Imaging of joint response to exercise with MRI and PET

Comparing the Effect of Mechanical Loading on Deep and Superficial Cartilage Using Quantitative UTE MRI

“…3,4 However, the variation of T2* depends on the duration and type of mechanical loading and the investigated zones. 4,5 The possible mechanisms could include redistribution of free water in cartilage, collagen fiber re-orientation and changes of water protons binding to collagen. 6,7 Furthermore, alerted T2 and T2* values have also been observed in long-term abnormal mechanical environments due to cartilage matrix degradation.…”

“…In this context, MRI is the most promising noninvasive technique for the study of cartilage loading. Specifically, MRI can assess not only cartilage deformation, but also microstructural and compositional changes in response to loading using quantitative sequences 3,4 . Decreases of T2 and T1ρ have been found under static and dynamic loading, except for marathon running 3,4 .…”

“…Specifically, MRI can assess not only cartilage deformation, but also microstructural and compositional changes in response to loading using quantitative sequences 3,4 . Decreases of T2 and T1ρ have been found under static and dynamic loading, except for marathon running 3,4 . However, the variation of T2* depends on the duration and type of mechanical loading and the investigated zones 4,5 .…”

“…Decreases of T2 and T1ρ have been found under static and dynamic loading, except for marathon running 3,4 . However, the variation of T2* depends on the duration and type of mechanical loading and the investigated zones 4,5 . The possible mechanisms could include redistribution of free water in cartilage, collagen fiber re‐orientation and changes of water protons binding to collagen 6,7 .…”