Imiquimod-induced psoriasis-like inflammation in differentiated Human keratinocytes: Its evaluation using curcumin

Varma, Sandeep R.; Sivaprakasam, Thiyagarajan O.; Mishra, Abheepsa; Prabhu, Sunil; Rafiq, Mohammed; Rangesh, Paramesh

doi:10.1016/j.ejphar.2017.07.040

Cited by 80 publications

(53 citation statements)

References 38 publications

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“…During the last years some laboratory and clinical studies have investigated the therapeutic potential of curcumin in psoriasis. Curcumin may improve psoriasis by inhibition of phosphorylase kinase [35,36], downregulation of pro-inflammatory cytokines such as IL-17 and TNF-α, as well as improvement of the epidermal barrier by inducing the expression of involucrin and filaggrin in vitro [37]. However, randomized placebo-controlled studies with turmeric and curcumin in psoriasis are missing so far [38].…”

Section: Turmeric (Curcuma Longa (L))mentioning

confidence: 99%

New Herbal Biomedicines for the Topical Treatment of Dermatological Disorders

et al. 2020

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Herbal extracts and isolated plant compounds play an increasing role in the treatment of skin disorders and wounds. Several new herbal drugs, medicinal products and cosmetic products for the treatment of various skin conditions have been developed in recent years. In this nonsystematic review, we focus on herbal drugs that were tested in controlled clinical studies or in scientifically sound preclinical studies. The herbal biomedicines are intended to treat atopic dermatitis (St. John’s wort, licorice, tormentil, bitter substances, evening primrose), psoriasis (araroba tree, lace flower, barberry bark, indigo, turmeric, olibanum, St. John’s wort), actinic keratosis (birch bark, petty spurge), herpes simplex (lemon balm, sage and rhubarb), rosacea (green tea, licorice, tormentil) and acne vulgaris (tea tree oil, green tea, hop), or to improve photo protection (green tea, Dyer’s weed, cocoa tree, carotinoids, licorice), aesthetic dermatology (licorice, pine bark, gotu kola) and wound healing (birch bark, onion).

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Section: Turmeric (Curcuma Longa (L))mentioning

confidence: 99%

New Herbal Biomedicines for the Topical Treatment of Dermatological Disorders

et al. 2020

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“…Hier scheinen verschiedene Mechanismen, wie die Inhibition der Phosphorylase-Kinase [38,39], das Herunterregulieren von proinflammatorischen Zytokinen (wie bspw. von IL-17 und von TNF-α) sowie die Stärkung der Barrierefunktion der Haut durch das Hochregulieren von Involucrin und Fillagrin in vitro eine Rolle zu spielen [40]. Es werden jedoch weitere, placebokontrollierte, klinische Studien benötigt, bevor eine Empfehlung zur Anwendung topischer und oraler Kurkuma-Präparate in der Psoriasis ausgesprochen werden kann [41].…”

Section: Kurkuma (Curcuma Longa)unclassified

Phytotherapie bei entzündlichen Hauterkrankungen

2019

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ZusammenfassungIn den letzten Jahren wurden einige neue pflanzliche Arzneimittel, Medizinprodukte und Hautpflegemittel für die topische Behandlung von entzündlichen Hauterkrankungen entwickelt. Besonders gut belegt ist die Wirksamkeit von Inhaltsstoffen aus dem Süßholz bei der atopischen Dermatitis und von Indigoextrakten bei der Psoriasis. Ein neuer vielversprechender Therapieansatz zur äußerlichen Behandlung einer geschädigten Hautbarriere sind Bitterstoffe, die an Bitterstoffrezeptoren der Haut binden und die Keratin- und Lipidsynthese der Keratinozyten anregen. Weitere pflanzliche Wirkstoffe für die Behandlung von Rosazea und Akne vulgaris werden ebenfalls besprochen.

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“…The authors showed how curcumin was able to inhibit the proliferation of psoriatic - like cells, by the down-regulation of pro-inflammatory cytokines, such as interleukin - 17, tumour necrosis factor - α, interferon - γ and interleukin - 6. Moreover, curcumin significantly enhanced the skin - barrier function by the up-regulation of involucrin (iNV) and filaggrin (FLG) [ 21 ].…”

Section: Curcumin and Psoriasismentioning

confidence: 99%