Imaging of neuroblastoma: an overview

Bousvaros, Athos; Kirks, Donald R.; Grossman, Herman

doi:10.1007/bf02386629

Cited by 112 publications

(76 citation statements)

References 67 publications

(104 reference statements)

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“…This tumor shows as a heterogeneously echogenic mass in the suprarenal area with anechoic areas on US; a large heterogeous solid mass with calcifications (about 80 90%) (9) and low attenuation areas of necrosis or hemorrhage are seen on CT (10). It frequently shows uncommon cystic change in neonates, but it tends to be solid even in the older child (11). This gastric teratoma gave us several diagnostic clues that were different from neuroblastoma.…”

Section: Discussionmentioning

confidence: 93%

Exogastric Mature Teratoma in an Infant: A Case Report

Seo

Hwang

Kim

et al. 2006

J Korean Radiol Soc

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Section: Discussionmentioning

confidence: 93%

Exogastric Mature Teratoma in an Infant: A Case Report

Seo

Hwang

Kim

et al. 2006

J Korean Radiol Soc

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“…17,26) Over 70% of neuroblastoma patients have disseminated disease at the time of diagnosis. 1,5) Common sites of distant metastases are the bone marrow, bony cortex, liver, lymph nodes, and subcutaneous tissue. 1,5,21) Intraorbital metastasis is also a common finding.…”

Section: Introductionmentioning

confidence: 99%

“…1,5) Common sites of distant metastases are the bone marrow, bony cortex, liver, lymph nodes, and subcutaneous tissue. 1,5,21) Intraorbital metastasis is also a common finding. 1,14,20) However, central nervous system (CNS) metastasis rarely occurs, in only 1-16% of cases.…”

Section: Introductionmentioning

confidence: 99%

Unexpected Intraparenchymal Hematoma Caused by Brain Metastasis in a Patient With Neuroblastoma -Case Report-

Okura

Yatomi

Saito

et al. 2011

Neurol. Med. Chir.(Tokyo)

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A 2-year-old girl who had previously been treated for stage IV intra-abdominal neuroblastoma presented with headache and vomiting. Computed tomography (CT) showed hematoma in the right temporal lobe. Two months previously, she had suffered a generalized seizure but brain CT was unremarkable. The hematoma was removed completely without evidence of vascular anomaly or tumor. Four weeks after surgery, magnetic resonance imaging with gadolinium showed a developing mass lesion in the hematoma bed. A second operation for tumor removal confirmed the rare diagnosis of intraparenchymal metastasis. Metastatic neuroblastoma to the central nervous system (CNS) occasionally can cause massive hemorrhage. Therefore, early detection of CNS metastasis can be important. The related factors in this patient with abdominal neuroblastoma included elevated serum lactate dehydrogenase, N-myc gene amplification, and coexisting orbital metastasis, which all occurred within 22 months from initial diagnosis. The median interval from diagnosis of the primary tumor to diagnosis of CNS metastasis in neuroblastoma is 12-22 months, which indicates relatively late metastasis presentation. The initial presentation of this late metastasis is hemorrhage that can have sudden detrimental consequences, so a patient with neuroblastoma must be followed up carefully, particularly if elevated serum lactate dehydrogenase, orbital metastasis, N-myc gene amplification, or clinical symptoms are present, even if brain CT is unremarkable. The understanding that intraparenchymal hematoma can occur prior to detectable CNS metastasis may be important for early detection of this life-threatening condition.

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“…4 Neuroblastomas can be clinically silent until they invade or compress adjacent structures, metastasize, or produce paraneoplastic syndromes. 60 One previous case report of a patient with neuroblastoma metastasis to the sphenoid sinus described symptoms of vision loss, frontal bossing, prominent vessels on the forehead, periorbital ecchymoses, and bilateral mild proptosis. 61 On imaging, metastatic neuroblastoma may have calcifications and cystic components and frequently appears as an area of mottled bone destruction when bone is involved.…”

mentioning

confidence: 99%

“…60 It is the most common solid tumor in children, with a median age at diagnosis of 19 months. 38 Head and neck lesions are typically metastases.…”

mentioning

confidence: 99%

Sphenoid Masses in Children: Radiologic Differential Diagnosis with Pathologic Correlation

Lui

Dasari²,

Young³

2010

AJNR Am J Neuroradiol

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SUMMARY:Childhood central skull base masses are rare, often difficult to diagnose, and have overlapping imaging findings. In this review, we provide an overview of the epidemiology, clinical findings, and management of pediatric sphenoid bone and sphenoid sinus masses with an emphasis on imaging findings that may help to differentiate lesions. Radiologic-pathologic correlation is provided. Finally, an imaging-based algorithm is presented as a guide to help radiologists narrow their differential diagnoses. Some of the entities discussed are virtually unique to the pediatric population; others occur rarely in this age group but should be considered in the appropriate clinical setting. Entities included in the discussion are grouped into 2 categories: those that cause nonaggressive osseous remodeling and those that are more commonly associated with aggressive bone changes. Mucocele, aneurysmal bone cyst, giant cell lesions, meningioma, and fibrous dysplasia tend to remodel bone, while entities such as chordoma, craniopharyngioma, rhabdomyosarcoma, sinonasal carcinoma, and neuroblastoma may cause more aggressive local bone changes.ABBREVIATIONS: FLAIR ϭ fluid-attenuated inversion recovery: HE ϭ hematoxylin-eosin; NF 1 ϭ neurofibromatosis type 1; NF 2 ϭ neurofibromatosis type 2; T1WI ϭ T1 weighted imaging; T2WI ϭ T2 weighted imaging

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Imaging of neuroblastoma: an overview

Cited by 112 publications

References 67 publications

Exogastric Mature Teratoma in an Infant: A Case Report

Exogastric Mature Teratoma in an Infant: A Case Report

Unexpected Intraparenchymal Hematoma Caused by Brain Metastasis in a Patient With Neuroblastoma -Case Report-

Sphenoid Masses in Children: Radiologic Differential Diagnosis with Pathologic Correlation

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