Imaging peritoneal metastasis of gastric cancer with <sup>18</sup>F-fluorothymidine positron emission tomography/computed tomography: a proof-of-concept study

Honma, Yoshitaka; Terauchi, Takashi; Tateishi, Ukihide; Kano, Daisuke; Nagashima, Kengo; Shoji, Hirokazu; Iwasa, Satoru; Takashima, Atsuo; Kato, Ken; Hamaguchi, Tetsuya; Boku, Narikazu; Shimada, Yasuhiro; Yamada, Yasuhide

doi:10.1259/bjr.20180259

Cited by 18 publications

(10 citation statements)

References 27 publications

(37 reference statements)

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“…A systematic review by Riola-Parada et al [8] showed that PET/MRI was superior or similar to PET/CT for the diagnosis of more than 16 different neoplastic lesions. However, at present, the literature still supports PET/ CT as a main player in the diagnosis and staging of gastric cancer [9][10][11], and PET/MRI has rarely been reported as being used in the study of gastric tumors, which is partially because of the confounding effects from respiratory movements, gastrointestinal peristalsis and cardiac pulsation on MRI. Nevertheless, driven by the appealing merits of high soft tissue contract and no ionizing radiation, MRI is widely used in abdominal imaging.…”

Section: Introductionmentioning

confidence: 99%

Improving MR sequence of 18F-FDG PET/MR for diagnosing and staging gastric Cancer: a comparison study to 18F-FDG PET/CT

Zheng

Liu

et al. 2020

Cancer Imaging

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Purpose: Evaluate the feasibility of fluorine-18 (18 F) fluorodeoxyglucose (FDG) positron emission tomography (PET) and magnetic resonance (MR) imaging in patients with gastric cancer by optimizing the scan protocol and to compare the image quality to 18 F FDG PET and computed tomography (CT). Methods: The PET/CT and PET/MR imaging were sequentially performed in 30 patients with gastric cancer diagnosed by gastroscope using a single-injection-with-dual-imaging protocol. After intravenous injection of 18 F-FDG (mean, 249 MBq), PET/CT imaging including low-dose CT was performed (mean uptake time, 47 ± 6 min), and PET/MR imaging including a T1-weighted Dixon sequence for attenuation correction and two different T2-weighted sequences was subsequently acquired (88 ± 15 min after 18 F-FDG injection). Four series of images (CT from PET/CT, T1W, T2W Half-Fourier acquisition single-shot turbo spin-echo [T2W-HASTE] and T2W-BLADE from PET/MR) were visually evaluated using a 3-4 points scale for: (1) image artifacts, (2) lesion conspicuity and (3) image fusion quality. The characteristics of the primary lesions were assessed and compared between the PET/CT and PET/MR acquisitions. Results: The image quality and lesion conspicuity of the T2W-HASTE images were significantly improved compared to that of the T2W-BLADE images. A significantly higher number of artifacts were seen in the T2W-HASTE images compared with the T1W and CT images (p < 0. 05). No differences in the accuracy of image fusion between PET/MR and PET/CT (p > 0. 05); however, significant difference was seen in the lesion conspicuity measurements (p < 0.05) with T2W-HASTE being superior. For information about the primary lesion characteristics, the T2W-HASTE images provided the most successful identifications compared with those of the T1W and PET/CT (13vs7vs5) images. Conclusions: PET/MR with the T2W-HASTE was better at revealing the details of local stomach lesions compared with PET/CT imaging. Combining the PET/MR with the T2W-HASTE technique is a promising imaging method for diagnosing and staging gastric cancer.

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Section: Introductionmentioning

confidence: 99%

Improving MR sequence of 18F-FDG PET/MR for diagnosing and staging gastric Cancer: a comparison study to 18F-FDG PET/CT

Zheng

Liu

et al. 2020

Cancer Imaging

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“…In contrast to CT, PET has better performance, which means metabolic parameters play an important role in the model. The most commonly used metabolic parameter of PET/CT is SUVmax, which indicates the additional value of predicting metastasis and prognosis ( 44 , 45 ). In addition, CA125 is one of the clinically promising diagnostic markers in evaluating the efficacy of chemotherapy and predicting the prognosis of patients with peritoneal dissemination ( 46 ).…”

