Imaging Spectrum of Cystic Fibrosis

Shaheen, Nicholas H.; Targonska, Bogna; Kowal, Daniel J.

doi:10.1097/01.cdr.0000475549.20130.2f

Cited by 2 publications

(7 citation statements)

References 4 publications

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“…Head and neck manifestations are more common in adults than in children and include chronic sinusitis (in about 100% of cases), 12 nasal polyposis in up to 86% of cases 2 and chronic otitis media with middle ear effusion. Our patient also had chronic sinusitis manifested by chronic nasal stuffiness accompanied by her chronic cough.…”

Section: Discussion and Literature Reviewmentioning

confidence: 99%

“…As the disease progresses, the hemoptysis may intensify in frequency and volume and other complications, including pneumothorax, might follow. 2 , 15…”

Section: Pulmonary Manifestationsmentioning

confidence: 99%

“…The chronic CF features that can be detected on chest x-rays include: bronchiectasis, pulmonary hyperinflation, atelectasis, and features of pulmonary arterial hypertension marked by enlarged pulmonary arteries. 2 Different severity scores have been used to grade the severity of CF and structural changes on chest x-ray, with all scoring systems liable to inter- and intra-observer variability. The Brasfield ( Table 1 ) and Chrispin–Norman scoring systems show good inter- and intra-observer agreement and appreciable correlation with clinical data and spirometry findings.…”

Section: Pulmonary Manifestationsmentioning

confidence: 99%

“…The bronchiectasis typically undergoes progressive, severity-dependent intensification from cylindrical to varicoid to cystic. 2 Air trapping and mucus plugging, two consequences of bronchiectasis, are shown on the CT as mosaic attenuation and finger-in-glove patterns, respectively. Likewise, there were areas of mucus plugging in our case that might echo the severity of bronchiectasis ( Figure 1 ).…”

Section: Pulmonary Manifestationsmentioning

confidence: 99%

“…The manifestations of the disease are mainly due to excessive sodium chloride losses in sweat and different epithelial cells of the airways, GI and GU systems as a result of dysfunctional sodium channels in epithelial membranes of patients with the mutated CFTR gene. 2 CF patients, therefore, can present with a variety of clinical features, and imaging plays a significant role in the diagnosis and monitoring of CF.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Cystic Fibrosis in an Adolescent: A “Miranda Warning” Against Blaming TB—A Case-Based Scholarly Update

Adela,

Kebede,

Zewdneh

et al. 2024

AHMT

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Cystic fibrosis (CF) is a multisystem disorder that occurs as a result of autosomal recessive congenital transmission of CF transmembrane conductance regulator (CFTR) gene mutation on chromosome 7. Because it is considered a disease of the Caucasian pediatric population or due to lack of awareness, it is rarely considered in developing countries like ours. This case report presents the first case of cystic fibrosis ever reported in Ethiopia and possibly East Africa, that of a 17-year-old female diagnosed with the disease following a CT scan of her abdomen and chest. She was initially misdiagnosed and treated for tuberculosis (TB) as she was a chronic cougher. Perhaps due to epidemiological evidence, there is an obstinate tendency of blaming tuberculosis (TB) for almost every case of chronic cough with fibro-bronchiectatic lung parenchymal changes in Ethiopia. Once a diagnosis of TB is posted on such patients, their diagnosis remains in the circle of TB reinfection, relapse or resistance, followed by multiple phases of anti-mycobacterial drugs. This could lead to hazardous implications, including unnecessary prolonged anti-mycobacterial treatments, possibility of developing drug resistance, and mismanagement-related patient morbidity. This patient’s chest and abdominal CT findings, including bronchiectasis, hepatic steatosis, pancreatic lipomatosis, micro-gallbladder and proximal colonic wall thickening, led to the diagnosis of CF. This article, presenting the first documented case of CF in the region, is meant to be a helpful reminder for clinicians and radiologists to also consider presumably “rare” illnesses like CF rather than blaming TB for every chronic cough and highlights the importance of abdominal CT features in the diagnosis of CF.

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Section: Discussion and Literature Reviewmentioning

confidence: 99%

“…As the disease progresses, the hemoptysis may intensify in frequency and volume and other complications, including pneumothorax, might follow. 2 , 15…”

Section: Pulmonary Manifestationsmentioning

confidence: 99%

Section: Pulmonary Manifestationsmentioning

confidence: 99%

Section: Pulmonary Manifestationsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Cystic Fibrosis in an Adolescent: A “Miranda Warning” Against Blaming TB—A Case-Based Scholarly Update

Adela,

Kebede,

Zewdneh

et al. 2024

AHMT

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Meconium Peritonitis: A Case Study

Omansky¹

2018

Neonatal Network

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Meconium peritonitis is a sterile chemical peritonitis preceded by bowel perforation, resulting in meconium leakage and subsequent inflammatory cascade within the peritoneal cavity. The presentation can range from simple failure of the neonate to pass meconium to complications such as persistent pulmonary hypertension, lung hypoplasia, and systemic inflammatory syndrome. The purpose of this article is to review a case of meconium peritonitis while considering its etiology, diagnosis, management, and multidisciplinary team care.

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Imaging Spectrum of Cystic Fibrosis

Cited by 2 publications

References 4 publications

Cystic Fibrosis in an Adolescent: A “Miranda Warning” Against Blaming TB—A Case-Based Scholarly Update

Cystic Fibrosis in an Adolescent: A “Miranda Warning” Against Blaming TB—A Case-Based Scholarly Update

Meconium Peritonitis: A Case Study

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