Immediate postoperative Fibrosis-4 predicts postoperative liver failure for patients with hepatocellular carcinoma undergoing curative surgery

Wang, Haiqing; Li, Lei; Bo, Wentao; Liu, Aixiang; Xu, Feng; Hu, Yong; Tian, Lei; Zhang, Hui; Tang, Xiaoli; Zhang, Lixia; Zhang, Mingyi

doi:10.1016/j.dld.2017.09.127

Cited by 7 publications

(1 citation statement)

References 22 publications

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“…Recent studies have reported that postoperative complications depend on liver function reserve and perioperative nutritional status [ 25 – 29 ]. Perioperative nutritional supplementation may thus reduce the risk of postoperative complications and shorten the duration of hospitalisation for patients with cancer requiring liver resection [ 30 – 32 ].…”

Section: Discussionmentioning

confidence: 99%

Preoperative prognostic nutritional index predicts postoperative infectious complications and oncological outcomes after hepatectomy in intrahepatic cholangiocarcinoma

et al. 2021

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Background In the surgical treatment of intrahepatic cholangiocarcinoma (ICC), postoperative complications may be predictive of long-term survival. This study aimed to identify an immune-nutritional index (INI) that can be used for preoperative prediction of complications. Patients and methods Multi-institutional data from 316 patients with ICC who had undergone surgical resection were retrospectively analysed, with a focus on various preoperative INIs. Results Severe complications (Clavien-Dindo grade III–V) were identified in 66 patients (20.8%), including Grade V complications in 7 patients (2.2%). Comparison of areas under the receiver operating characteristic curve (AUCs) among various INIs identified the prognostic nutritional index (PNI) as offering the highest predictive value for severe complications (AUC = 0.609, cut-off = 50, P = 0.008). Multivariate analysis revealed PNI < 50 (odds ratio [OR] = 2.22, P = 0.013), hilar lesion (OR = 2.46, P = 0.026), and long operation time (OR = 1.003, P = 0.029) as independent risk factors for severe complications. In comparing a high-PNI group (PNI ≥ 50, n = 142) and a low-PNI group (PNI < 50, n = 174), the low-PNI group showed higher rates of both major complications (27% vs. 13.4%; P = 0.003) and infectious complications (14.9% vs. 3.5%; P = 0.0021). Furthermore, median survival time and 1- and 5-year overall survival rates were 34.2 months and 77.4 and 33.8% in the low-PNI group, respectively, and 52.4 months and 89.3 and 47.5% in the high-PNI group, respectively (P = 0.0017). Conclusion Preoperative PNI appears useful as an INI correlating with postoperative severe complications and as a prognostic indicator for ICC.

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Section: Discussionmentioning

confidence: 99%

Preoperative prognostic nutritional index predicts postoperative infectious complications and oncological outcomes after hepatectomy in intrahepatic cholangiocarcinoma

et al. 2021

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The preoperative fibrosis score 4 predicts posthepatectomy liver failure in patients with hepatocellular carcinoma

Feng

et al. 2019

Annals of Hepatology

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Is immediate postoperative fibrosis-4 really a good predictor of liver failure following hepatocellular carcinoma curative surgery?

Xue

Liu

et al. 2018

Digestive and Liver Disease

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Immediate postoperative Fibrosis-4 predicts postoperative liver failure for patients with hepatocellular carcinoma undergoing curative surgery

Abstract: Immediate postoperative Fibrosis-4 showed good prediction ability for postoperative liver failure, and required measure should be taken to prevent liver failure when high postoperative Fibrosis-4 appeared.

Cited by 7 publications

References 22 publications

Preoperative prognostic nutritional index predicts postoperative infectious complications and oncological outcomes after hepatectomy in intrahepatic cholangiocarcinoma

Preoperative prognostic nutritional index predicts postoperative infectious complications and oncological outcomes after hepatectomy in intrahepatic cholangiocarcinoma

The preoperative fibrosis score 4 predicts posthepatectomy liver failure in patients with hepatocellular carcinoma

Is immediate postoperative fibrosis-4 really a good predictor of liver failure following hepatocellular carcinoma curative surgery?

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