Imaging Spectrum of TIPIC Syndrome

“TransIent perivascular inflammation of the carotid artery (TIPIC) syndrome” as a rare case of laterocervical pain: Multimodal diagnosis

“…The diagnosis of TIPIC syndrome requires imaging evidence of the exclusion of other vascular and non-vascular causes of neck pain ( Table 1 ) [10 , 11] . As compared with US, MRI is particularly useful in differentiating TIPIC syndrome from intramural hematoma or carotid dissection, that are the principal vascular differential diagnoses.…”

Transient perivascular inflammation of the carotid artery—A transient but potentially recurrent disease

“…9 Various studies addressed the issue of which techniques can best be used to diagnose and follow up the syndrome. 1,10,11 B-mode ultrasound and magnetic resonance imaging can easily visualize perivascular and intravascular changes, 9,12,13 whereas CT angiography and DSA may miss pathology as vascular stenosis or occlusion are not typical. 14 18F-FDG positron emission tomography can also be used to evaluate patients with TIPIC syndrome showing abnormal radiotracer uptake in the carotid artery wall and in cases when oncologic or systemic disease is suspected.…”

Transient perivascular inflammation of the carotid artery: Ultrasonography and magnetic resonance imaging findings

“…It may be accompanied by transient neurological symptoms such as dizziness and diplopia. [2][3][4][5] The etiology of the disease is still unclear and an inflammatory process involving the carotid wall, including the adventitia layer, is thought to be responsible. The nerve tract of carotid arteries is situated between the adventitia and media of the vessel wall.…”

“…Transient fatty plaques may be visualized in carotid arteries in the recovery phase. 2,4,6 Carotid artery dissection should be primarily considered in the differential diagnosis of TIPIC syndrome. In addition, other inflammatory arteriopathies, such as giant cell arteritis, Takayasu arteritis, postradiation carotid arteritis, fibromuscular dysplasia, carotid trunk paragangliomas, sialadenitis, thyroiditis, peritonsillar abscess/phlegmon, cervical spondylosis, and neck neoplasms should also be remembered in its differential diagnosis.…”

“…In addition, other inflammatory arteriopathies, such as giant cell arteritis, Takayasu arteritis, postradiation carotid arteritis, fibromuscular dysplasia, carotid trunk paragangliomas, sialadenitis, thyroiditis, peritonsillar abscess/phlegmon, cervical spondylosis, and neck neoplasms should also be remembered in its differential diagnosis. 2,4,[6][7][8][9] No treatment guideline currently exists for the treatment of TIPIC syndrome. Non-steroidal anti-inflammatory drugs are usually used to hasten its recovery.…”