Immediate and cumulative effects of high-frequency repetitive transcranial magnetic stimulation on cognition and neuronal excitability in mice

Zhu, He; Xu, Guizhi; Yang, Li; Fu, Rui; Yin, Xiaonan; Xu, Baohong; Ding, Chong

doi:10.1016/j.neures.2021.05.015

Cited by 7 publications

(2 citation statements)

References 36 publications

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“…The application of rTMS can lead to changes in both the local area being stimulated and distal areas connected to it, leading to alterations in neural networks. As the number of rTMS sessions increases, these neural adaptations accumulate, potentially leading to more significant and sustained therapeutic effects (64). Studies have shown that patients with constipation are often accompanied by psychiatric symptoms such as anxiety and depression (30).…”

Section: Discussionmentioning

confidence: 99%

The role of repetitive transcranial magnetic stimulation therapy in functional bowel disease

Li,

Lv,

Jin

et al. 2023

Front. Med.

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ObjectiveThis study investigates the effectiveness of repetitive transcranial magnetic stimulation (rTMS) as a biophysical therapy for alleviating symptoms of functional bowel disorder (FBD) and associated psychological symptoms by targeting the brain-gut axis.MethodsWe conducted a comparative analysis involving 226 subjects, comprising the FBD group (n = 113) and a healthy control group (n = 113). Within the FBD group, participants were further divided into those who received rTMS therapy (FBD treatment group, n = 63) and those who did not (FBD control group, n = 50). The FBD treatment group was subcategorized based on the number of rTMS treatments received. We evaluated various factors, including gender, age, monthly household income, daily activity level, and sleep quality, as potential risk factors for FBD. Severity assessments of FBD and associated symptoms (constipation, anxiety, depression, and somatization disorders) were conducted using validated scales before and after treatment.ResultsOur findings revealed a higher incidence of FBD in women, with most cases emerging at age 50 or older. We identified lower monthly household income, reduced daily activity levels, and poorer sleep quality as factors associated with a higher likelihood of FBD. FBD patients exhibited higher scores for constipation, anxiety, depression, and somatization disorders compared to healthy controls. rTMS therapy was effective in reducing gastrointestinal symptoms, anxiety, depression, and somatization disorders among FBD patients. Notably, the extent of improvement was positively correlated with the number of rTMS sessions. No adverse effects were observed during the study.ConclusionOur study underscores the efficacy of biophysical therapy, specifically repetitive transcranial magnetic stimulation, in mitigating FBD symptoms and associated psychological distress. The treatment’s effectiveness is positively linked to the frequency of rTMS sessions.

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Section: Discussionmentioning

confidence: 99%

The role of repetitive transcranial magnetic stimulation therapy in functional bowel disease

Li,

Lv,

Jin

et al. 2023

Front. Med.

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“…Step-Down Test. The step-down test was performed in a plastic box with a floor that contains parallel stainless-steel rods and a rubber platform as the method of Zhu et al 19 with some modifications. During the adaptive phase, each mouse was placed on the platform for 3 min to accommodate the room.…”

Section: ■ Materials and Methodsmentioning

confidence: 99%

Novel Selenium Peptides Obtained from Selenium-Enriched Cordyceps militaris Alleviate Neuroinflammation and Gut Microbiota Dysbacteriosis in LPS-Injured Mice

Wang

et al. 2022

J. Agric. Food Chem.

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Increasing attention focuses on the relationship between neuroinflammation and Alzheimer’s disease (AD). The reports on the microbiota–gut–brain axis reveal that the regulation by gut microbiota is an effective way to intervene in neuroinflammation-related AD. In this study, two novel selenium peptides (Se-Ps), VPRKL(Se)M (Se-P1) and RYNA(Se)MNDYT (Se-P2), with neuroprotection effects were obtained from Se-enriched Cordyceps militaris. Se-P1 and Se-P2 pre-protection led to a 30 and 33% increase in the PC-12 cell viability compared to the damage group, respectively. Moreover, Se-Ps exhibited a significant pre-protection against LPS-induced inflammatory and oxidative stress in the colon and brain by inhibiting the production of pro-inflammatory mediators (p < 0.05) and malondialdehyde, as well as promoting anti-inflammatory cytokine level and antioxidant enzyme activity (p < 0.05), which may alleviate the cognitive impairment in LPS-injured mice (p < 0.05). Se-Ps not only repaired the intestinal mucosa damage of LPS-injured mice but also had a positive effect on gut microbiota dysbacteriosis by increasing the abundance of Lactobacillus and Alistipes and decreasing the abundance of Akkermansia and Bacteroides. Collectively, the antioxidant, anti-inflammatory, and regulating properties on gut microflora of Se-Ps contribute to their neuroprotection, supporting that Se-Ps could be a promising dietary supplement in the prevention and/or treatment of AD.

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Effects of rTMS on Brain Injury Induced by Cranial Irradiation in Mice

Qin,

Liu,

Guo

et al. 2023

Lecture Notes in Electrical Engineering

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Immediate and cumulative effects of high-frequency repetitive transcranial magnetic stimulation on cognition and neuronal excitability in mice

Cited by 7 publications

References 36 publications

The role of repetitive transcranial magnetic stimulation therapy in functional bowel disease

The role of repetitive transcranial magnetic stimulation therapy in functional bowel disease

Novel Selenium Peptides Obtained from Selenium-Enriched Cordyceps militaris Alleviate Neuroinflammation and Gut Microbiota Dysbacteriosis in LPS-Injured Mice

Effects of rTMS on Brain Injury Induced by Cranial Irradiation in Mice

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