Immediate results of photodynamic therapy for the treatment of halitosis in adolescents: a randomized, controlled, clinical trial

Lopes, Rubia Garcia; Mota, Ana Carolina Costa da; Soares, Carolina Pontes; Tárzia, Olinda; Deana, Alessandro Melo; Prates, Renato Araújo; França, Cristiane Miranda; Fernandes, Kristianne Porta Santos; Mesquita‐Ferrari, Raquel Agnelli; Bussadori, Sandra Kalil

doi:10.1007/s10103-015-1822-6

Cited by 31 publications

(47 citation statements)

References 34 publications

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“…Antimicrobial PDT was performed with the THERAPY XT‐EC ® device (DMC ABC Equipamentos Médicos e Odontológicos, São Paulo, Brazil), with red laser emission (660 nm) and a beam spot area of 0.094 cm with in an irradiated area of 0.254 cm 2 per point . A single session of antimicrobial PDT was performed with 0.005% methylene blue (Fórmula e Ação, São Paulo, Brazil) applied to the middle and posterior portions of the tongue for 5 minutes of pre irradiation time.…”

Section: Methodssupporting

confidence: 93%

Effect of photodynamic therapy for the treatment of halitosis in adolescents – a controlled, microbiological, clinical trial

Mota¹,

França²,

Prates³

et al. 2016

Journal of Biophotonics

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Halitosis can exert a negative influence on the social relations of adolescents and affect one's self-image. The aim of this study was to evaluate the clinical and microbiological effect of antimicrobial photodynamic therapy (aPDT) on halitosis in adolescents. Forty-six individuals aged 12 to 19 years were randomly allocated: Group 1 - treatment with photodynamic therapy; Group 2 - treatment with a tongue scraper and Group 3 - treatment with a tongue scraper and photodynamic therapy. The count of bacterial colony-forming units per milliliter was used for the microbiological analysis. Statistical analysis involved the Kruskal-Wallis test followed by the Student-Newman-Keuls test. ANOVA was used for the determination of colony-forming units after treatment. The level of significance for all statistical tests was 5% (p < 0.05). After treatment, a statistically significant reduction in total volatile sulfur compounds was found in all groups (p < 0.001), with the largest reduction (median: 0) found in Group 3 (tongue scraper and photodynamic therapy). Moreover, a statistically significant difference was found between treatment with aPDT and a tongue scraper alone (p < 0.001). The present findings demonstrate an option for the treatment of halitosis in adolescents, with an immediate effect and without the mechanical aggression to the toungue. Clinical Trials: NCT02007993.

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Section: Methodssupporting

confidence: 93%

Effect of photodynamic therapy for the treatment of halitosis in adolescents – a controlled, microbiological, clinical trial

Mota¹,

França²,

Prates³

et al. 2016

Journal of Biophotonics

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“…Also, it has been suggested that the use of antimicrobial agents is associated with some collateral effects, such as unpleasant taste, staining effects and especially harm to normal oral microflora [ 31 ]. In contrast, aPDT has been proven as a good complementary treatment for this condition [ 7 , 20 – 22 ]. As opposed to conventional antimicrobial methods, aPDT has the advantages of being a non-invasive procedure, it does not result in undesired side effects, and the development of resistance by bacteria is unlikely [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

“…The results immediately after the different treatments are the most important ones, as they will really show their efficacy. Additionally, the investigations using aPDT for the treatment of halitosis show its effects immediately after treatment [ 7 , 21 , 22 ]. Furthermore, this trial was designed to be applied in the dental practice in the future, so the 7-day interval also represents a period in which patients could come back to the dental office, retake the halimetry and repeat the aPDT, if necessary.…”

Section: Discussionmentioning

confidence: 99%

“…Its use is being studied in several areas in dentistry, such as periodontics [ 16 ] and endodontics [ 17 ] and in the treatment of mucosa wounds [ 18 ] and caries [ 19 ]. aPDT has also been used in clinical trials for the reduction of halitosis with methylene blue and red lasers, and satisfactory results have been obtained [ 7 , 20 – 22 ].…”

