2004
DOI: 10.1097/01.rlu.0000134981.56669.1e
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Imaging of Infected Total Arthroplasty With Tc-99m-labeled Antigranulocyte Antibody Fab′ Fragments

Abstract: The high negative predictive accuracy in the whole group suggests that the scan can be used to exclude infection in most cases. Negative results with a high clinical suspicion merits further investigation. A positive result will require further correlative imaging, especially for total knee replacement.

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Cited by 20 publications
(4 citation statements)
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“…Of the 23 studies included for meta-analysis, six used bone scintigraphy [12, 20, 27, 34, 40, 50], four used bone leukocyte scintigraphy [20, 34, 41, 50], six used leukocyte scintigraphy [18, 28, 34, 37, 38, 50], seven used leukocyte bone marrow scintigraphy [2, 7, 9, 16, 17, 21, 34], five used antigranulocyte scintigraphy [14, 15, 40, 44, 52], and five used fluorodeoxyglucose (FDG)-PET [2, 21, 23, 50, 56]. Altogether, a total of 1027 diagnostic images, 404 (39%) with and 623 (61%) without periprosthetic knee infection, were evaluated in 1502 patients with 763 knee prostheses, of which 288 (38%) were infected (Table 1).…”
Section: Methodsmentioning
confidence: 99%
“…Of the 23 studies included for meta-analysis, six used bone scintigraphy [12, 20, 27, 34, 40, 50], four used bone leukocyte scintigraphy [20, 34, 41, 50], six used leukocyte scintigraphy [18, 28, 34, 37, 38, 50], seven used leukocyte bone marrow scintigraphy [2, 7, 9, 16, 17, 21, 34], five used antigranulocyte scintigraphy [14, 15, 40, 44, 52], and five used fluorodeoxyglucose (FDG)-PET [2, 21, 23, 50, 56]. Altogether, a total of 1027 diagnostic images, 404 (39%) with and 623 (61%) without periprosthetic knee infection, were evaluated in 1502 patients with 763 knee prostheses, of which 288 (38%) were infected (Table 1).…”
Section: Methodsmentioning
confidence: 99%
“…Since extended statistical evaluations have been performed previously, 2,4,6,7 the present study focused instead on the imaging quality of 99m Tcbesilesomab and 99m Tc-sulesomab.…”
Section: Discussionmentioning
confidence: 99%
“…54 Nuclear medicine bone scan has been shown to be highly accurate with sensitivities and specificities ranging from 91 to 100% and 47 to 100%, respectively. [55][56][57][58][59][60] Despite the impressive performance of bone scan in these studies, a recent meta-analysis showed significant heterogeneity between studies, with significant variation in the studies' definition of PJI. 61 Furthermore, there are numerous nuclear medicine techniques that have been evaluated, and no one technique can be recommended.…”
Section: Diagnostic Imagingmentioning
confidence: 99%