2021
DOI: 10.1101/2021.08.15.456351
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Immune competence and spleen size scale with colony status in the naked mole-rat

Abstract: Naked mole-rats (NM-R; Heterocephalus glaber) live in multi-generational colonies with a social hierarchy, show low cancer incidence and long life-spans. Here we asked if such extreme physiology might have an immune component. The spleen is the largest lymphoid organ and plays an essential role in response to immunological insults and may participate in combating cancer and slowing ageing. We investigated the anatomy, molecular composition and function of the NM-R spleen using RNA-sequencing and histological a… Show more

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Cited by 2 publications
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“…As the largest immunological organ, spleen plays a role in the inflammatory response. 50 Through the compromised intestinal barrier, LPS activates the TLR4-MyD88dependent pathway in the spleen and the expressions of NF-κB and P38.…”
Section: Discussionmentioning
confidence: 99%
“…As the largest immunological organ, spleen plays a role in the inflammatory response. 50 Through the compromised intestinal barrier, LPS activates the TLR4-MyD88dependent pathway in the spleen and the expressions of NF-κB and P38.…”
Section: Discussionmentioning
confidence: 99%