Imaging of Sjögren Syndrome and Immunoglobulin G4-Related Disease of the Salivary Glands

Fujita, Akifumi

doi:10.1016/j.nic.2018.01.003

Cited by 12 publications

(12 citation statements)

References 55 publications

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“…24,25 Although the salivary ducts were adequately visible in all patients in this study, ductal abnormalities beyond the MRSIAL resolution (0.6-0.8 mm) may have accounted for the only false-negative case in this series. Apart from the pepper and salt or spotted aspect of the parotid glands, 11,20,26 due to advances in highresolution MRSIAL, it became recently possible to identify SS imaging features initially described only on conventional sialography. These features (small cysts, duct stenosis/ectasia, and the classic "leafless fruit-laden tree" aspect), require very high imaging resolution.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Clinical Characteristics and Magnetic Resonance Imaging of Salivary Glands With Magnetic Resonance Sialography in Sjögren's Syndrome

et al. 2020

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Objectives/Hypothesis To compare the results of magnetic resonance imaging with magnetic resonance sialography (MRSIAL) and the clinical and laboratory characteristics in a well‐characterized cohort of patients with primary or secondary Sjögren's syndrome (SS) meeting the American–European Consensus Group criteria. Study Design: Retrospective, observational, monocentric study. Methods Thirty‐six patients (81% female, mean age = 48 ± 35 years) with primary or secondary SS who underwent MRSIAL were included in the study. Results MRSIAL revealed characteristic radiological signs in the parotid, sublingual, and submandibular salivary glands in 35/36 patients (97%). Patients presenting with anti‐Sjögren's syndrome–related antigen A (SSA) autoantibodies showed more often fatty infiltration, a “pepper‐and‐salt” appearance, ductal stenosis, and/or ductal dilation of the parotid gland (88%, 88%, and 72% respectively) than patients negative for anti‐SSA (12%, 4%, and 28% respectively). MRSIAL demonstrated signs characteristic of SS in all 11 patients with negative minor salivary gland biopsy. For 15 patients undergoing ultrasound examination only, 11 (73%) had SS findings, but all 15 had SS findings on MRSIAL. Two cases of parotid lymphoma were detected by MRSIAL (6%). Conclusions MRSIAL is a reliable technique to detect glandular anomalies in patients with SS, and seems to provide a valuable aid in the diagnosis of SS. Level of Evidence 4 Laryngoscope, 131:E83–E89, 2021

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Section: Discussionmentioning

confidence: 99%

Comparison of Clinical Characteristics and Magnetic Resonance Imaging of Salivary Glands With Magnetic Resonance Sialography in Sjögren's Syndrome

et al. 2020

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“…MR imaging has been used more and more for assessing the neoplastic and diffuse diseases of salivary gland. 15 Conventional structural MR imaging can provide 15 and can also assess the morphological changes of the diffuse diseases of salivary gland, including Sjögren's Syndrome, 16 sialadenitis 17 and radiation-related injury. 18 Besides that, multiple functional MR techniques, including various advanced diffusion-weighted imaging model and dynamic contrast-enhanced MR imaging, can supply additional information about cell density or vascular permeability in salivary gland disease.…”

Section: Discussionmentioning

confidence: 99%

Effect of laterality, gender, age and body mass index on the fat fraction of salivary glands in healthy volunteers: assessed using iterative decomposition of water and fat with echo asymmetry and least-squares estimation method

Wang

et al. 2019

Dentomaxillofacial Radiology

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Objectives: To evaluate the effect of laterality, gender, age and body mass index (BMI) on fat fraction (FF) measurements of both parotid glands (PGs) and submandibular glands (SMGs) by using: Iterative decomposition of water and fat with echo asymmetry and least-squares estimation method (IDEAL-IQ). Methods: A total of 87 healthy participants were enrolled in our study. IDEAL-IQ image was scanned using a 3.0 T scanner. Paired t test was performed to compare the difference on FF of both PGs and SMGs between left and right side. The FF of two glands between male and female healthy participants were compared using an unpaired t-test. The correlation between the FF of two glands and participant age or BMI were analyzed by Pearson's correlation. Results: Excellent inter-and intrareader agreements were obtained during the measurements of FF by IDEAL-IQ method (ICC, 0.952-0.981). FF values correlated positively with the age and BMI in both left and right PGs and SMGs (p < 0.05). No significant difference was found on FF between left and right PGs and SMGs (p > 0.05). There was also no difference on FF between male and female healthy participants (p > 0.05). conclusions: FFs of PGs and SMGs were age-and BMI-dependent, but not laterality-and gender-dependent. The effect of age and BMI need to be considered in further studies using Ideal-IQ technology to evaluate FFs of salivary gland diseases.

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“…However, we did not investigate the specific type of DPD, such as Sjögren’s syndrome or other autoimmune parotitis. In clinical practice, Sjögren’s syndrome is the most important type of DPD, because it is the main cause of xerostomia and increases the risk of B-cell lymphoma [1, 6, 7]. Therefore, further US studies investigating the specific DPD are required.…”

Section: Discussionmentioning

confidence: 99%

“…Primary Sjögren’s syndrome is a chronic progressive autoimmune disease of unknown etiology [1]. Sjögren’s syndrome is characterized by lymphocytic infiltration and the obstruction of exocrine glandular tissue, particularly in the lacrimal and salivary glands, thus resulting in xerostomia [1, 6, 7]. Patients with Sjögren’s syndromes should be annually monitored, because they have a 16- to 40-fold increased risk of developing B-cell lymphoma [8, 9].…”

Section: Introductionmentioning

confidence: 99%

Ultrasound detection of incidental diffuse parotid disease: A single-center study

et al. 2019

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In this study, we compared ultrasound (US) features between normal parotid parenchyma (NPP) and incidental diffuse parotid disease (DPD). From January 2008 to December 2017, 180 patients underwent neck US before parotid surgery at our hospital. From these, 82 were excluded because of the lack of histopathological data concerning the parotid parenchyma or inadequate US images. A single radiologist blinded to the clinicoserological data and histopathological results, retrospectively investigated all US features and categorizations for the parotid glands using a picture archiving and communication system. Retrospective histopathological analysis of the parotid parenchyma was performed by a single pathologist. On the basis of the histopathological analyses, the 98 patients were divided into NPP (n = 70) and DPD (n = 28) groups. Among US features, parenchymal echogenicity and echotexture showed statistically significant differences between the two groups ( p < 0.0001), whereas the gland size, margin, and vascularity showed no significant differences ( p > 0.05). The US-based categorization significantly differentiated between NPP and DPD ( p < 0.0001), and receiver operating characteristic curve analysis revealed that US categorization based on ≥2 abnormal US features showed the best diagnostic performance for detecting DPD. Thus, US can aid in differentiating DPD from NPP.

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Imaging of Sjögren Syndrome and Immunoglobulin G4-Related Disease of the Salivary Glands

Cited by 12 publications

References 55 publications

Comparison of Clinical Characteristics and Magnetic Resonance Imaging of Salivary Glands With Magnetic Resonance Sialography in Sjögren's Syndrome

Comparison of Clinical Characteristics and Magnetic Resonance Imaging of Salivary Glands With Magnetic Resonance Sialography in Sjögren's Syndrome

Effect of laterality, gender, age and body mass index on the fat fraction of salivary glands in healthy volunteers: assessed using iterative decomposition of water and fat with echo asymmetry and least-squares estimation method

Ultrasound detection of incidental diffuse parotid disease: A single-center study

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