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Abstract:We investigated the heart structural remodeling in the mdx4cv mouse model of Duchenne cardiomyopathy using optical polarization tractography. Whole heart tractography was obtained in freshly dissected hearts from six mdx4cv mice. Six hearts from C57BL/6J mice were also imaged as the normal control. The mdx4cv hearts were significantly larger than the control hearts and had significantly higher between-subject variations in myofiber organization. While both strains showed classic cross-helical fiber organization in the left ventricle, the rate of the myocardial fiber orientation change across the heart wall was significantly altered in the right ventricle of the mdx4cv heart.

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Section: Opt Systemmentioning

confidence: 99%

Section: Opt Systemmentioning

confidence: 99%

Heart structural remodeling in a mouse model of Duchenne cardiomyopathy revealed using optical polarization tractography [Invited]

Wang

Zhang

Duan

et al. 2017

Biomed. Opt. Express

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show abstract

“…The OPT method uses Jones calculus based algorithms to calculate the "local" optic axis from cumulative measurements in Jones-matrix PSOCT as described in detail previously [13,14]. Briefly, the "round-trip" pixel-wise Jones matrix of the entire imaging volume J RT (φ n ,2ρ n ) was constructed, where the cumulative complex retardance ρ n and axis φ n from the n th depth layer can be calculated.…”

Section: Opt Algorithm and Imaging Systemmentioning

confidence: 99%

“…Such an effect changed the orientation of the "evaluation" plane and distorted the original 3D rectangular image grid (i, j, k) and was corrected before image registration [17]. The sample surface boundary was first identified using an intensity-based thresholding method as in our previous studies [13,14]. A 5 × 5 pixel median filter was applied to remove noisy pixels on the resulting 2D surface.…”

Section: Image Registrationmentioning

confidence: 99%

“…However, fiber detection based on intensity contrast can be affected by non-fiber related intensity variations and only works in tissues with large fibers. We recently developed optical polarization tractography (OPT) for imaging tissue fiber orientation [11][12][13]. OPT is based on Jones matrix polarization-sensitive OCT (PSOCT) and uses the depth-resolved "local" optic axis to construct the 3D fiber tractographic images of the sample.…”

Section: Introductionmentioning

confidence: 99%

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Mapping 3D fiber orientation in tissue using dual-angle optical polarization tractography

Wang¹,

Ravanfar²,

Zhang³

et al. 2016

Biomed. Opt. Express

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Optical polarization tractography (OPT) has recently been applied to map fiber organization in the heart, skeletal muscle, and arterial vessel wall with high resolution. The fiber orientation measured in OPT represents the 2D projected fiber angle in a plane that is perpendicular to the incident light. We report here a dual-angle extension of the OPT technology to measure the actual 3D fiber orientation in tissue. This method was first verified by imaging the murine extensor digitorum muscle placed at various known orientations in space. The accuracy of the method was further studied by analyzing the 3D fiber orientation of the mouse tibialis anterior muscle. Finally we showed that dual-angle OPT successfully revealed the unique 3D "arcade" fiber structure in the bovine articular cartilage.

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Polarization-Sensitive OCT Imaging of Scleral Abnormalities in Eyes With High Myopia and Dome-Shaped Macula

Ohno-Matsui,

Igarashi-Yokoi,

Azuma

et al. 2024

JAMA Ophthalmol

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ImportanceThe relevance of visualizing scleral fiber orientation may offer insights into the pathogenesis of pathologic myopia, including dome-shaped maculopathy (DSM).ObjectiveTo investigate the orientation and density of scleral collagen fibers in highly myopic eyes with and without DSM by polarization-sensitive optical coherence tomography (PS-OCT).Design, Setting, and ParticipantsThis case series included patients with highly myopic eyes (defined as a refractive error ≥6 diopters or an axial length ≥26.5 mm) with and without a DSM examined at a single site in May and June 2019. Analysis was performed from September 2019 to October 2023.ExposuresThe PS-OCT was used to study the birefringence and optic axis of the scleral collagen fibers.Main Outcomes and MeasuresThe orientation and optic axis of scleral fibers in inner and outer layers of highly myopic eyes were assessed, and the results were compared between eyes with and without a DSM.ResultsA total of 72 patients (51 [70.8%] female; mean [SD] age, 61.5 [12.8] years) were included, and 89 highly myopic eyes were examined (mean [SD] axial length, 30.4 [1.7] mm); 52 (58.4%) did not have a DSM and 37 (41.6%) had a DSM (10 bidirectional [27.0%] and 27 horizontal [73.0%]). Among the 52 eyes without DSM, the 13 eyes with simple high myopia had primarily inner sclera visible, displaying radially oriented fibers in optic axis images. In contrast, the entire thickness of the sclera was visible in 39 eyes with pathologic myopia. In these eyes, the optic axis images showed vertically oriented fibers within the outer sclera. Eyes presenting with both horizontal and bidirectional DSMs had clusters of fibers with low birefringence at the site of the DSM. In the optic axis images, horizontally or obliquely oriented scleral fibers were aggregated in the inner layer at the DSM. The vertical fibers located posterior to the inner fiber aggregation were not thickened and appeared thin compared with the surrounding areas.Conclusions and RelevanceThis study using PS-OCT revealed inner scleral fiber aggregation without outer scleral thickening at the site of the DSM in highly myopic eyes. Given the common occurrence of scleral pathologies, such as DSM, and staphylomas in eyes with pathologic myopia, recognizing these fiber patterns could be important. These insights may be relevant to developing targeted therapies to address scleral abnormalities early and, thus, mitigate potential damage to the overlying neural tissue.

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Imaging myocardial fiber orientation using polarization sensitive optical coherence tomography

Cited by 81 publications

References 15 publications

Heart structural remodeling in a mouse model of Duchenne cardiomyopathy revealed using optical polarization tractography [Invited]

Heart structural remodeling in a mouse model of Duchenne cardiomyopathy revealed using optical polarization tractography [Invited]

Mapping 3D fiber orientation in tissue using dual-angle optical polarization tractography

Polarization-Sensitive OCT Imaging of Scleral Abnormalities in Eyes With High Myopia and Dome-Shaped Macula

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