Imaging of childhood angiomatoid fibrous histiocytoma with pathological correlation

Yıkılmaz, Ali; Ngan, Bo–Yee; Navarro, Oscar M.

doi:10.1007/s00247-015-3404-y

Cited by 15 publications

(16 citation statements)

References 23 publications

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“…The onset age of the current case was similar to that of previously described cases [10]. Subcutaneous AFH in the iliac region is extremely rare.…”

Section: Discussionsupporting

confidence: 85%

“…Some groups have reported MRI features of AFH, including cystic areas, pseudocapsules, edema of surrounding mass, enhancement, and fluid–fluid levels [10–12], which were observed in the current case. Although the MRI features of AFH described in the literature may aid diagnosis [6, 13], none of them are considered to be significant [10]. The characteristic histological features of AFH have been well described [2].…”

Section: Discussionsupporting

confidence: 51%

“…In the current case, it is possible that the origin of the tumor was the external iliac lymph node. The presence of systemic symptoms, such as weight loss, malaise, fever, and anemia [10–12], which occur in some patients, can aid diagnosis. However, in the current case, the patient experienced no systemic symptoms.…”

Section: Discussionmentioning

confidence: 99%

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Treatment of angiomatoid fibrous histiocytoma after unplanned excision: a case report

et al. 2018

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BackgroundAngiomatoid fibrous histiocytoma (AFH) is a relatively uncommon soft tissue tumor of intermediate biologic potential. It occurs in subcutaneous regions of the extremities or the trunk, usually presenting in children or young adults. This is the first reported case of subcutaneous AFH that developed in the iliac region and was treated with an unplanned resection.Case presentationAn 11-year-old girl noticed a small subcutaneous nodule in the iliac region. As the nodule was asymptomatic, it was observed naturally for a year, after which her parents consulted her doctor due to gradual growth of the nodule. The tumor was resected marginally without biopsy by a non-specialized surgeon. Based on the histology of the resected specimen, the tumor was suspected to be a sarcoma. The patient was referred to our hospital where we reinvestigated the histology of the tumor using immunohistochemistry. After confirming diagnosis of the tumor as an AFH, we undertook additional extensive resection in the iliac region where the tumor had developed. There was no evidence of tumor residue in the resected specimen. It has been 3 years since the operation, and there has been no evidence of recurrence.ConclusionWe treated a case of AFH after unplanned resection. If subcutaneous tumors in the iliac region are detected, a diagnosis of AFH should be considered and a simple resection avoided.

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“…The onset age of the current case was similar to that of previously described cases [10]. Subcutaneous AFH in the iliac region is extremely rare.…”

Section: Discussionsupporting

confidence: 85%

Section: Discussionsupporting

confidence: 51%

See 1 more Smart Citation

Treatment of angiomatoid fibrous histiocytoma after unplanned excision: a case report

et al. 2018

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“…Some groups have reported the MRI features of AFH, including cystic areas, pseudocapsules, peritumoral edema, enhancement, and fluid–fluid level [7–13]. On the basis of these findings, we evaluated the imaging characteristics of each case (Table 2, Figs.…”

Section: Resultsmentioning

confidence: 99%

“…The pattern of gadolinium enhancement is a variegated internal and nodular peripheral appearance. In addition, some groups reported that AFH shows cystic areas, pseudocapsules, hemosiderin, and fluid–fluid levels on MRI [7–13]. Martinez et al reported the double rim sign and invasive pattern as novel MRI findings for AFH [15].…”

Section: Discussionmentioning

confidence: 99%

Angiomatoid fibrous histiocytoma: a series of seven cases including genetically confirmed aggressive cases and a literature review

Saitô

Kobayashi²,

Yoshida

et al. 2017

BMC Musculoskelet Disord

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BackgroundAngiomatoid fibrous histiocytoma (AFH) is a rare soft tissue tumor of intermediate biologic potential. Because of its rarity and nonspecific radiological and diverse pathological findings, AFH is often clinically misdiagnosed. However, few clinical reports have described this tumor. As reported herein, we analyzed the clinical and radiological features and clinical outcomes of AFH.MethodsWe retrospectively reviewed the medical records of seven cases histopathologically diagnosed as AFH. We examined clinical features, MRI findings, histopathological diagnoses, treatments, and outcomes.ResultsThese seven cases comprised five male and two female patients with ages ranging from 8 to 50 years old. The primary locations included upper extremities in 2, lower extremities in 4, and the inguinal region in one patient. Of the tumors, 4 occurred in subcutaneous tissues and 3 occurred in deep tissues. No cases were diagnosed as AFH from MRI and needle biopsy results. All cases were diagnosed histopathologically after excision. After treatment, 2 patients (29%) had tumor recurrence and metastasis, one of whom died from disease progression. These 2 aggressive cases involved both EWSR1 and CREB1 gene rearrangements as determined by FISH. The other patients were alive and well without recurrence or metastasis.ConclusionAFH is a rare tumor that is difficult to diagnose. Therefore, it tends to be misdiagnosed and to be treated inadequately by referring physicians. Surgeons must therefore be mindful of the presence of AFH, learn about appropriate treatment necessary for this tumor, and conduct careful follow-up because AFH can engender poor outcomes.

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Clinical and sonographic features of pediatric soft-tissue vascular anomalies part 2: vascular malformations

Johnson

Navarro

2017

Pediatr Radiol

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Vascular malformations are a heterogeneous group of entities, many of which present in the pediatric age group. Sonography plays a major role in the management of children with these vascular anomalies by providing information that helps in diagnosing them, in assessing lesion extent and complications, and in monitoring response to therapy. The interpretation of sonographic findings requires correlation with clinical findings, some of which can be easily obtained at the time of scanning. This has to be combined with the use of appropriate nomenclature and the most updated classification in order to categorize these patients into the appropriate management pathway. Some vascular malformations are part of combined vascular anomalies or are associated with syndromes that include other disorders, frequently limb overgrowth, and these are now being reclassified based on their underlying genetic mutation. Sonography has limitations in the evaluation of some vascular malformations and in these cases MR imaging might be considered the imaging modality of choice, particularly for lesions that are large, that involve multiple compartments or are associated with other soft-tissue and bone abnormalities. In this article, which is part 2 of a two-part series, the authors review the most relevant clinical and sonographic features of arteriovenous, capillary, venous and lymphatic malformations as well as vascular malformations that are part of more complex conditions or associated with syndromes, including Parkes-Weber syndrome, phosphatase and tensin homologue (PTEN) hamartoma tumor syndromes, Klippel-Trénaunay syndrome, CLOVES (congenital lipomatous overgrowth, vascular malformations, epidermal nevi and skeletal anomalies) syndrome, fibro-adipose vascular anomaly and Proteus syndrome.

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Imaging of childhood angiomatoid fibrous histiocytoma with pathological correlation

Cited by 15 publications

References 23 publications

Treatment of angiomatoid fibrous histiocytoma after unplanned excision: a case report

Treatment of angiomatoid fibrous histiocytoma after unplanned excision: a case report

Angiomatoid fibrous histiocytoma: a series of seven cases including genetically confirmed aggressive cases and a literature review

Clinical and sonographic features of pediatric soft-tissue vascular anomalies part 2: vascular malformations

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