Immune and Anti-oxidant Functions of Ethanol Extracts of Scutellaria baicalensis Georgi in Mice Bearing U14 Cervical Cancers

Abstract

Background: The objective was to study the effect of Scutellaria baicalensis Georgi ethanol extracts (SBGE) on immune and anti-oxidant function in U14 tumor-bearing mice. Materials and Methods: U14 tumor-bearing mice were randomly divided into eight groups: a control group, a cyclophosphamide (CTX) group, three dose groups of SBGEⅠ (high, medium, low), and three dose groups of SBGEⅡ (high, medium, low). After two weeks, the thymus and spleen weight indices of mice bearing U14 cervical cancer were calculated. Enzyme linked immunosorbent assays (ELISA) was used to determine the levels of serum IL-2, TNF-α, IL-8, and PCNA. MDA activity and SOD activity in plasma were measured with detection kits. Results: In the SBGE groups, thymus weight and spleen weight indices of U14 tumor-bearing mice were significantly higher than in the control group or CTX group (p<0.05). Compared to control group, the levels of serum IL-2 and TNF-α in U14 tumor-bearing mice increased significantly, whereas the contents of serum IL-8 and PCNA decreased (p<0.05). The activity of SOD increased with the growing dose of SBGE, while the activity of MDA decreased significantly in the higherdose groups of SBGE. Conclusions: These findings suggested that SBGE, especially at high dose, 1000 mg/kg, showed significant immune and anti-oxidant effects infU14 tumor-bearing mice, which might be the mechanisms of SBGE inhibition of tumor growth.

Antitumor effects and mechanism of n-butanol fraction from aril of Torreya grandis in H22 mice

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Synergistic cytotoxic effects of a combined treatment of a Pinellia pedatisecta lipid-soluble extract and cisplatin on human cervical carcinoma in vivo

“…Due to the importance of CDDP chemotherapy for cancer patients, numerous studies have focused on protective strategies to alleviate the side effects of CDDP. Herbal and herbal-derived medicine has been recognized as an attractive approach for cancer therapy with few side effects (21,22). Furthermore, evidence suggests that various herbal medicines have synergistic effects when combined with CDDP by enhancing its toxicity against cancer cells, prolonging the patients' survival time and preventing the side effects of chemotherapy (23–25).…”

Anti-tumor effects of Abnormal Savda Munziq on the transplanted cervical cancer (U27) mouse model

“…The increases in the spleen and thymus indexes reflected enhanced T lymphocyte proliferation and improved immune function. Usually, the anti-tumor effects of Chinese herbal medicine are associated with immune function regulation [25, 26]. According to Chinese cancer research standards, herbal medicine is only considered to be effective as an anti-cancer treatment when the tumor inhibition rate is higher than 30% [27, 28].…”