Immune dysregulation and pathogenic pathways mediated by common infections in rheumatoid arthritis

Salehi, Shima; Dezfouli, Seyedeh Mahsa Mahmoudinezhad; Azadeh, Hossein; Khosravi, Shaqayeq

doi:10.1007/s12223-023-01036-0

Cited by 14 publications

(7 citation statements)

References 126 publications

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“…Based on other published studies [12][13][14][15][16][17][18], we included confounding factors that could in uence the relationship between HSV-1/2 infection and RA as covariates. The covariates included age, gender, race, education level, marital status, smoking status, alcohol status, diabetes, hyperlipidemia and hypertension.…”

Section: Covariatesmentioning

confidence: 99%

“…Furthermore, bacterial and viral infections also play a signi cant role in the etiology of RA, commonly reported agents include p.gingivalis, prevotella species, Epstein-Barr virus (EBV), cytomegalovirus (CMV), parvovirus B19, rubella virus, mycoplasma, Proteus mirabilis, Escherichia coli, hepatitis B/C virus, Borrelia burgdorferi (Lyme's disease), Chikungunya virus, human papillomavirus (HPV) are considered to be associated with RA [6][7][8][9][10][11][12]. And the reported possible mechanism of how infection affects RA include the molecular mimicry theory, accelerate the progression of autoimmune disorders, combined with other factors and immunological sensitivity to infection combined with a lack of resistance to self-antigens these four theories [13].…”

Section: Introductionmentioning

confidence: 99%

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Association between Herpes simplex virus type1/2 infection and rheumatoid arthritis risk among adults in NHANES, 2001-2016.

Zeng,

Liu,

Luo

et al. 2023

Preprint

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Objectives: To explore the Association between human herpes simplex virus(HSV) type 1 or type 2 infection and the risk of rheumatoid arthritis(RA), and what is this relationship. Methods: We evaluated the associations of HSV-1/2 antibody levels with the risk of RA among U.S. adults from the National Health and Nutrition Examination Survey (NHANES), 2001-2016. We developed four independent multivariate logistic regression models to evaluate the association between HSV-1/2 infection and the risk for RA the population. Results: Finally, we analyzed 1346, 1343 and 1343 subjects, respectively. In all models, HSV-1 infection significantly reduced the prevalence of RA in adults aged 18-49 years, with the lowest odds ratio (OR) (after weighting: OR 0.73, 95% CI 0.72, 0.73), whereas HSV-2 infection was positively associated with an increased prevalence of RA in population aged 18-49 years, with the highest value of the OR (after weighting: OR 1.69, 95% CI 1.69, 1.69), after correction for confounders such as age, sex, race, education level, marital status, smoking,alcohol, diabetes, hypertension, hyperlipidemia and missing values or removing the effect of the interaction between the two viruses, these connections still exist. Conclusion: In summary, these findings indicated that HSV-1 infection can reduce the prevalence of RA in adults, while HSV-2 infection is positively associated with the prevalence of RA in adults. However, our findings need more powerful to prove these associations through rigorously designed prospective studies.

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Section: Covariatesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association between Herpes simplex virus type1/2 infection and rheumatoid arthritis risk among adults in NHANES, 2001-2016.

Zeng,

Liu,

Luo

et al. 2023

Preprint

View full text Add to dashboard Cite

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“…Numerous scholarly publications have been published regarding the possible significance of IgG4 concentration, encompassing both raised and lowered serum levels, in the context of Sjogren's disease. [5,6] IgG4 has the potential to imitate the activity of rheumatoid factor (RF) by engaging with other IgGs. However, it should be noted that IgG4 binds to the constant domains of these Igs, whereas a conventional RF operates through variable domains.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The role of IgG4 in systemic lupus erythematosus: Implications for pathogenesis and therapy

Liu,

Wang,

et al. 2024

J Biochem & Molecular Tox

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Immunoglobulin (Ig) G4 has a distinctive nature, and its involvement in autoimmune disorders is a subject of ongoing debate and uncertainty. A growing body of evidence indicates that IgG4 may play a pathogenic role in the development of systemic lupus erythematosus (SLE). The IgG4 autoantibodies have the capability to bind autoantigens in a competitive manner with other Ig classes, thereby forming immune complexes (ICs) that are noninflammatory in nature. This is due to the low affinity of IgG4 for both the Fc receptors and the C1 complement molecule, which results in a diminished inflammatory response in individuals with SLE. The present study aims to elucidate the significance of IgG4 in SLE. The present discourse pertains to the nascent and suggested modalities through which IgG4 might participate in the pathogenesis of SLE and the potential ramifications for therapeutic interventions in SLE.

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“…Joints that are impacted are swollen and painful, the cervical spine is the only part of the axial skeleton that is often spared, it's typical to feel lousy, stiff in the morning, and worn out (4) . The susceptibility to rheumatoid arthritis (RA) appears to be influenced by a complex interplay between a specific immune response to various environmental factors and a favorable genetic predisposition, infections are believed to play a significant role in triggering autoimmune diseases, often associated with specific microorganisms among the identified environmental factors (5) . RA is characterized by synovial inflammation, swelling (hyperplasia), the production of autoantibodies such as RF and aACPA, as well as the destruction of cartilage and bone (leading to deformity).…”

mentioning

confidence: 99%

Association of Interleukin-17 and ACCP levels with Rheumatoid arthritis patients and Control Groups

Jassim,

Al-Turaihi

2023

KMJ

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Background: Rheumatoid arthritis (RA) represents the prevailing form of chronic inflammatory polyarthritis, characterized by an autoimmune response directed against citrullinated antigens and subsequent synovial joint destruction. The susceptibility to RA appears to be influenced by a complex interplay between a specific immune response to various environmental factors and a favorable genetic predisposition. IL-17 Association with Diseases found to be elevated in various chronic inflammatory conditions including RA especially in cases resistant to anti-TNF therapy. Aim : To investigate the value of IL-17 and ACCP levels with study groups as well as the association of chronic periodontal disease as an environmental risk factor of RA. Methods : This case-control study involved a total of 140 participants were enrolled, with 70 individuals meeting specific criteria and serological testing confirming their RA diagnosis, while the remaining 70 served as healthy controls.The study involved the collection of blood samples from the participants. Various measurements and tests were conducted, including the assessment of disease activity using the Disease Activity Score (DAS28-ESR) and erythrocyte sedimentation rate (ESR), detection of RF through latex agglutination, quantification of anti-cyclic citrullinated peptide (ACCP) and interleukin-17 (IL-17) levels via enzyme-linked immunosorbent assay (ELISA). Results : RA patients exhibited substantially higher values for ESR, RF, ACCP compared to the control group. Also IL-17 substantially higher values for RA patients Notably, the p-values for ESR, ACCP, and IL-17 were 0.0001, 0.02, and 0.0001, respectively, indicating strong statistical significance. patients who had gum problems were 43(61.4 %) while the control group was 9 (12.5%) had a gum problem Statistically, parameter had significant differences (p.value=0.0001).

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Immune dysregulation and pathogenic pathways mediated by common infections in rheumatoid arthritis

Cited by 14 publications

References 126 publications

Association between Herpes simplex virus type1/2 infection and rheumatoid arthritis risk among adults in NHANES, 2001-2016.

Association between Herpes simplex virus type1/2 infection and rheumatoid arthritis risk among adults in NHANES, 2001-2016.

The role of IgG4 in systemic lupus erythematosus: Implications for pathogenesis and therapy

Association of Interleukin-17 and ACCP levels with Rheumatoid arthritis patients and Control Groups

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