2012
DOI: 10.1186/1477-7827-10-18
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Immature rat seminal vesicles show histomorphological and ultrastructural alterations following treatment with kisspeptin-10

Abstract: BackgroundDegenerative effects of critical regulators of reproduction, the kisspeptin peptides, on cellular aspects of sexually immature male gonads are known but similar information on accessory sex glands remain elusive.MethodsPrepubertal laboratory rats were injected kisspeptin-10 at three different dosage concentrations (10 pg, 1 ng and 1 microgram) for a period of continuous 12 days at the rate of two doses per day. Control rats were maintained in parallel. The day following the end of the experimental pe… Show more

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Cited by 12 publications
(10 citation statements)
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“…The present study indicate that serum kisspeptin level does not influence the semen volume suggesting there is not major positive effect of kisspeptin on accessory sex gland. Previous studies also indicating that continuous administration of kisspeptin does not lead to an early maturation but instead severe degeneration of sexually immature seminal vesicles (Ramzan, Qureshi, Ramzan, Ramzan, & Ramzan, 2012) and prostate gland (Ramzan, Khan, Ramzan, & Ramzan, 2013; Ramzan & Ramzan, 2017) in rat. In this study, higher serum kisspeptin in buffalo bulls with higher sperm concentration hints the link of kisspeptin with spermatogenesis.…”
Section: Discussionmentioning
confidence: 89%
“…The present study indicate that serum kisspeptin level does not influence the semen volume suggesting there is not major positive effect of kisspeptin on accessory sex gland. Previous studies also indicating that continuous administration of kisspeptin does not lead to an early maturation but instead severe degeneration of sexually immature seminal vesicles (Ramzan, Qureshi, Ramzan, Ramzan, & Ramzan, 2012) and prostate gland (Ramzan, Khan, Ramzan, & Ramzan, 2013; Ramzan & Ramzan, 2017) in rat. In this study, higher serum kisspeptin in buffalo bulls with higher sperm concentration hints the link of kisspeptin with spermatogenesis.…”
Section: Discussionmentioning
confidence: 89%
“…Kp10, in a dose-dependent manner, positively stimulated, proliferative (ID4 and MVH) and differentiative markers (SCP3 and c-Kit) in spermatogonial cells from adult azoospermic and new-born mice cocultured with somatic cells [48]. Additionally, the effect of kisspeptin administration on accessory gland structure, seminal vesicle and prostate have also been documented [69]. Fructose is released from seminal vesicles, and its levels are reflective of seminal vesical function, with fructose metabolic pathways observed in mice spermatozoa.…”
Section: Effects Of Kisspeptin On Sperm Functionmentioning
confidence: 89%
“…DNA was isolated according to the method of Gilbert et al 18 as described in detail in Ramzan et al 17.…”
Section: Methodsmentioning
confidence: 99%
“…DNA quantification was done according to the method of Boraschi and Maurizi 19 as documented in Ramzan et al 17. The percentage of fragmented DNA was calculated using the formula: …”
Section: Methodsmentioning
confidence: 99%