Imipramine hyperpigmentation: A slate-gray discoloration caused by long-term imipramine administration

Hashimoto, Ken; Joselow, Steve A.; Tye, Mauray J.

doi:10.1016/0190-9622(91)70204-f

Cited by 34 publications

(33 citation statements)

References 10 publications

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“…hydantoins) are also known to increase pigmentation and might do so by a direct stimulatory action on melanocytes [52]. Tricyclic depressants (desipramine and imipramine) are associated with slate-gray pigmentation in sun-exposed areas caused both by increased melanin in the dermis as well as by electron-dense inclusions within dermal cells [53,54].…”

Section: Induction Of Hyperpigmentation -Specific Mechanismsmentioning

confidence: 99%

Modifying skin pigmentation – approaches through intrinsic biochemistry and exogenous agents

Brenner

Hearing

2008

Drug Discovery Today: Disease Mechanisms

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Rates of skin cancer continue to increase despite the improved use of traditional sunscreens to minimize damage from ultraviolet radiation. The public perception of tanned skin as being healthy and desirable, combined with the rising demand for treatments to repair irregular skin pigmentation and the desire to increase or decrease constitutive skin pigmentation, arouses great interest pharmaceutically as well as cosmeceutically. This review discusses the intrinsic biochemistry of pigmentation, details mechanisms that lead to increased or decreased skin pigmentation, and summarizes established and potential hyper-and hypo-pigmenting agents and their modes of action.

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Section: Induction Of Hyperpigmentation -Specific Mechanismsmentioning

confidence: 99%

Modifying skin pigmentation – approaches through intrinsic biochemistry and exogenous agents

Brenner

Hearing

2008

Drug Discovery Today: Disease Mechanisms

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“…The increased body weight with lower doses might be due to general increase in appetite as has been shown for varieties of other antidepressants in humans (Harris et al, 1987). In addition to body weight deficit, the higher dose of imipramine also induced alopecia, tremor and hyperpigmentation in rats which have all been clinically confirmed in case of humans (Baral, 1987;Hashimoto, 1991).…”

Section: Discussionmentioning

confidence: 81%

Comparative effect of therapeutic and toxic doses of imipramine administration on the levels of norepinephrine, dopamine and serotonin in discrete regions of rat brain

Meshkibaf¹,

Subhash²,

Hosseinzadeh³

et al. 2005

Biogenic Amines

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Levels of norepinephrine (NE), dopamine (DA) and 5-hydroxytryptamine (5-HT) were estimated by HPLC in different regions of adult rat brain after feeding therapeutic (25 mg/kg) or toxic (100 mg/kg) doses of imipramine for 60 days. Imipramine (25 mg/kg) significantly enhanced the growth rate compared to control but the 100 mg/kg dose significantly reduced the body growth rate (but not brain weight) and in addition induced tremors, lethargy, hyperpigmentation and alopecia.Imipramine, 25 mg/kg, consistently decreased the levels of NE in cortex, striatum-accumbens, cerebellum and brainstem by about 24% (p < 0.01) and decreased DA levels in cortex, hippocampus and hypothalamus (p = 0.01). 5-HT levels were decreased in cortex, striatum-accumbens, hippocampus and brainstem by about 20% (p < 0.01) in imipramine-treated rats. On the contrary, 100 mg/kg of imipramine consistently increased NE levels in cortex, striatum-accumbens, hypothalamus (p < 0.01) and cerebllum (p < 0.05) and increased DA levels only in cerebllum by 39% (p = 0.01). Increased 5-HT levels were seen in all brain regions, of imipraminefed rats, by about 20% (p < 0.01). This study shows that the effects of imipramine on monoamine levels in brain is both region specific and dose dependent. The results suggest that decreased monoamine levels at 25 mg/kg of imipramine in humans might be responsible for the antidepressant effect of imipramine, and increased monoamine levels at higher doses might be responsible for various CNS toxic symptoms observed in patients with high doses of imipramine.

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“…Increased pigmentation of the iris was reported in two patients. [4][5][6] There were also two patients who had pigmentation changes of their sclera that was reported to have amber 5 and brownish discoloration. 1 The outcome was specified in six patients.…”

Section: Discussionmentioning

confidence: 95%

“…[1][2][3][4][5][6][7] All were adults treated for depression, their ages ranging from 46 to 75 years. It should be noted that nine patients were female, 2-6 perhaps reflecting the higher incidence of depression in women.…”

Section: Discussionmentioning

confidence: 99%

Imipramine-Induced Facial Pigmentation: Case Report and Literature Review

2005

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Imipramine hyperpigmentation: A slate-gray discoloration caused by long-term imipramine administration

Cited by 34 publications

References 10 publications

Modifying skin pigmentation – approaches through intrinsic biochemistry and exogenous agents

Modifying skin pigmentation – approaches through intrinsic biochemistry and exogenous agents

Comparative effect of therapeutic and toxic doses of imipramine administration on the levels of norepinephrine, dopamine and serotonin in discrete regions of rat brain

Imipramine-Induced Facial Pigmentation: Case Report and Literature Review

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