2019
DOI: 10.1111/tpj.14169
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Imbalance of tyrosine by modulating TyrA arogenate dehydrogenases impacts growth and development of Arabidopsis thaliana

Abstract: L-Tyrosine is an essential aromatic amino acid required for the synthesis of proteins and a diverse array of plant natural products; however, little is known on how the levels of tyrosine are controlled in planta and linked to overall growth and development. Most plants synthesize tyrosine by TyrA arogenate dehydrogenases, which are strongly feedback-inhibited by tyrosine and encoded by TyrA1 and TyrA2 genes in Arabidopsis thaliana. While TyrA enzymes have been extensively characterized at biochemical levels, … Show more

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Cited by 29 publications
(23 citation statements)
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“…in Arabidopsis are largely derived from amino acids, results in metabolic imbalances that cannot support normal growth. This hypothesis is consistent with the idea that plants have the capacity to sense changes in the availability of amino acids and other primary metabolites, and to respond by adjusting the growth rate to a level that matches the availability of resources (Smith and Stitt, 2007;Guo et al, 2018a;de Oliveira et al, 2019). A challenge for future studies will be to determine how specific changes in metabolism during the growth-to-defense transition are mechanistically linked to growth.…”
Section: Discussionsupporting
confidence: 72%
“…in Arabidopsis are largely derived from amino acids, results in metabolic imbalances that cannot support normal growth. This hypothesis is consistent with the idea that plants have the capacity to sense changes in the availability of amino acids and other primary metabolites, and to respond by adjusting the growth rate to a level that matches the availability of resources (Smith and Stitt, 2007;Guo et al, 2018a;de Oliveira et al, 2019). A challenge for future studies will be to determine how specific changes in metabolism during the growth-to-defense transition are mechanistically linked to growth.…”
Section: Discussionsupporting
confidence: 72%
“…A similar phenomenon was observed in the Arabidopsis tyra2 mutant. Knocking out TyrA2 genes encoding an enzyme which synthesizes tyrosine in Arabidopsis led to the accumulation of slightly higher tyrosine levels instead of a lower level than in wild‐type plants, while the levels of leaf photosynthetic pigments, chlorophyll a , chlorophyll b and carotenoids were reduced in tyra2 (de Oliveira et al , ).…”
Section: Discussionmentioning
confidence: 99%
“…5a). Heterologous expression of the partially-deregulated TyrA a enzymes from beets indeed enhanced the production of tyrosine while still maintaining growth in Arabidopsis (213). Moreover, specific mutations underlying unique alterations in primary metabolic enzyme properties, identified through the aforementioned phylogeny-guided biochemical JBC REVIEWS: Harnessing plant primary metabolic diversity approach, can also be introduced to corresponding endogenous genes of host plants (Fig.…”
Section: Harnessing Primary Metabolic Diversity For Building and Optimentioning
confidence: 99%