Immune escape strategies of Pseudomonas aeruginosa to establish chronic infection

Marzhoseyni, Zeynab; Mousavi, Mohammad Javad; Saffari, Mahmood; Ghotloo, Somayeh

doi:10.1016/j.cyto.2023.156135

Cited by 6 publications

(5 citation statements)

References 111 publications

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“…Pyocyanin can increase infectivity and negative effects of P. aeruginosa on humans [31]. Moreover, pyocyanin also disrupts intracellular calcium homeostasis and inhibits the growth of epidermal cells, thus increasing the damage to the host [32]. Therefore, reducing the expression of pyocyanin is an effective approach for treating P. aeruginosa infections.…”

Section: Discussionmentioning

confidence: 99%

Screening and Metabolomic Analysis of Lactic Acid Bacteria-Antagonizing Pseudomonas aeruginosa

Chen

Xie

et al. 2023

Foods

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Pseudomonas aeruginosa is a conditional Gram-negative pathogen that produces extracellular virulence factors that can lead to bloodstream invasion, severely harm tissues, and disseminate bacteria, ultimately leading to various diseases. In this study, lactic acid bacteria (LAB) with strong antagonistic ability against P. aeruginosa were screened, and the regulatory mechanism of LAB against P. aeruginosa was evaluated. The results showed that the three selected LAB strains had strong inhibition ability on the growth, biofilm formation, and pyocyanin expression of P. aeruginosa and a promoting effect on the expression of autoinducer-2. Among them, Lactipantibacillus plantarum (Lp. plantarum) LPyang is capable of affecting the metabolic processes of P. aeruginosa by influencing metabolic substances, such as LysoPC, oxidized glutathione, betaine, etc. These results indicate that LPyang reduces the infectivity of P. aeruginosa through inhibition of its growth, biofilm formation, pyocyanin expression, and regulation of its metabolome. This study provides new insights into the antagonistic activity of Lp. plantarum LPyang against P. aeruginosa.

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Section: Discussionmentioning

confidence: 99%

Screening and Metabolomic Analysis of Lactic Acid Bacteria-Antagonizing Pseudomonas aeruginosa

Chen

Xie

et al. 2023

Foods

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“…The K. pneumoniae biofilm matrix consists of proteins, DNA, exopolysaccharides, and lipopeptides . Biofilm-mediated growth helps bacteria to evade the attack of immune cells and antimicrobial agents . Further, research has demonstrated that eDNA (extracellular DNA) regulates biofilm development in S. aureus.…”

Section: Biofilms: Fundamental Perspectivementioning

confidence: 99%

“… 64 Biofilm-mediated growth helps bacteria to evade the attack of immune cells and antimicrobial agents. 65 Further, research has demonstrated that eDNA (extracellular DNA) regulates biofilm development in S. aureus. ( 66 , 67 ) The eDNA is responsible for the strengthening of S. aureus biofilms, and DNase treatment has been shown to improve the antibiotic susceptibility of biofilms.…”

Section: Biofilms: Fundamental Perspectivementioning

confidence: 99%

Advances in Nanotechnology for Biofilm Inhibition

et al. 2023

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Biofilm-associated infections have emerged as a significant public health challenge due to their persistent nature and increased resistance to conventional treatment methods. The indiscriminate usage of antibiotics has made us susceptible to a range of multidrug-resistant pathogens. These pathogens show reduced susceptibility to antibiotics and increased intracellular survival. However, current methods for treating biofilms, such as smart materials and targeted drug delivery systems, have not been found effective in preventing biofilm formation. To address this challenge, nanotechnology has provided innovative solutions for preventing and treating biofilm formation by clinically relevant pathogens. Recent advances in nanotechnological strategies, including metallic nanoparticles, functionalized metallic nanoparticles, dendrimers, polymeric nanoparticles, cyclodextrin-based delivery, solid lipid nanoparticles, polymer drug conjugates, and liposomes, may provide valuable technological solutions against infectious diseases. Therefore, it is imperative to conduct a comprehensive review to summarize the recent advancements and limitations of advanced nanotechnologies. The present Review encompasses a summary of infectious agents, the mechanisms that lead to biofilm formation, and the impact of pathogens on human health. In a nutshell, this Review offers a comprehensive survey of the advanced nanotechnological solutions for managing infections. A detailed presentation has been made as to how these strategies may improve biofilm control and prevent infections. The key objective of this Review is to summarize the mechanisms, applications, and prospects of advanced nanotechnologies to provide a better understanding of their impact on biofilm formation by clinically relevant pathogens.

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“…These elements bestow distinct characteristics upon the pathogen and play a crucial role in shaping the intensity and nature of the immune response [8,9]. These virulence factors vary between strains, contributing to the variation in clinical manifestations [10,11]. The immune system of the host will be activated starting inflammatory processes and pathways to fight against the pathogen, such as the release of cytokines and oxidative stress, which can also create conditions conducive to damaging host cells [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Bioactive peptides as alternative treatment for Helicobacter pylori infection

Franca-Oliveira,

Hernández-Ledesma,

Martinez-Rodriguez

2024

BCHD

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The infection and chronic inflammatory response generated by Helicobacter pylori is a global health concern. This pathogen is characterized as a major risk factor in the development of gastric cancer and other diseases. Conventional eradication therapies are based on antibiotic regimens and as a consequence there is an increase in antimicrobial resistance of the pathogen strains, besides other potential side effects for the host. Therefore, it is necessary to explore new alternatives. This review delves into the realm of antimicrobial peptides, exploring their efficacy against H. pylori sourced from diverse origins. Furthermore, it sheds light on food-derived peptides exhibiting remarkable biological activity. These peptides exhibit promising effects on biomarkers associated with H. pylori infection, demonstrating anti-inflammatory and antioxidant properties validated through rigorous testing in both cell and animal models. Regarding the anti-inflammatory activity, the peptide VPY derived from soybean and the peptides derived from animal sources such as meat (β-Ala-His), egg (DEDTQAMPFR, DEDTQAMPF, MLGATSL, MSYSAGF, CR, FL, HC, LL, MK) and milk (IPAV) have reported a reduction of the cytokine IL-8, biomarker directly related to H. infection. For the antioxidant activity, peptides derived from milk (EAMAPK, AVPYPQ) and from Spirulina maxima (LDAVNR, MMLDF) have reduced ROS levels and could have a positive effect on the control of H. infection. Food-derived bioactive peptides with an anti-adhesive effect were also discussed. They derive from vegetable sources (corn, pea and wheat) and are capable of interacting with the host cells, interfering the adherence of H. pylori. Food-derived bioactive peptides have potential to avoid and/or mitigate undesired outcomes of infectious diseases due to the possibility of its application in nutraceuticals and food products, resulting in a preventive approach. Keywords: Helicobacter pylori, antibiotic resistance, bioactive peptides, antimicrobial peptides

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Immune escape strategies of Pseudomonas aeruginosa to establish chronic infection

Cited by 6 publications

References 111 publications

Screening and Metabolomic Analysis of Lactic Acid Bacteria-Antagonizing Pseudomonas aeruginosa

Screening and Metabolomic Analysis of Lactic Acid Bacteria-Antagonizing Pseudomonas aeruginosa

Advances in Nanotechnology for Biofilm Inhibition

Bioactive peptides as alternative treatment for Helicobacter pylori infection

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