No patient was stated to be other than white, but only a few reports specified the race of the individual. Frequency.-There is no doubt but that the cases described in the literature represent only a fraction of the total number of those recognized as disciform degeneration at the macula. Kahler and O'Brien state that 12 cases were seen in one year in the ophthalmologic clinic of the State University of Iowa. Age.-The majority of cases occurred in the fifth and sixth decades of life. The youngest patient was thirty-nine years of age (Neame), and the oldest was eighty-three (Kahler and O'Brien). The average age for the entire group was sixtyeight. Age, therefore, was a definite factor. Sex.-Of the 84 patients, 47 were male and 34 female, and in 3 instances the sex was not stated.

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FOR the privilege of making'this report I am indebted to the late Dr. Grady E. Clay. It deals with the.microscopic examination of one eye removed after death from a patient with angioid streaks in both eyes. The eye was removed under the direction of Dr. Clay and sent by him to Dr. Algernon Reese-for sectioning. A complete set of celloidin sections was prepared and stained under Dr, Reese's supervision and then sent to me at the request of Dr. Clay. The hospital at which the patient died was the Grady Memorial Hospital of Atlanta, Georgia, and to the'authorities of this'institution I am indebted for complete copies of the hospital records including the autopsy report on this patient. The clinical record was signed by Guh H. Adams, M.D. The autopsy was performed by Abner Golden, M.D., and the report signed by Walter H. Sheldon, M.D., pathologist.-For the purposes of this paper the following summary of these hospital records will suffice: The patient, a 50-year-old coloured female was admitted to the Grady Memorial Hospital, Atlanta, Ga., Jan. 28, 1944. She was known to have had syphilis which was inadequately treated. However, the Kahn test was negative at the final admission to the hospital although in 1935 the Wassermann test was 4 plus. She was known to have had hypertension since 1935. In 1939 the blood pressure was recorded as 200/110 ind at this time she began to experience intermittent oedema of the ankles. lThere were not marked symptoms, however, until three 531 copyright.

closing: I wish to thank those who discussed the paper, especially Dr. Friedenwald, for bringing out so clearly how it is that in some cases we may have edema of the retina and in other tissues cystic formation. The optic nerve itself becomes edematous, the nerve fibers are separated, but no actual spaces are formed, but the adjacent retina may break up into holes. The optic nerve is the stronger tissue and the retina is the weaker and more delicate, so that under the same influence the former would show edema while the latter might be torn to pieces.