No abstract

Extramammary Paget's disease (EMPD) of the skin is an uncommon malignancy involving the epidermis, which sometimes extends into the dermis. Current treatments for EMPD are surgical excision, Mohs' micrographic surgery or laser ablation. We report a case of a 68-year-old male who presented with recurrent EMPD. The patient refused to have surgery and, as an alternative, he applied imiquimod 5% cream, an immune response modifier, daily for a total of 6 weeks. During the initial weeks of therapy, he experienced moderate erythema. Imiquimod treatment resulted in clinical and histological eradication of EMPD, with no recurrence observed during 6 months of follow-up.

BACKGROUND. Keloid treatment represents a therapeutic challenge. New adjuvant therapy is needed to reduce the high recurrence rate (50%) of excised keloids. OBJECTIVE. To describe the method for using imiquimod 5% cream in the prevention of keloid recurrence after surgery.METHODS. This is a review of the scientific rationale and clinical experience of using imiquimod 5% cream for keloid management. CONCLUSION. Topical application of imiquimod 5% cream after surgery reduces keloid recurrences.

Topical application of imiquimod 5% cream after surgery reduces keloid recurrences.