Imaging of Joints and Bones in Autoinflammation

Ziegeler, Katharina; Eshed, Iris; Diekhoff, Torsten; Hermann, Kay-Geert A.

doi:10.3390/jcm9124074

Cited by 9 publications

(6 citation statements)

References 68 publications

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“…In adults, the anterior chest wall is the most commonly affected part (approximately 65%–90%), followed by the spine (approximately 30%) and the sacroiliac joint (13%–52%), and occasionally the mandible or the long bones of the limbs (3). However, in children, the metaphysis of the long bones is most commonly involved, and lesions of the spine and clavicle are relatively rare (38). Severe pain and other uncomfortable symptoms can significantly affect a patient's night sleep quality and increase anxiety.…”

Section: Discussionmentioning

confidence: 99%

Clinical and imaging features of six Han patients with SAPHO syndrome

Ruan

Wang

et al. 2022

Acta Radiol

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Background Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is a rare autoimmune disease characterized by skin or osteoarticular damage. SAPHO syndrome is often misdiagnosed or missed diagnosis due to lack of overall understanding of the disease by clinicians. Purpose To analyze the clinical symptoms and imaging features of six Han patients with SAPHO syndrome in order to provide reference for doctors to diagnose SAPHO syndrome. Material and Methods This study retrospectively analyzed the clinical data of six Han patients with SAPHO syndrome. Results All six Han patients with SAPHO syndrome had severe acne or pustulosis of the hands and feet, and all of them had osteoarticular damage, including five cases involving the sternoclavicular joint. Some patients showed a specific and typical “bull's head” sign on 99mTc-labeled methylene diphosphonate bone imaging. Among the six patients recruited, there was one thoracic vertebra, one cervical vertebra, one sacroiliac joint, and one peripheral joint involvement. Two patients had limited activity due to severe osteoarticular damage. Conclusion Due to the atypical clinical symptoms of SAPHO syndrome, most patients will experience a tortuous and long diagnostic process, while a correct understanding and timely intervention of SAPHO syndrome are essential to improve the prognosis of patients.

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Section: Discussionmentioning

confidence: 99%

Clinical and imaging features of six Han patients with SAPHO syndrome

Ruan

Wang

et al. 2022

Acta Radiol

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“…Synovitis of large and medium joints is also frequently encountered in microcrystalline and autoimmune rheumatological disorders and is not discriminating. In contrast, axial involvement of the cervical spine; peri-capitate carpal destruction/fusion with metacarpophalangeal joints sparing [15,16]; trapezoid-metacarpal fusion; and, in young patients, distal interphanlangeal joints destruction [17] are much more specific, because only a few diseases are associated with this subtype of lesions [18]. Joints MRI patterns are not specific and show, as in rheumatoid arthritis, synovitis.…”

Section: Radiologicalmentioning

confidence: 99%

Strategy and Challenges of Paraclinical Examinations in Adult-Onset Still’s Disease

Poursac

Odriozola

Truchetet

2022

JCM

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Adult-onset Still’s disease is a complex autoinflammatory disease with a multifactorial etiology. Its presentation is less stereotypical than that of a monogenic autoinflammatory disease and is actually relatively common with few specific signs. To avoid under- or over-prescription of complementary examinations, it is useful to advance in a structured manner, taking into consideration the actual added value of each supplemental examination. In this review, we detail the different complementary tests used in adult Still’s disease. We consider them from three different angles: positive diagnostic approach, the differential diagnosis, and the screening for complications of the disease. After discussing the various tests at our disposal, we look at the classical diagnostic strategy in order to propose a structured algorithm that can be used in clinical practice. We conclude with the prospects of new complementary examinations, which could in the future modify the management of patients.

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“…X-rays might be unremarkable in the early stage of the disease and this does not exclude the diagnosis. Lytic, poorly define or well defined lesions can be seen early with progressive sclerosis or cortical thickening of the bone in the reparative phase ( 4 , 10 , 55 – 59 ). We and others have suggested fluorodeoxyglucose (FDG), positron emission tomography (PET)-computed tomography (CT)-scan, and bone scintigraphy as diagnostic tools ( 6 ).…”

Section: Imagingmentioning

confidence: 99%

Chronic recurrent multifocal osteomyelitis. A narrative and pictorial review

et al. 2022

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Chronic recurrent and multifocal osteomyelitis (CRMO) is a nonsporadic autoinflammatory disorder. Currently, it is diagnosed based on clinical, radiologic, pathological, and longitudinal data. Numerous aspects should be highlighted due to increased knowledge in imaging and immunology. We emphasize the use of whole-body MRI, which is a non-invasive diagnostic strategy. A literature review was carried out on longitudinal studies. Commonly, the mean age at diagnosis is 11 years, ranging between 3 and 17. The most common sites are the long bone metaphysis, particularly femoral and tibial metaphysis. In addition, the pelvis, spine, clavicle, and mandible may be involved. In long bones, the radiologic appearance can show typical structure, mixed lytic and sclerotic, sclerotic or lytic. It is frequently metaphyseal or juxta-physeal, with hyperostosis or periosteal thickening. The involvement of the vertebral skeleton is often multifocal. Therefore, whole-body MRI is essential in identifying subclinical lesions. CRMO is a polymorphic disorder in which whole-body MRI is beneficial to demonstrate subclinical edema. Vertebral collapse requires long-term monitoring.

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Imaging of Joints and Bones in Autoinflammation

Cited by 9 publications

References 68 publications

Clinical and imaging features of six Han patients with SAPHO syndrome

Clinical and imaging features of six Han patients with SAPHO syndrome

Strategy and Challenges of Paraclinical Examinations in Adult-Onset Still’s Disease

Chronic recurrent multifocal osteomyelitis. A narrative and pictorial review

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