Imaging Observation of Nano-Artificial Bone in the Repair of the Defect in Osteonecrosis of the Femoral Head

Abstract

To observe the effect of nano-artificial bone and bone marrow mesenchymal stem cells (BMSCs) in the treatment of femoral head osteonecrosis. The bilateral femoral head internal bone defect model was established and divided into three groups. Group A was used to make the defect without filling any material as the control, group B was only filled with nano-artificial bone, and group C was filled with composite materials of nano-artificial bone and bone marrow mesenchymal stem cells. The femoral head was examined using radiography and high-resolution focused 48-slice computed tomography (CT) at 12 weeks after implantation. A significant difference was found between groups B and C in the aspect of repairing the defect in osteogenesis of the femoral head as compared with the control group. Nano-collagen-based bone has strong osteogenic and osteogenic effects and is a good graft material for repairing bone defects of the femoral head. The use of bone marrow mesenchymal stem cells can promote the repair of bone defects, which is of great value in the treatment of osteonecrosis of the femoral head.

The Antibacterial Effect, Biocompatibility, and Osteogenesis of Vancomycin-Nanodiamond Composite Scaffold for Infected Bone Defects

“… 53 , 54 However, rejection of allogeneic bone affects fracture healing. 55 An increasing number of scholars are currently focusing on the preparation of artificial bone repair materials 56 , 57 and local drug release systems. 58 , 59 Various composite bone scaffolds have achieved varying degrees of results in animal experiments.…”

Research status and progress of bone marrow mesenchymal stem cells for osteonecrosis of femoral head

“…At present, the treatment of ONFH is mainly based on the stage of ARCO and the patient's own condition. However, due to the poor efficacy of hip preservation therapy in patients with advanced ONFH, it is of great importance to identify and treat ONFH as soon as possible [9] . In recent years, with the continuous development of stem cell research, relevant studies have shown that BMSCs have certain clinical efficacy in the treatment of ONFH, and it has gradually become a hot topic in orthopedics research field.…”