Immediate adverse reactions to acetaminophen in children: Evaluation of histamine release and spirometry

Hypersensitivity reactions to paracetamol in children: a study of 25 cases

“…Although paracetamol (acetaminophen) is widely used, HS‐like reactions to this drug are rare, especially in children (3, 4). However, immediate and accelerated urticaria and/or angioedema, dyspnea and rhinitis (3–8), and rare allergic and nonallergic anaphylactic reactions (3, 9–12), have been reported in children and adults. Most reactions to paracetamol occur in patients with a nonallergic HS to nonsteroidal anti‐inflammatory drugs (NSAIDs) (13, 14).…”

Anaphylaxis to Paracetamol in a Twelve-Year-Old Girl

“…We reviewed the literature, and to the best of our knowledge, only 11 studies, including this report, have reported anaphylaxis to paracetamol in a total of 12 children (< 18 years old) ( Table 1). [2][3][4][5][6][7][8][9][10][11] Among these children, the diagnosis has been confirmed by a positive oral challenge (or accidental re-exposure) in all but one child.…”

Does paracetamol cause asthma?

“…If there was a strong link between paracetamol consumption and asthma, it would be surprising if it was not well known by now. In fact there are very few reports of paracetamol actually causing asthma (51–53) and bronchospasm is not a recognized feature of paracetamol overdosage, a clinical problem that is common and has been well studied. Nevertheless, the evidence presented in this review suggests that those who regularly take paracetamol may be more likely to suffer from asthma and this observation might be explained on the basis that paracetamol depletes lung glutathione thereby reducing lung defences against free radical damage.…”