Immune Dysfunction as a Cause and Consequence of Malnutrition

Bourke, Claire D.; Berkley, James A.; Prendergast, Andrew J.

doi:10.1016/j.it.2016.04.003

Cited by 515 publications

(451 citation statements)

References 98 publications

(276 reference statements)

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“…In a clinical study, oxidative stress has been shown to be negatively and significantly associated with nutritional status . Furthermore, undernourishment has been well shown to be associated with impairment of immune function of the host . Some micronutrients are possibly of importance in protecting against reactivated TB, through anti‐oxidative and other mechanisms .…”

Section: Future Research Directions Regarding Tb In Older Peoplementioning

confidence: 99%

“…82 Furthermore, undernourishment has been well shown to be associated with impairment of immune function of the host. 83 Some micronutrients are possibly of importance in protecting against reactivated TB, through anti-oxidative and other mechanisms. 84,85 Interestingly, obesity appears to protect against development of TB.…”

Section: Future Research Directions Regarding Tb In Older Peoplementioning

confidence: 99%

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Epidemiological, clinical and mechanistic perspectives of tuberculosis in older people

et al. 2018

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With the ageing population globally, tuberculosis (TB) in older people becomes a major clinical and public health challenge. In many Asian countries, especially those located in the eastern and southeastern parts of the continent, geriatric TB is a significant problem. TB in the older patients is more difficult to diagnose in the early course of disease, and has poorer treatment outcomes, largely as increased failure and death. More drug-induced adverse reactions are also experienced by this population during TB therapy. Oxidative stress and mitochondrial dysfunction are now well recognized to be associated with the ageing process, and it is likely that the cellular and molecular perturbations interact inextricably with the immunological dysfunction biophysiologically inherent to ageing. These underlying mechanistic bases putatively contribute to the development of TB in the geriatric population and worsen the disease outcomes, especially when the TB is compounded by co-morbid conditions such as smoking and diabetes mellitus. Unravelling these mechanisms further would yield knowledge that might potentially help to prevent reactivated TB in older people, and also to better manage the established disease with drug regimens and other new therapeutic strategies. In addition, addressing the social elements associated with geriatric TB is also imperative in the relief of individual patient suffering and improvement of overall disease control.

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Section: Future Research Directions Regarding Tb In Older Peoplementioning

confidence: 99%

Section: Future Research Directions Regarding Tb In Older Peoplementioning

confidence: 99%

Epidemiological, clinical and mechanistic perspectives of tuberculosis in older people

et al. 2018

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“…Each of these early exposures can have lasting effects on physical and mental health, including altered stress response (Puetz et al, 2016; Rosen et al, 2004); increased inflammatory factors (Bourke, Berkley, & Prendergast, 2016; Coelho et al, 2014), and increased risk for cognitive and mental health problems (Galler et al, 2012; 2013; Young & Widom, 2014). In addition, they likely share some of the same risk factors, such as strained family economic resources (Brown et al, 1998; Walker et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Relationship between infant malnutrition and childhood maltreatment in a Barbados lifespan cohort

Hock

Bryce

Waber

et al. 2017

Vulnerable Children and Youth Studies

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Childhood malnutrition and maltreatment (abuse, neglect) are both prevalent, particularly in resource-limited settings. Despite their known negative impact on child development, there is surprisingly little research documenting their interrelationships. To address this gap, we administered the Childhood Trauma Questionnaire-Short Form (CTQ-SF), a retrospective structured self-report of childhood abuse and neglect, in a Barbadian cohort of 77 adult survivors of infant malnutrition, limited to the first year of life, and 62 healthy controls from the same classrooms and neighborhoods (mean age ± SD = 43.8±2.3 years). This cohort has been followed since birth. Using factor analysis and comparison with archival data addressing similar constructs, we found evidence for reliability and validity of the CTQ-SF in this population. Linear regression analyses, with and without adjusting for childhood household standard of living at three childhood ages, revealed that a history of infant malnutrition was significantly associated with increased levels of self-reported physical neglect in childhood, and, to a somewhat lesser degree, emotional neglect. This study highlights the co-occurrence of infant malnutrition and self-reported maltreatment in childhood in Barbados, with potential public health implications.

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“…In fact, it is known that nutritional changes may result in related immune parameters alterations [60], for instance, thymus relative weight [61,62], increased chronic inflammation susceptibility and recurrent infections [63].…”

Section: Discussionmentioning

confidence: 99%

Toxic and Immunotoxic Evaluation of Ketamine and/or Ethanol in Rats During 28 Days

Mendes

Simon

Hueza

2017

Int J Pharm Pharm Sci

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Objective: Studies have shown that ketamine (K) and ethanol (E) have immunomodulatory activity; however, few studies were performed with concomitant treatments. Thus, we evaluated the toxic and immunotoxic effects of this association.Methods: Wistar rats were distributed into four groups (n=8/group), each receiving one of the following treatments, for 28 d: K group (15 mg/kg of ketamine, intraperitoneally); E group [1.0 ml of ethanol 10% (approximately 0,08g/rat), gavage]; KE group, receiving both treatments; and Control (Co) group, receiving only vehicles. On day 29, animals were euthanized for biochemical, hematological, histopathological and immunological evaluation. Results:Although the experimental conditions did not elicit changes on immune parameters, some biochemical alterations were detected in the different groups. Even in the absence of nutritional and histopathological changes, or renal and hepatic markers that could indicate tissue damage, a reduction on alkaline phosphatase levels in rats from K and KE groups was observed. Moreover, changes in lipid markers [cholesterol, triglycerides and high-density lipoproteins (HDL)] were found in the different groups studied, suggesting that K and E could promote a synergic/antagonistic effect. Conclusion:In conclusion, despite biochemical alterations promoted by K and E, associated or not, the doses here employed did not promote immunotoxic effects on rats treated for 28 d. (response to the suggestion in the end of the paper).

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Immune Dysfunction as a Cause and Consequence of Malnutrition

Cited by 515 publications

References 98 publications

Epidemiological, clinical and mechanistic perspectives of tuberculosis in older people

Epidemiological, clinical and mechanistic perspectives of tuberculosis in older people

Relationship between infant malnutrition and childhood maltreatment in a Barbados lifespan cohort

Toxic and Immunotoxic Evaluation of Ketamine and/or Ethanol in Rats During 28 Days

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