Imiquimod 5% Cream for Keloid Management

Berman, Brian; Villa, Adriana M.

doi:10.1097/00042728-200310000-00011

Cited by 16 publications

(25 citation statements)

References 5 publications

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“…15 Despite numerous hypotheses about keloid formation that have been investigated, its exact mechanism still has not been determined. Furthermore, a broad range of available treatment modalities have been used for keloid, including surgical excision, laser therapy, silicone therapy, intralesional corticosteroids, 5-fluorouracil and imiquimod, [16][17][18][19][20][21][22] but none are consistently effective in flattening existing keloid, relieving associated symptoms and reducing recurrence.…”

Section: Discussionmentioning

confidence: 99%

Effect of heat shock protein 47 on collagen accumulation in keloid fibroblast cells

et al. 2007

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Combined with our previous histological results, we propose that overexpression of HSP47 in keloid fibroblast cells could induce excessive collagen accumulation by enhancing synthesis and secretion of collagen, which not only presents a possible mechanism of keloid formation, but also offers a therapeutic potential of RNA interference to HSP47 for the treatment of keloid and other fibroproliferative disorders.

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Section: Discussionmentioning

confidence: 99%

Effect of heat shock protein 47 on collagen accumulation in keloid fibroblast cells

et al. 2007

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“…Some immunomodulators such as imiquimod induce the local synthesis and release of cytokines including IFN-a, IFN-g, IL-1, IL-6, and IL-8 after topical application. 24,25 In HTSs, the abundance of lymphocytes in the subpapillary dermis and in the epidermal layers correlates well with the expression of ICAM-1 and HLA Class II on keratinocytes, which are both necessary for the migration and retention of inflammatory cells. 1,6,14,22 These antigen-independent adhesion molecules play an important role in cell-cell interactions associated with T-cell differentiation and function.…”

Section: Epidermal Responsementioning

confidence: 99%

Keloids and Hypertrophic Scars: Are They Two Different Sides of the Same Coin?

Köse

Waseem

2008

Dermatol Surg

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Keloids and hypertrophic scars are different forms of excessive dermal fibrosis thought to be caused by regulation of cellularity increase and decrease during the wound-healing process in predisposed individuals. Differences between keloids and hypertrophic scars include distinct clinical features, histologic evidence, and cellular function in response to molecular events. Keloids and hypertrophic scars are the results of increased fibroblast density and extracellular matrix substances. Interactions between epidermal keratinocytes and dermal fibroblasts play an important role in regulating tissue homeostasis and processing scar formation. Keloids and hypertrophic scars are the two different stages of the same process that is based on separate clinical and histochemical entities. The aim of this review is to provide updated information regarding similarities and differences between keloids and hypertrophic scars as two different sides of the same coin. This article will also enable the dermatologist to better understand fundamental biology of the scarring.

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“…Since its introduction, imiquimod has been used to treat numerous benign and malignant dermatologic conditions, including granuloma annulare, keloids, morphea, and lentigo maligna. [2][3][4][5] Although not yet approved by the FDA for the treatment of other subtypes of basal cell carcinoma, the drug's efficacy has been reported in the treatment of nodular basal cell carcinomas and in one report of a sclerodermiform basal cell carcinoma. [6][7][8] Imiquimod activates both innate and cell-mediated immunity by induction of various cytokines.…”

Section: Discussionmentioning

confidence: 99%