Section: Discussionmentioning

confidence: 99%

Development and Validation of a Radiomics Model Based on 18F-FDG PET of Primary Gastric Cancer for Predicting Peritoneal Metastasis

et al. 2021

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ObjectivesThe aim of this study was to develop a preoperative positron emission tomography (PET)-based radiomics model for predicting peritoneal metastasis (PM) of gastric cancer (GC).MethodsIn this study, a total of 355 patients (109PM+, 246PM-) who underwent preoperative fluorine-18-fludeoxyglucose (18F-FDG) PET images were retrospectively analyzed. According to a 7:3 ratio, patients were randomly divided into a training set and a validation set. Radiomics features and metabolic parameters data were extracted from PET images. The radiomics features were selected by logistic regression after using maximum relevance and minimum redundancy (mRMR) and the least shrinkage and selection operator (LASSO) method. The radiomics models were based on the rest of these features. The performance of the models was determined by their discrimination, calibration, and clinical usefulness in the training and validation sets.ResultsAfter dimensionality reduction, 12 radiomics feature parameters were obtained to construct radiomics signatures. According to the results of the multivariate logistic regression analysis, only carbohydrate antigen 125 (CA125), maximum standardized uptake value (SUVmax), and the radiomics signature showed statistically significant differences between patients (P<0.05). A radiomics model was developed based on the logistic analyses with an AUC of 0.86 in the training cohort and 0.87 in the validation cohort. The clinical prediction model based on CA125 and SUVmax was 0.76 in the training set and 0.69 in the validation set. The comprehensive model, which contained a rad-score and the clinical factor (CA125) as well as the metabolic parameter (SUVmax), showed promising performance with an AUC of 0.90 in the training cohort and 0.88 in the validation cohort, respectively. The calibration curve showed the actual rate of the nomogram-predicted probability of peritoneal metastasis. Decision curve analysis (DCA) also demonstrated the good clinical utility of the radiomics nomogram.ConclusionsThe comprehensive model based on the rad-score and other factors (SUVmax, CA125) can provide a novel tool for predicting peritoneal metastasis of gastric cancer patients preoperatively.

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“…A previous report identified that (F-18)FLT-PET/CT, despite low SUV, has a higher sensitivity than FDG-PET in GC, regardless of the histological type [65,66]. Honma et al [67], in a proof-of-concept study, explored the sensitivity of 18F-fluothymine (F-18)FLT PET/CT for detecting PM from GC previously identified by other imaging mo- A recent paper evaluated the value of FDG PET/MRI for assessing the extent of peritoneal metastases in 34 patients with ovarian and endometrial cancer [64]. They found a close correlation between PCI evaluation using PET/MRI, DW-MRI alone, and surgery.…”

Section: Novel Pet Radiotracersmentioning

confidence: 99%

“…A previous report identified that (F-18)FLT-PET/CT, despite low SUV, has a higher sensitivity than FDG-PET in GC, regardless of the histological type [65,66]. Honma et al [67], in a proof-of-concept study, explored the sensitivity of 18F-fluothymine (F-18)FLT PET/CT for detecting PM from GC previously identified by other imaging modalities. A total of 19 patients, including 15 patients with diffuse-type, were analysed.…”

Section: Novel Pet Radiotracersmentioning

confidence: 99%

Imaging of Gastric Carcinomatosis

Martínez

Dromain

Violi

2021

JCM

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Diagnosing the absence or presence of peritoneal carcinomatosis in patients with gastric cancer, including its extent and distribution, is an essential step in patients’ therapeutic management. Such diagnosis still remains a radiological challenge. In this article, we review the strengths and weaknesses of the different imaging techniques for the diagnosis of peritoneal carcinomatosis of gastric origin as well as the techniques’ imaging features. We also discuss the assessment of response to treatment and present recommendations for the follow-up of patients with complete surgical resection according to the presence of risk factors of recurrence, as well as discussing future directions for imaging improvement.

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Imaging peritoneal metastasis of gastric cancer with ¹⁸F-fluorothymidine positron emission tomography/computed tomography: a proof-of-concept study

Cited by 18 publications

References 27 publications

Improving MR sequence of 18F-FDG PET/MR for diagnosing and staging gastric Cancer: a comparison study to 18F-FDG PET/CT

Improving MR sequence of 18F-FDG PET/MR for diagnosing and staging gastric Cancer: a comparison study to 18F-FDG PET/CT

Development and Validation of a Radiomics Model Based on 18F-FDG PET of Primary Gastric Cancer for Predicting Peritoneal Metastasis

Imaging of Gastric Carcinomatosis

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Imaging peritoneal metastasis of gastric cancer with 18F-fluorothymidine positron emission tomography/computed tomography: a proof-of-concept study

Cited by 18 publications

References 27 publications

Improving MR sequence of 18F-FDG PET/MR for diagnosing and staging gastric Cancer: a comparison study to 18F-FDG PET/CT

Improving MR sequence of 18F-FDG PET/MR for diagnosing and staging gastric Cancer: a comparison study to 18F-FDG PET/CT

Development and Validation of a Radiomics Model Based on 18F-FDG PET of Primary Gastric Cancer for Predicting Peritoneal Metastasis

Imaging of Gastric Carcinomatosis

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Imaging peritoneal metastasis of gastric cancer with ¹⁸F-fluorothymidine positron emission tomography/computed tomography: a proof-of-concept study