Immobilization of povidone-iodine on surfaces of silica gel particles and bactericidal property

Gao, Baojiao; Wang, Zhanbin; Liu, Qing; Du, Ruxu

doi:10.1016/j.colsurfb.2010.05.007

Cited by 31 publications

(18 citation statements)

References 20 publications

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“…Such polymers can stabilize iodine through complexation and readily release it and hence, exterminating pathogenic microorganisms like bacteria, virus, and fungi 13 , 14 . The major disadvantages of these types of polymers are the low performance in water medium because of their high solubility and the somewhat complicated synthetic routes that limit their scale-up production 15 , 16 .…”

Section: Introductionmentioning

confidence: 99%

Triazine-based porous organic polymers for reversible capture of iodine and utilization in antibacterial application

Mohan

Al‐Sayah

Ahmed

et al. 2022

Sci Rep

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The capture and safe storage of radioactive iodine (129I or 131I) are of a compelling significance in the generation of nuclear energy and waste storage. Because of their physiochemical properties, Porous Organic Polymers (POPs) are considered to be one of the most sought classes of materials for iodine capture and storage. Herein, we report on the preparation and characterization of two triazine-based, nitrogen-rich, porous organic polymers, NRPOP-1 (SABET = 519 m2 g−1) and NRPOP-2 (SABET = 456 m2 g−1), by reacting 1,3,5-triazine-2,4,6-triamine or 1,4-bis-(2,4-diamino-1,3,5-triazine)-benzene with thieno[2,3-b]thiophene-2,5-dicarboxaldehyde, respectively, and their use in the capture of volatile iodine. NRPOP-1 and NRPOP-2 showed a high adsorption capacity of iodine vapor with an uptake of up to 317 wt % at 80 °C and 1 bar and adequate recyclability. The NRPOPs were also capable of removing up to 87% of iodine from 300 mg L−1 iodine-cyclohexane solution. Furthermore, the iodine-loaded polymers, I2@NRPOP-1 and I2@NRPOP-2, displayed good antibacterial activity against Micrococcus luteus (ML), Escherichia coli (EC), and Pseudomonas aeruginosa (PSA). The synergic functionality of these novel polymers makes them promising materials to the environment and public health.

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Section: Introductionmentioning

confidence: 99%

Triazine-based porous organic polymers for reversible capture of iodine and utilization in antibacterial application

Mohan

Al‐Sayah

Ahmed

et al. 2022

Sci Rep

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“…The elemental analysis of EDX ( Figure S1, supplementary file ) recorded the signal of I beside that of O and C for hydrogel. In FTIR spectral analysis, absorption peak of C=O in PI (at 1627 cm −1 ) and was overlapped with that of Pe@CMP hydrogel [ 51 , 52 ]. Both of micrographs and FTIR spectra confirmed the loading of PI onto the hydrogel.…”

Section: Resultsmentioning

confidence: 99%

Controllable Release of Povidone-Iodine from Networked Pectin@Carboxymethyl Pullulan Hydrogel

Emam

Mohamed

2021

Polymers

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Povidone-iodine (PI) is a common antiseptic reagent which is used for skin infections and wound healing. The control release of PI is quite important to heal the deep and intense wounds. Herein, the preparation of biodegradable pectin@carboxymethyl pullulan (Pe@CMP) hydrogel was carried out and applied for controllable release of PI. CMP was synthesized by interaction of monochloroacetic acid with pullulan at different ratios. The Pe@CMP hydrogel was then prepared by crosslinking of pectin with CMP in presence of glutaraldehyde as cross linker. After carboxymethylation, COOH contents were enlarged to be 24.2–51.2 mmol/kg and degree of substitution was 0.44–0.93. The rheological properties of Pe@CMP hydrogel were enlarged by increment of pectin ratio. Swelling ratio in water (16.0–18.0%) was higher than that of artificial sweat (11.7–13.2%). Pe@CMP hydrogel containing 20% pectin, exhibited the lowest release and 57.7% from PI was released within 360 min. The biological activity of the released PI was monitored to be highly efficient. The kinetic of release was fitted well to the first ordered reaction and Higuchi models. The mechanism of release was explained by the swelling of hydrogel. The networked structure of hydrogel was opened by swelling and PI was released from the outer pores followed by inner pores, achieving the controllable release.

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“…In contrast to conventional antibiotics, the biomaterials sector has witnessed the genesis of various kinds of innovative antimicrobial agents (Regiel‐Futyra et al, ). Materials like peptides (Marr, Gooderham, & Hancock, ; Meher, Sahu, Saini, & Rao, ), zinc/zinc oxide (ZnO) (Bhattacharjee et al, ; Cai et al, ; Raghupathi, Koodali, & Manna, ), N‐halamines (Dong et al, ; Kang et al, ), quaternary ammonium salt (Munoz‐Bonilla & Fernández‐García, ; Timofeeva & Kleshcheva, ) and povidone−iodine (PVP − I 2 ) (Gao, Wang, Liu, & Du, ) have been effectively used to treat surgical site infections (SSI) in orthopedics (Gao et al, ). However, compared with antibiotics and other antibacterial agents, silver (Ag) is recognized as a universal and traditional bactericidal agent that has shown a useful bactericidal effect on a broad spectrum of microbial species over decades (Chernousova & Epple, ).…”

Section: Introductionmentioning

confidence: 99%

Silver (Ag) doped magnesium phosphate microplatelets as next‐generation antibacterial orthopedic biomaterials

et al. 2019

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This article reports for the first time our successful result in the synthesis of antibacterial single‐phase newberyite (NB, MgHPO4.3H2O), an important magnesium phosphate (MgP) bioceramic. The prime novelty lies in the fact that we explore novel MgPs as next‐generation orthopedic biomaterials as opposed to conventional calcium phosphates (CaP). While NB has already shown great promise, unlike its competitor struvite (ST, MgNH4PO4.6H2O), NB is not intrinsically antibacterial. Given the havoc created by surgical site infections (SSI) in orthopedics, it would be worthwhile to explore if antibacterial NB can be synthesized cost‐effectively. To accomplish that central goal, we used silver ion (Ag+) containing precursor solutions and exposed those to microwave irradiation. This action resulted in the rapid synthesis of NB microplatelets. Besides, three other specific objectives are addressed. First, Ag‐doping was optimized to preserve the single‐phase nature for sustained dopant release. Second, Ag+ release kinetics against common infection causing bacterial strains was analyzed. Finally, we inspected for any harmful effect of Ag‐doped NB on MC3T3 preosteoblasts. Interestingly, the single‐phase nature of NB microplatelets can be retained until 2 wt % Ag‐doping and they exhibit good antibacterial and cytocompatible properties. Even though 3 wt % Ag‐doped compositions (composites) were 100% antibacterial; they were cytotoxic.

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Immobilization of povidone-iodine on surfaces of silica gel particles and bactericidal property

Cited by 31 publications

References 20 publications

Triazine-based porous organic polymers for reversible capture of iodine and utilization in antibacterial application

Triazine-based porous organic polymers for reversible capture of iodine and utilization in antibacterial application

Controllable Release of Povidone-Iodine from Networked Pectin@Carboxymethyl Pullulan Hydrogel

Silver (Ag) doped magnesium phosphate microplatelets as next‐generation antibacterial orthopedic biomaterials

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