Immune Complex Assays: Diagnostic and Clinical Application

Phillips, Terry M.; Salinas, Fernando A.

doi:10.3109/10408368909105715

Cited by 9 publications

(5 citation statements)

References 208 publications

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“…The clinical significance of the detection of circulating immune complexes has been linked to many health problems, such as allergies, autoimmune diseases, tumours, cardiac, dermatological, endocrinological, haematological nephrological, neurological, ophthalmological, parasitological, pulmonary, reproductive, transplant and infectious diseases [13].…”

Section: Discussionmentioning

confidence: 99%

“…CIC detection allows the assessment of the immunological status of patients [13,14]. In human medicine, the CIC relationship with many diseases has been demonstrated, e.g., in allergies, autoimmune diseases, cancers, cardiological, dermatological, endocrinological, nephrological, neurological, ophthalmological, pulmonological, reproductive, haematological disorders, infectious and parasitic diseases [13]. Researchers have again come back to CIC analysis in patients with respiratory diseases.…”

Section: Introductionmentioning

confidence: 99%

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The Dynamics of Circulating Immune Complexes in Horses with Severe Equine Asthma

Słowikowska

Bajzert

Miller

et al. 2021

Animals

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Non-invasive diagnostic biomarkers of equine asthma syndrome (EAS) from blood or urine are sought. The aim of this study was to assess the absorbance of circulating immune complexes (CICs) during the exacerbation, remission, and treatment of an asthma episode and assess the potential usefulness of CIC levels in the diagnosis and monitoring of the disease. The control group, asthma group, and treated asthma group each contained six horses. Following an initial examination and group classification, the horses were kept in a dusty environment for seven days and then moved to an asthma-friendly environment for three weeks (the treated group received injections of glucocorticoids). Blood was collected at baseline and on the 1st, 2nd, 3rd, 7th, 14th and 30th days. CIC was measured using the modified Haskova method. The time points did not show significant statistical differences. There was a significant decrease in CIC in the treated group, and a significant increase in CIC in the non-treated group on day 30. CIC did not support the EAS diagnosis, although it may help in monitoring patients. To the best of the authors’ knowledge, this is the first study to analyse the dynamics of CIC during environmental challenge, remission, and treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Dynamics of Circulating Immune Complexes in Horses with Severe Equine Asthma

Słowikowska

Bajzert

Miller

et al. 2021

Animals

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“…The nature of Ig-containing complexed material has not been fully characterized in any infection but may represent Ag-Ab or Ab-Ab interactions [36]. Indeed, such is their ubiquity that circulating ICs have even been used as diagnostic markers of infectious disease [43]. In addition to the increase in specific Ab, many bacterial, viral and the majority of parasitic infections provoke a nonspecific hypergammaglobulinemia, particularly IgG and IgM [25,29,42,44].…”

Section: Opinionmentioning

confidence: 99%

Do regulatory antibodies offer an alternative mechanism to explain the hygiene hypothesis?

Mekhaiel

Daniel-Ribeiro

Cooper

et al. 2011

Trends in Parasitology

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The 'hygiene hypothesis', or lack of microbial and parasite exposure during early life, is postulated as an explanation for the recent increase in autoimmune and allergic diseases in developed countries. The favored mechanism is that microbial and parasite-derived products interact directly with pathogen recognition receptors to subvert proinflammatory signaling via T regulatory cells, thereby inducing anti-inflammatory effects and control of autoimmune disease. Parasites, such as helminths, are considered to have a major role in the induction of immune regulatory mechanisms among children living in developing countries. Invoking Occam's razor, we believe we can select an alternative mechanism to explain the hygiene hypothesis, based on antibody-mediated inhibition of immune responses that may more simply explain the available evidence.

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“…Many studies of the presence of antituberculotic antibodies in the serum have produced inconsistent results because of a high proportion of false-positive results [6,11–14]. Some authors note the high levels of circulating immune complexes (CIC) in the serum of patients with tuberculosis [7,10,14,15]. The initial work on this issue appeared in the 1980s [16].…”

Section: Introductionmentioning

confidence: 99%

Research on the occurrence of Mycobacterium tuberculosis antigens in the circulating immune complexes, isolated from serum of patients with tuberculosis

Przybylski

Gołda

2014

Med Sci Monit

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BackgroundTuberculosis is one of the most dangerous infectious diseases and has among the highest mortality rates of all infectious diseases. There are 9 million cases of active tuberculosis reported annually; however, an estimated one-third of the world’s population is infected with Mycobacterium tuberculosis and remains asymptomatic. Despite the great progress in its diagnosis and treatment, tuberculosis is still a serious health and social problem. The contact between the immune system and Mycobacterium tuberculosis initiates cell-specific (Th1) and humoral-specific (Th2) responses. Many studies about the presence of antituberculotic antibodies in the serum have produced inconsistent results because of a high proportion of false-positive or false-negative results. The purpose of this study was to confirm whether circulating immune complexes (CIC) isolated from the serum of patients with tuberculosis are accompanied by antigenic proteins typical of Mycobacterium tuberculosis.Material/MethodsWe assayed serum samples from 42 patients with tuberculosis. The control group consisted of the sera samples taken from 45 healthy subjects. The immunochemical analysis of dissociated immune complexes using the dot blot method demonstrated positive reaction on the presence of Mycobacterium tuberculosis antigens in all patients with tuberculosis.ResultsAll patients with tuberculosis demonstrated a high serum concentration of CIC protein. The mean serum concentration of CIC protein was significantly higher in patients than in controls: 0.081 g/l in the control group and 0.211 g/l in the tuberculosis patients.ConclusionsThe analysis of CIC suggests that it may be a helpful test for patients with tuberculosis because of its quickness, simplicity of the idea, and limited invasiveness.

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Immune Complex Assays: Diagnostic and Clinical Application

Cited by 9 publications

References 208 publications

The Dynamics of Circulating Immune Complexes in Horses with Severe Equine Asthma

The Dynamics of Circulating Immune Complexes in Horses with Severe Equine Asthma

Do regulatory antibodies offer an alternative mechanism to explain the hygiene hypothesis?

Research on the occurrence of Mycobacterium tuberculosis antigens in the circulating immune complexes, isolated from serum of patients with tuberculosis

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