Immobilization of bioactive complex on the surface of magnesium alloy stent material to simultaneously improve anticorrosion, hemocompatibility and antibacterial activities

Pan, Changjiang; Zhao, Yongjuan; Yang, Ya; Yang, Minghui; Hong, Qinghui; Yang, Zhongmei; Zhang, Qiuyang

doi:10.1016/j.colsurfb.2020.111541

Cited by 21 publications

(12 citation statements)

References 42 publications

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“…The adverse reactions caused by rapid degradation behaviors after implantation, such as enrichment of Mg 2+ [ 36 ], local alkalization [ 37 ], and the by-corrosion products [ 38 ], can bring about the early loss of radial support, thus leading to the failure of implantation, mainly in the following three aspects: (a) too fast degradation behavior will lead to the failure of the stent due to the premature loss of radial support; (b) stent fracture and collapse caused by the uneven degradation behavior of Mg alloy can easily result in restenosis; (c) the uncontrollable degradation behavior of Mg alloy will produce huge amounts of hydrogen within a short time, which is unfavorable for the healing of neovascularization tissues. Therefore, effective control of the degradation behavior of Mg alloys is of great significance in the promotion of the clinical application of Mg-based stents [ 39 , 40 ].…”

Section: Introductionmentioning

confidence: 99%

Advances in coatings on magnesium alloys for cardiovascular stents – A review

Zhang

Yang

et al. 2021

Bioactive Materials

109

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Magnesium (Mg) and its alloys, as potential biodegradable materials, have drawn wide attention in the cardiovascular stent field because of their appropriate mechanical properties and biocompatibility. Nevertheless, the occurrence of thrombosis, inflammation, and restenosis of implanted Mg alloy stents caused by their poor corrosion resistance and insufficient endothelialization restrains their anticipated clinical applications. Numerous surface treatment tactics have mainly striven to modify the Mg alloy for inhibiting its degradation rate and enduing it with biological functionality. This review focuses on highlighting and summarizing the latest research progress in functionalized coatings on Mg alloys for cardiovascular stents over the last decade, regarding preparation strategies for metal oxide, metal hydroxide, inorganic nonmetallic, polymer, and their composite coatings; and the performance of these strategies in regulating degradation behavior and biofunction. Potential research direction is also concisely discussed to help guide biological functionalized strategies and inspire further innovations. It is hoped that this review can give assistance to the surface modification of cardiovascular Mg-based stents and promote future advancements in this emerging research field.

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Section: Introductionmentioning

confidence: 99%

Advances in coatings on magnesium alloys for cardiovascular stents – A review

Zhang

Yang

et al. 2021

Bioactive Materials

109

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“…The adhesion of cells by chitosan mainly on osteoblasts and fibroblasts has been widely reported in the literature. [ 40,41 ] The results revealed that C/G@AP/PPENK afforded a favorable surface for cell adhesion and proliferation.…”

Section: Resultsmentioning

confidence: 99%

Apatite Formation Induced by Chitosan/Gelatin Hydrogel Coating Anchored on Poly(aryl ether nitrile ketone) Substrates to Promote Osteoblastic Differentiation

Liu

et al. 2021

Macromolecular Bioscience

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Bone‐like apatite is a promising coating of poly(ether ether ketone) (PEEK) for bone implantation. Poly(aryl ether nitrile ketone) containing phthalazinone moiety (PPENK) is a novel alternative for its easy synthesis. Here, chitosan/gelatin hybrid hydrogel coating is applied to induce the formation of apatite on the surface of PPENK substrate through biomineralization to improve its biocompatibility and osteogenic property. PPENK possessing allyl groups (PPENK‐d) are synthesized and spin‐coated on PPENK substrate to impart reactive groups. The hydrogel coating is prepared by the ultraviolet crosslinking of gelatin methacrylate (GelMA) and chitosan methacrylate (CSMA) on PPENK substrate. PPENK‐d, GelMA, and CSMA are characterized by 1H‐NMR to confirm the designed structures. The presence of chitosan increases the chelation of calcium ions and thus induces the nucleation of apatite. The microstructural and compositional results reveal that the chitosan‐containing hydrogel coating induced apatite coating yields a higher apatite quantity compared to the gelatin hydrogel coating. The apatite coatings on PPENK substrate promote the cytocompatibility and osteogenesis of MC3T3‐E1 preosteoblasts in vitro.

