Imidazole Nucleosides and Nucleotides

Purine nucleosides XXVIII. The synthesis of 7‐(2′‐deoxy‐α‐ and β‐d‐ribofuranosyl)purines from 2′‐deoxyribofuranosylimidazoles. Preparation of the 2′‐deoxy derivative of the nucleoside from pseudovitamin B12 factor G

“…However, this approach, fusion of a preformed purine, did not appear to be suitable for the preparation of 7-(2'-deoxya-and P-D-ribofuranosy1)purines. The chemical synthesis of imidazole 2'-deoxynucleosides has not yet been accomplished (9) although these compounds might serve as valuable precursors (5,lO) in the synthesis of 7-(2'-deoxy-D-ribofuranosyl)purines. This prompted us to investigate the possibility of utilizing the fusion method of glycosidation to obtain imidazole 2'-deoxynucleosides from which we now wish to report the first synthetic preparation of 7-(2'-deoxy-a and P-D-ribofuranosyI)purines.…”

Functionalization of carboxylated multiwall nanotubes with imidazole derivatives and their toxicity investigations

“…Incorporation of imidazole and benzimidazole nuclei is an important synthetic strategy in drug discovery. 1 Observations suggest that substituted benzimidazoles and related heterocycles, which are the structural isosteres of nucleotides owing to fused heterocyclic nuclei in their structures, allow them to interact easily with biopolymers, and possess potential activity with lower toxicity in the chemotherapeutic approach in man. 2,3 The high therapeutic properties of related drugs have encouraged medicinal chemists to synthesize a large number of novel chemotherapeutic agents.…”

One-Pot Synthesis of 2-Alkyl-4(5)-Aryl-1H-Imidazoles from 1-Aryl-2-Bromoethanones, Ammonium Carbonate and Aliphatic Carboxylic Acids

“…The imidazole nucleus is incorporated in a variety of molecules, many of which are of biological interest, such as vitamin B12, 1 histidine, 2 nucleosides and nucleotides. 3 Imidazole derivatives are widely employed as antinociceptive agents, 4 anti-hypertensive drugs, 5 and ionic liquids. 6 The syntheses of imidazole derivatives reported in the literature generally require several steps.…”