Immobilization of fine particles on lactose carrier by precision coating and its effect on the performance of dry powder formulations

Chan, Lai Wah; Lim, Liang Theng; Heng, Paul Wan Sia

doi:10.1002/jps.10372

Cited by 48 publications

(18 citation statements)

References 14 publications

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“…Thus it is possible to control the surface properties and related aerosol performance of lactose carrier by immobilizing the fines on their surfaces (70). This can be accomplished by fluidized bed coating of micronized lactose particles with dissolved lactose in spray solution (70).…”

Section: Blending and Formulation With Lactosementioning

confidence: 99%

Particle Engineering for Pulmonary Drug Delivery

et al. 2007

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With the rapidly growing popularity and sophistication of inhalation therapy, there is an increasing demand for tailor-made inhalable drug particles capable of affording the most efficient delivery to the lungs and the most optimal therapeutic outcomes. To cope with this formulation demand, a wide variety of novel particle technologies have emerged over the past decade. The present review is intended to provide a critical account of the current goals and technologies of particle engineering for the development of pulmonary drug delivery systems. These technologies cover traditional micronization and powder blending, controlled solvent crystallization, spray drying, spray freeze drying, particle formation from liquid dispersion systems, supercritical fluid processing and particle coating. The merits and limitations of these technologies are discussed with reference to their applications to specific drug and/or excipient materials. The regulatory requirements applicable to particulate inhalation products are also reviewed briefly.

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Section: Blending and Formulation With Lactosementioning

confidence: 99%

Particle Engineering for Pulmonary Drug Delivery

et al. 2007

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“…For example, the surface properties of lactose used in inhalation products are known to affect their aerosolization performance. [1][2][3] Numerous investigations [4][5][6][7][8][9][10][11][12][13][14] have indicated that the use of engineered lactose particles exhibiting modified surface could lead to more predictable aerosolization performance. However, the availability of lactose powders having improved flow and packing properties is stringent also in capsule and tablet technology.…”

Section: Introductionmentioning

confidence: 99%

The surface roughness of lactose particles can be modulated by wet-smoothing using a high-shear mixer

Ferrari¹,

Cocconi

Bettini

et al. 2004

AAPS PharmSciTech

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The surface morphology of α-lactose monohydrate particles was modified by a new wet-smoothing process performed in a high-shear mixer using solvents. Successive steps of wetting and drying of lactose powders during rolling in the mixer's cylindrical bowl were performed. Smoothed particles were tested for size distribution, flow, and packing. The wet-smoothing process flattened the surface and rounded the edges of lactose particles. In comparison with original lactose, an improvement of powder packing and flow properties was evidenced. When the process was performed in the presence of a ternary agent such as magnesium stearate, the smoothing was improved. The evolution of rugosity during the smoothing process was assessed through a fractal descriptor of SEM picture. Atomic force microscopy and surface area measurements quantified the surface rugosity. A very significant reduction of the rugosity, more remarkable in the presence of magnesium stearate, was measured. This new process of powder wet-smoothing allows the preparation of lactose particles with different degrees of smoothed surface for the control of flow and packing properties and particleparticle interactions.

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“…The use of carrier particles with rougher surfaces was shown to increase [143,158,191,234,[237][238][239][240][241], decrease [21,158,242], or have no significant effect on FPF [243]. Direct proportional relationships were reported between the specific surface area of carrier powders and FPF [244,245], but the reverse trend was also reported [158,246].…”

Section: Surface Propertiesmentioning

confidence: 62%

“…Such tribocharging could have a considerable effect on the blending efficiency of adhesive mixtures [4,117,216]. Several studies related the blending homogeneity of adhesive mixtures for inhalation to an increased level in the overall net-charge [64,217,218]. The electrostatic charge could lead to less dose homogeneity.…”

Section: Electrostatic Chargementioning

confidence: 99%

On the effects of blending, physicochemical properties, and their interactions on the performance of carrier-based dry powders for inhalation — A review

Kaialy

2016

Advances in Colloid and Interface Science

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Blending drug and carrier powders to produce homogeneous drug-carrier adhesive mixtures is a key step in the production of dry powder inhaler (DPI) formulations. Although the blending conditions can result in different conclusions or probably change the outcome of a study entirely if being selected differently, there is a scarcity of data on the influence of blending processes on the physicochemical properties of bulk powder formulations and the follow-on effects on DPI performance. This paper provides an overview of the interactions between variables related to blending conditions (e.g. blending equipment, time, speed and sequence as well as environmental humidity) and powder physicochemical properties (e.g. size distribution, shape distribution, density, anomeric composition, electrostatic charge, surface, and bulk properties), and their effects on the performance of adhesive mixtures for inhalation in terms of drug content homogeneity, drug-carrier adhesion, and drug aerosolisation behaviour. The relevance of carrier payload, batch size and segregation was also discussed. Challenges and future directions were identified. This review therefore contributes towards a better understanding of the blending process, powder physicochemical properties, and their interlinked effects on the fundamental understanding of adhesive mixtures for inhalation. The knowledge gained is essential to ensure optimum blending and thereby controlled functionality of DPIs.

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Immobilization of fine particles on lactose carrier by precision coating and its effect on the performance of dry powder formulations

Cited by 48 publications

References 14 publications

Particle Engineering for Pulmonary Drug Delivery

Particle Engineering for Pulmonary Drug Delivery

The surface roughness of lactose particles can be modulated by wet-smoothing using a high-shear mixer

On the effects of blending, physicochemical properties, and their interactions on the performance of carrier-based dry powders for inhalation — A review

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