Immune Dysfunction in Trauma

Napolitano, Lena M.; Faist, Eugen; Wichmann, Matthias W.; Coimbra, Raúl

doi:10.1016/s0039-6109(05)70084-0

Cited by 86 publications

(48 citation statements)

References 165 publications

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“…Surgery elicits a stress response of both endocrine and inflammatory origin. 6,7 In this study, the key proinflammatory cytokines IL-6 and IL-8 were clearly increased as a consequence of the trauma of surgery. IL-6 is secreted by different cells (primarily monocytes and macrophages) and induces an acute-phase response.…”

Section: Discussionmentioning

confidence: 55%

“…6 Increased levels of cytokines that occur in the systemic inflammatory response trigger interactions with endothelial cells and result in vasodilation and increased microvascular permeability. [7][8][9] Vascular endothelial growth factors (VEGFs), which stimulate growth of "leaky"microvessels, 9 -13 are widely studied in cancer research. VEGFs are key molecules in the control of angiogenesis, vasodilation, and increased microvascular permeability in vivo.…”

Section: Introductionmentioning

confidence: 99%

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Vascular endothelial growth factor (VEGF) in plasma increases after hip surgery

Svensén

2004

Journal of Clinical Anesthesia

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Section: Discussionmentioning

confidence: 55%

Section: Introductionmentioning

confidence: 99%

Vascular endothelial growth factor (VEGF) in plasma increases after hip surgery

Svensén

2004

Journal of Clinical Anesthesia

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“…Surgical stress and other types of injury induce systemic inflammation, which is mediated by cytokines such as IL-6, IL-1beta, and TNF-alpha [16,17]. Excessive pro- duction of these cytokines, especially IL-6, is associated with postoperative infectious complications after major surgery for cancer [18].…”

Section: Discussionmentioning

confidence: 99%

The Impact of Preoperative Enteral Nutrition Enriched with Eicosapentaenoic Acid on Postoperative Hypercytokinemia after Pancreatoduodenectomy: The Results of a Double-Blinded Randomized Controlled Trial

et al. 2018

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Aims: To investigate whether preoperative enteral diets enriched in eicosapentaenoic acid (EPA) supplements could reduce the incidence of hypercytokinemia after pancreatoduodenectomy (PD) in a double-blinded randomized controlled trial. Methods: Patients with resectable periampullary cancer were randomized into either the control group or the treatment group. Patients in the treatment group received oral supplementation (600 kcal/day) containing EPA for 7 days before surgery. Patients in the control group received isocaloric isonitrogenous standard nutrition (600 kcal/day) without EPA for 7 days before surgery. The primary endpoint was postoperative serum concentrations of interleukin-6 (IL-6). The secondary endpoints were the postoperative nutritional status and the incidence of postoperative infectious complications. Results: Twenty-four patients were enrolled in the present study. After exclusion, 20 patients (control group, n = 9; treatment group, n = 11) were analyzed. There were no significant differences in the curves for the serum concentration of IL-6 (p = 0.68) or the incidence of infectious complications between the 2 groups (control group: 78%, treatment group: 55%, p = 0.37). Conclusions: The results of a double-blinded randomized controlled trial indicated that preoperative immunonutrition had no marked impact on the rates of postoperative hypercytokinemia or infectious complications after PD.

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“…The early release of pro-inflammatory cytokines such as TNF-a, IL-1b, and IL-6 contribute to the development of multiple organ dysfunction/failure syndrome [13][14][15]. Experimental and clinical studies have shown the effects of agents such as that suppress the early inflammatory response [16].…”

Section: Introductionmentioning

confidence: 99%

The prognostic importance of serum IL-1β, IL-6, IL-8 and TNF-α levels compared to trauma scoring systems for early mortality in children with blunt trauma

2007

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The purpose of the present study was to determine whether a correlation exits between the main trauma scoring systems and the activation of inflammatory cells and mediators such as interleukin-(IL-) 1beta, IL-6, IL-8 and tumor necrosis factor alpha (TNF-alpha) after trauma, and moreover to assess if any of these can be used to predict the outcome in patients under care at a trauma center. Forty-seven children (37 boys, 10 girls) presenting with blunt trauma, were evaluated by an analysis of the relationship between overall mortality and potential risk factors. Admission data, including serum IL-1beta, IL-6, IL-8, TNF-alpha, pediatric trauma score (PTS), and injury severity score (ISS), were collected and analyzed. In descriptive statistics for independent variables, some prognostic factors such as IL-8 (P = 0.04), and ISS (P = 0.004) were significant in their relationship to mortality. In the univariate statistical analysis some other risk factors such as IL-8 (P = 0.004), >20 TNF-alpha (P = 0.04), and ISS (P = 0.007) were significant in their relationship to mortality. The relative risk of developing mortality was higher than two for each of the following risk factors: >10 ages, >25 IL-6, 10-20 TNF-alpha, >20 TNF-alpha, PTS 15. There was a positive correlation between IL-8 (r = 0.31, P = 0.33), ISS (r = 0.31, P = 0.0001), and mortality. There was also a correlation with ISS and IL-8 (r = 0.32, P = 0.02). ISS, and the serum IL-8 level are the most important determinants of clinical outcome in critically injured patients. A correlation exits between IL-8 and mortality and between ISS and IL-8.

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Immune Dysfunction in Trauma

Cited by 86 publications

References 165 publications

Vascular endothelial growth factor (VEGF) in plasma increases after hip surgery

Vascular endothelial growth factor (VEGF) in plasma increases after hip surgery

The Impact of Preoperative Enteral Nutrition Enriched with Eicosapentaenoic Acid on Postoperative Hypercytokinemia after Pancreatoduodenectomy: The Results of a Double-Blinded Randomized Controlled Trial

The prognostic importance of serum IL-1β, IL-6, IL-8 and TNF-α levels compared to trauma scoring systems for early mortality in children with blunt trauma

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