Section: Introductionmentioning

confidence: 99%

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Photodynamic therapy with Bixa orellana extract and LED for the reduction of halitosis: study protocol for a randomized, microbiological and clinical trial

Gonçalves

Mota

Deana

et al. 2018

Trials

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BackgroundHalitosis is an unpleasant breath odour that can interfere with the professional life, social life and quality of life of people who suffer from it. A modality of treatment that has been increasing in dentistry is antimicrobial photodynamic therapy (aPDT). Bixa orellana, popularly known as “urucum” is a plant native to Brazil. The seeds are used to produce a dye that is largely used in the food, textile, paint and cosmetic industries. The aim of this study is to verify whether aPDT with Bixa orellana extract and blue light-emitting diodes (LEDs) is effective in reducing halitosis. This method will also be compared with tongue scraping, the most commonly used conventional method for tongue coating removal, and the association of both methods will be evaluated.Methods/designA randomized clinical trial will be conducted at the dental clinic of the Universidade Nove de Julho. Thirty-nine patients will be divided by block randomization into three groups (n = 13) according to the treatment to be performed. In Group 1, tongue scraping will be performed by the same operator in all patients for analysis of the immediate results. Patients will also be instructed on how to use the scraper at home. Group 2 will be treated with aPDT with Bixa orellana extract and the LED light curing device: Valo Cordless Ultradent®. Six points in the tongue dorsum with a distance of 1 cm between them will be irradiated. The apparatus will be pre-calibrated at wavelength 395–480 nm for 20 s and 9.6 J per point. In Group 3, patients will be submitted to the tongue scraping procedure, as well as to the previously explained aPDT. Oral air collection with the Oral Chroma™ and microbiological collections of the tongue coating shall be done before, immediately after and 7 days after treatment for comparison.DiscussionHalitosis treatment is a topic that still needs attention. The results of this trial could support decision-making by clinicians regarding aPDT using blue LEDs for treating halitosis on a daily basis, as most dentists already have this light source in their offices.Trial registrationClinicalTrials.gov, NCT03346460. Registered on 17 November 2017.Electronic supplementary materialThe online version of this article (10.1186/s13063-018-2913-z) contains supplementary material, which is available to authorized users.

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“…This reaction results in a phototoxic effect on microbes providing antimicrobial activity to the tissues exposed to PDT. The dorsal tongue is targeted and treated, resulting in an antimicrobial effect on odor causing microbes, thus reducing oral malodor (Costa da Mota et al 2016;Lopes et al 2014Lopes et al , 2016.…”

Section: Diagnostic Toolsmentioning

confidence: 99%

Halitosis

Thoppay¹,

Filippi²,

Ciarrocca³

et al. 2017

Contemporary Oral Medicine

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Halitosis, commonly known as bad breath, is an unpleasant symptom that can present as a social problem compromising quality of life. This condition may affect individuals of all ages and may be a transient episode or a longlasting problem depending on the cause. In some cases, patients may present with pseudo-halitosis, whereby there is a belief that they have bad breath despite their malodor not being perceived or detected, either by those around them or by objective analysis. Halitosis can occur due to local factors, or in rare cases be attributed to systemic etiologies. For patients who present with halitosis exclusively from local oral factors, improving oral health including tongue cleaning, treating dry mouth and alleviating local causes, may be beneficial. For patients with a systemic etiology for their halitosis, a multidisciplinary management approach may be necessary.

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Immediate results of photodynamic therapy for the treatment of halitosis in adolescents: a randomized, controlled, clinical trial

Abstract: Photodynamic Therapy in Adolescents Halitosis ( https://clinicaltrials.gov/ct2/show/NCT02007993?term=NCT02007993&rank=1 )Number: NCT02007993FUNDING:FAPESPNumber: 2013/13032-8.

Cited by 31 publications

References 34 publications

Effect of photodynamic therapy for the treatment of halitosis in adolescents – a controlled, microbiological, clinical trial

Effect of photodynamic therapy for the treatment of halitosis in adolescents – a controlled, microbiological, clinical trial

Photodynamic therapy with Bixa orellana extract and LED for the reduction of halitosis: study protocol for a randomized, microbiological and clinical trial

Halitosis

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