Immune checkpoint inhibitor‐induced enteritis assessed using capsule endoscopy

Abstract

We performed capsule endoscopy for a patient with immune checkpoint inhibitor‐induced enteritis and found multiple erosions or small ulcers in the small intestine. No reports demonstrated the effectiveness of capsule endoscopy for immune checkpoint inhibitor‐induced gastrointestinal adverse events, and our case suggests that capsule endoscopy may be useful to evaluate immune checkpoint inhibitor‐induced enteritis.

Small bowel villous atrophy due to immune-checkpoint inhibitors: report of two cases and literature review

“…In 10 reports (Table 1), VA was present and developed during therapy with PD/ PD-L1 inhibitors for solid tumours. [16][17][18][19][20][21][22][23][24][25] In the remaining 9 (Table 2), patients developed small bowel involvement other than VA. [26][27][28][29][30][31][32][33][34] Finally, we identified 2 single-centre retrospective case series reporting cases of small bowel involvement. In the first, 2 cases of enteropathy with VA are described and, in the second, 8 cases of coeliac disease associated with ICIs and a further 9 cases of VA related to ICIs with negative tissue transglutaminase antibodies are reported.…”

The Entire Intestinal Tract Surveillance Using Capsule Endoscopy after Immune Checkpoint Inhibitor Administration: A Prospective Observational Study

“…Only a handful of studies have investigated the utility of capsule endoscopy as a screening tool for ICI-induced enterocolitis. Otagiri et al reported in a case report on performing capsule endoscopy for a patient with malignant pleural mesothelioma and revealed enteritis induced by nivolumab [ 29 ]. As a surveillance method for detecting colon polyps, capsule endoscopy has been considered useful due to its greater simplicity and lesser invasiveness than colonoscopy [ 30 ].…”