Successful treatment of extramammary Paget's disease of the scrotum with imiquimod 5% cream

Berman, Brian; Spencer, James M.; Villa, Adriana M.; Poochareon, Varee N.; Elgart, George W.

doi:10.1046/j.1365-2230.28.s1.12.x

Cited by 51 publications

(31 citation statements)

References 14 publications

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“…[19][20] Imiquimod 5% cream was successfully used in two series. 8,21 The efficacy of carbon dioxide laser treatment remains open to question. 6,22 After extended research and exploration, our institution established a standard surgical procedure for penoscrotal EMPD, which includes a staging system, frozen biopsy protocol, current techniques of repair and reconstruction and standard follow-up methods.…”

Section: Complicationsmentioning

confidence: 99%

Penoscrotal extramammary Paget's disease: surgical techniques and follow-up experiences with thirty patients

Chen¹,

Chen²,

Wang³

et al. 2013

Asian J Androl

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To report the surgical management, complications and prognosis of patients with penoscrotal extramammary Paget's disease (EMPD) at different clinical stages. Between 2003 and 2008, a total of 30 male patients with penoscrotal EMPD were enrolled and evaluated. All enrolled subjects received frozen biopsy-guided local wide resection and immediate reconstruction. Patients were followed every 3 months postoperatively. Among the 30 patients who accepted and underwent frozen biopsy-guided local wide resection treatment and reconstruction, two (6.7%) cases exhibited positive margins, verified by pathological examination, and underwent re-excision after surgery. The technique of primary closure or an adjacent flap was used in 10 (33.3%) cases, split-thickness skin grafts were used in 15 (50%), and an anterolateral thigh perforator flap was used in five cases (16.7%). The postoperative complications were acceptable. The mean follow-up time was 64.9629.6 months. Of all 30 cases, 22 patients (73.3%) survived with no evidence of recurrence, four patients (13.3%) exhibited local recurrence, two patients (6.7%) exhibited both local recurrence and distant metastasis and the remaining two patients (6.7%) exhibited distant metastasis. Five patients died from metastasis or cachexia. Current surgical techniques, including primary closure, adjacent flaps, split-thickness skin flaps and anterolateral thigh perforator flaps are able to reconstruct all types of defects with acceptable complications. Some patients with negative margins went on to exhibit local recurrence, potentially due to adnexal carcinoma or internal malignancy.

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Section: Complicationsmentioning

confidence: 99%

Penoscrotal extramammary Paget's disease: surgical techniques and follow-up experiences with thirty patients

Chen¹,

Chen²,

Wang³

et al. 2013

Asian J Androl

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“…Zampogna et al [30] berichteten erstmals 2002 über erfolgreiche ImiquimodTherapien des EMP bei 2 Patienten. In der uns zur Verfügung stehenden Literatur fanden sich insgesamt 22 Kasuistiken über Behandlungen des EMP mit 5% Imiquimod-Creme [2,3,4,5,6,9,13,16,17,20,26,27,29,30], . Tab.…”

Section: Diskussionunclassified

Extramammärer Morbus Paget

2011

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A 90-year-old woman presented with an extensive primary form of extramammary Paget disease localized in the anogenital region. An associated carcinoma could be excluded. Due to the age of the patient, the location and extent of the tumor as well as existing comorbidities, neither a surgical nor a radio-oncological treatment were advisable. A local treatment with imiquimod 5% cream applied 3 times weekly for 2 × 3 weeks led to a clinically and histopathologically complete remission. As also shown by other authors, imiquimod appears to be a treatment option for the primary form of extramammary Paget disease.

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“…3 Topical application of imiquimod 5% cream has been reported in the last years with successful results. [3][4][5][6][7][8][9][10][11][12][13][14] We report the case of a woman with primary vulvar Paget's disease, who underwent successful treatment with imiquimod cream, and review the published cases with EMPD treated to date with this therapy.…”

Section: Introductionmentioning

confidence: 99%

Treatment of vulvar Paget disease with topical imiquimod: a case report and review of the literature

Feldmeyer¹,

Kerl²,

Kamarashev³

et al. 2011

J Dermatol Case Rep

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Background: Extramammary Paget's disease is a cutaneous neoplasm that presents as erythematous crusted patches and plaques reminiscent of contact dermatitis or inverse psoriasis that can be a challenge to treat in a tissue-sparing manner. The most commonly involved site for this rare disorder is the anogenital region. Surgery is considered as the gold standard therapy. In the last years, the topical use of imiquimod cream in the treatment of this condition has been reported.

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Successful treatment of extramammary Paget's disease of the scrotum with imiquimod 5% cream

Cited by 51 publications

References 14 publications

Penoscrotal extramammary Paget's disease: surgical techniques and follow-up experiences with thirty patients

Penoscrotal extramammary Paget's disease: surgical techniques and follow-up experiences with thirty patients

Extramammärer Morbus Paget

Treatment of vulvar Paget disease with topical imiquimod: a case report and review of the literature

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