This review article briefly describes the pathology, clinical features, prognosis, and treatment of neuroblastoma. The emphasis is on applications of newer diagnostic modalities (sonography, nuclear scintigraphy, computed tomography) for imaging and staging. The potential role of magnetic resonance imaging and spectroscopy is discussed.

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No patient was stated to be other than white, but only a few reports specified the race of the individual. Frequency.-There is no doubt but that the cases described in the literature represent only a fraction of the total number of those recognized as disciform degeneration at the macula. Kahler and O'Brien state that 12 cases were seen in one year in the ophthalmologic clinic of the State University of Iowa. Age.-The majority of cases occurred in the fifth and sixth decades of life. The youngest patient was thirty-nine years of age (Neame), and the oldest was eighty-three (Kahler and O'Brien). The average age for the entire group was sixtyeight. Age, therefore, was a definite factor. Sex.-Of the 84 patients, 47 were male and 34 female, and in 3 instances the sex was not stated.