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“…Bacterial growth will be inhibited bacteriostatically or bactericidal by these mechanisms, which may operate independently or in combination [26]. Among the various suggested mechanisms for GO's antimicrobial performance, mechanical destruction to bacteria membranes through sharp edges of GO when contacting directly with GO and the formation of reactive oxygen species (ROS) occurred when oxidative stress generated by GO and charge transfer are more circumstances [7,39]. MgO as another antibacterial agent reacts with intracellular oxygen to produce ROS such as H 2 O 2 , OH • and O 2…”

Section: Antibacterial Effectmentioning

confidence: 99%

“…Organic polymer material composite coating via sol-gel methods were employed on the magnesium alloy surface to reduce its degradation rate and further protect Mg alloy substrate exposed to the SBF [4,5]. The bacterial infections related to implants are increasing and should not be ignored [6][7][8]. The mentioned infections cause high medical costs and lead to higher suffering of patients.…”

Section: Introductionmentioning

confidence: 99%

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Dual Synergistic Effects of MgO-GO Fillers on Degradation Behavior, Biocompatibility and Antibacterial Activities of Chitosan Coated Mg Alloy

et al. 2022

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The aim of this work was to establish and characterize chitosan/graphene oxide- magnesium oxide (CS/GO-MgO) nanocomposite coatings on biodegradable magnesium-zinc-cerium (Mg-Zn-Ce) alloy. In comparison to that of pure CS coatings, all composite coatings encapsulating GO-MgO had better adhesion strength to the Mg-Zn-Ce alloy substrate. The result depicted that the co-encapsulation of GO-MgO into the CS layer leads to diminish of contact angle value and hence escalates the hydrophilic characteristic of coated Mg alloy. The electrochemical test demonstrated that the CS/GO-MgO coatings significantly increased the corrosion resistance because of the synergistic effect of the GO and MgO inside the CS coating. The composite coating escalated cell viability and cell differentiation, according to cytocompatibility tests due to the presence of GO and MgO within the CS. The inclusion of GO-MgO in CS film, on the other hand, accelerates the formation of hydroxyapatite (HA) during 14 days immersion in SBF. Immersion results, including weight loss and hydrogen evolution tests, presented that CS/GO-MgO coating enables a considerably reduced degradation rate of Mg-Zn-Ce alloy when compared to the bare alloy. In terms of antibacterial-inhibition properties, the GO-MgO/CS coatings on Mg substrates showed antibacterial activity against Escherichia coli (E. coli), with a large inhibition area around the specimens, particularly for the coating containing a higher concentration of GO-MgO. Bacterial growth was not inhibited by the bare Mg alloy samples. The CS/GO-MgO composite coating is regarded as a great film to enhance the corrosion resistance, bioactivity, and antibacterial performance of Mg alloy implants.

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Immobilization of bioactive complex on the surface of magnesium alloy stent material to simultaneously improve anticorrosion, hemocompatibility and antibacterial activities

Cited by 21 publications

References 42 publications

Advances in coatings on magnesium alloys for cardiovascular stents – A review

Advances in coatings on magnesium alloys for cardiovascular stents – A review

Apatite Formation Induced by Chitosan/Gelatin Hydrogel Coating Anchored on Poly(aryl ether nitrile ketone) Substrates to Promote Osteoblastic Differentiation

Dual Synergistic Effects of MgO-GO Fillers on Degradation Behavior, Biocompatibility and Antibacterial Activities of Chitosan Coated Mg Alloy

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