iMeta: Integrated meta‐omics for biology and environments

Liu, Yong‐Xin; Chen, Tong; Li, Danyi; Fu, Jingyuan; Liu, Shuang‐Jiang

doi:10.1002/imt2.15

Cited by 16 publications

(12 citation statements)

References 34 publications

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“…Microbiome research has experienced major technical, practical, and conceptual progress in recent years ( Lynch et al, 2019 ; Liu et al, 2022 ). During the early days, the initial focus was to describe the composition and diversity of microbiomes and to identify correlations between microbes and host phenotypes.…”

Section: Global Trends and Advancements In Microbiome Research: From ...mentioning

confidence: 99%

Microbiome research outlook: past, present, and future

Gao

Li²,

Liu

2023

Protein &Amp; Cell

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With its critical role in human health and disease, the microbiome has transformed modern biology. Over the past few years, microbiome research has evolved rapidly, with microbiologists gradually shifting their focus from cataloging microorganisms in the human microbiome to understanding their functional roles and how they interact with the host. Here, we present the global trends in microbiome research and summarize the past and current work on microbiome published in Protein & Cell. In closing, we highlight some of the major advancements in microbiome research, including technical, practical, and conceptual advancements, that aim to enhance disease diagnosis, medicine development, and personalized interventions

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Section: Global Trends and Advancements In Microbiome Research: From ...mentioning

confidence: 99%

Microbiome research outlook: past, present, and future

Gao

Li²,

Liu

2023

Protein &Amp; Cell

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“…The structural composition of the gut microbiota is the result of strong selection and co-evolution between the host and its environment, and studies in a variety of mammals (e.g., humans, ruminants, rabbits, rhesus macaques, mice, etc.) have confirmed that the gut microbiota positively contributes to the adaptation of its hosts to high-altitude environments 2,[10][11][12][13][14] . Metabolites, such as short-chain fatty acids (SCFAs), bacteriocins, and bacterial proteins produced by gut microbiota, play important roles in host metabolic regulation, energy replenishment, and immune regulation [15][16][17][18][19] .…”

Section: Introductionmentioning

confidence: 69%

Metagenome and metabolome insights into the energy compensation and exogenous toxin degradation of gut microbiota in high-altitude rhesus macaques (Macaca mulatta)

Zhao

Yao

et al. 2023

npj Biofilms Microbiomes

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There have been many reports on the genetic mechanism in rhesus macaques (RMs) for environmental adaptation to high altitudes, but the synergistic involvement of gut microbiota in this adaptation remains unclear. Here we performed fecal metagenomic and metabolomic studies on samples from high- and low-altitude populations to assess the synergistic role of gut microbiota in the adaptation of RMs to high-altitude environments. Microbiota taxonomic annotation yielded 7471 microbiota species. There were 37 bacterial species whose abundance was significantly enriched in the high-altitude populations, 16 of which were previously reported to be related to the host’s dietary digestion and energy metabolism. Further functional gene enrichment found a stronger potential for gut microbiota to synthesize energy substrate acetyl-CoA using CO2 and energy substrate pyruvate using oxaloacetate, as well as a stronger potential to transform acetyl-CoA to energy substrate acetate in high-altitude populations. Interestingly, there were no apparent differences between low-altitude and high-altitude populations in terms of genes enriched in the main pathways by which the microbiota consumed the three energy substrates, and none of the three energy substrates were detected in the fecal metabolites. These results strongly suggest that gut microbiota plays an important energy compensatory role that helps RMs to adapt to high-altitude environments. Further functional enrichment after metabolite source analysis indicated the abundance of metabolites related to the degradation of exogenous toxins was also significantly higher in high-altitude populations, which suggested a contributory role of gut microbiota to the degradation of exogenous toxins in wild RMs adapted to high-altitude environments.

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“…These explorations contribute to a deeper understanding of how TCM, through modulating gut microbiota, can offer therapeutic benefits, thus providing insights into new treatment strategies and drug discoveries. Most of the nine presentations at the iMeta Author Forum showcased eye-catching publications from the iMeta journal [8]. This forum explored various aspects of microbiome analysis, bioinformatics visualization, and the development of analytical tools [9].…”

Section: Gut and Traditional Chinese Medicine (Tcm)mentioning

confidence: 99%

Conference report: CHINAGUT 2023

2023

iMeta

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The CHINAGUT Conference, a biennial event dedicated to gut science, has grown significantly since its inception in 2018. Its 4th iteration, CHINAGUT 2023, was held from May 19 to 22 at the Beijing National Convention Center, attracting over 10,000 attendees. This large-scale academic interchange, organized by numerous academic and industrial entities, has become China's premier conference on gut-related research. This year's conference showcased an evolved content structure with a comprehensive call for submissions, channeling over 60% of oral presentations from submitted abstracts. The conference was organized into 14 major academic tracks reflecting hot research fields

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iMeta: Integrated meta‐omics for biology and environments

Cited by 16 publications

References 34 publications

Microbiome research outlook: past, present, and future

Microbiome research outlook: past, present, and future

Metagenome and metabolome insights into the energy compensation and exogenous toxin degradation of gut microbiota in high-altitude rhesus macaques (Macaca mulatta)

Conference report: CHINAGUT 2023

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