Immune function did not decline with aging in apparently healthy, well-nourished women

Krause, Deanna; Mastro, Andrea M.; Handte, Gordon; Smiciklas‐Wright, Helen; Miles, Mary P.; Ahluwalia, Namanjeet

doi:10.1016/s0047-6374(99)00070-6

Cited by 43 publications

(34 citation statements)

References 39 publications

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“…1999). However, as regards the non-specific immune response there is no agreement on the effects of age because of conflicting data (Ortega et al 1993a;Kay, 1996;McArthur, 1998;Krause et al 1999). Phagocytic cells such as monocytes or macrophages, which have been relatively neglected as regards their alterations in old age, play a central role in inflammatory and host defense mechanisms because of their ability to ingest and kill microorganisms.…”

Section: Discussionmentioning

confidence: 99%

“…Published results regarding the ingestion capacity are contradictory. Some of these have shown this capacity to be diminished or unchanged in aged subjects (Ginaldi et al 1999;Krause et al 1999). However, most studies have found a greater phagocytic capacity of macrophages during old age (Wustrow et al 1982;Ortega et al 1993b;Kay, 1996;De la Fuente et al 2000b).…”

Section: Discussionmentioning

confidence: 99%

“…The influence of age on these mechanisms of the immune response is not always negative (Ortega et al 1993a) and, specifically, conflicting results have been reported on the functions of phagocytic cells (Johnson et al 1978;McArthur, 1998;Krause et al 1999). Some studies suggest that macrophage function, unlike lymphocyte function, does not decline with age (Makinodan & Kay, 1980;De Ia Fuente et al 2000b), and an increase in the functioning of the monocyte-macrophage system in aged individuals has even been observed (Wustrow et al 1982;Kuroiwa et al 1989;Ortega et al 1993a).…”

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confidence: 99%

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Ageing Modulates some Aspects of the Non‐Specific Immune Response of Murine Macrophages and Lymphocytes

Ortega

Garcı́a

Fuente

2000

Experimental Physiology

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The deterioration of the immune system with ageing, which leads to an increased morbidity and mortality from infections, appears to be related to decreases in specific lymphocyte functions. However, the alteration of non-specific immunity is a more controversial subject. Our purpose was to investigate the age-related changes of different functions of the non-specific immune response in peritoneal macrophages (adherence to tissues, mobility directed to a chemical gradient from an infectious focus or chemotaxis, phagocytosis of foreign agents and destruction of these agents by superoxide anion production) and in lymphocytes (adherence and chemotaxis) from peritoneum, axillary lymph nodes, spleen and thymus. We used young (12 weeks), adult (22 weeks), mature (48 weeks) and old (72 weeks) female BALB/c mice. The adherence capacity of macrophages and lymphocytes was greater in adult and old mice than in young animals. The chemotaxis of macrophages showed higher values in cells from young mice than in those from adult mice, increasing again in macrophages from mature and old animals. A similar behaviour was shown by phagocytosis, which reached its highest values in old animals. Anion superoxide production increased with age and again the highest values were obtained in the oldest mice. Conversely, chemotaxis of lymphocytes was higher in the adult and mature animals than in the young and old animals. We conclude that, although there is a decrease in lymphocyte chemotaxis in old animals, the non-specific immune response of macrophages instead of decreasing, may increase in aged mice with respect to the values seen in adult mice. Experimental Physiology (2000) 85.5, 519-525.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Ageing Modulates some Aspects of the Non‐Specific Immune Response of Murine Macrophages and Lymphocytes

Ortega

Garcı́a

Fuente

2000

Experimental Physiology

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“…Nutritional status was assessed in this investigation because it is known to influence immune function [32] . The assessments consisted of both body mass index (BMI: weight/height 2 ) and serum proteins (total serum proteins, albumin, vitamin B 12 , folic acid, and ferritin).…”

Section: Nutritional Analysesmentioning

confidence: 99%

Healthy Aging Is Associated with Unaltered Production of Immunoreactive Growth Hormone but Impaired Neuroimmunomodulation

Luz

Collaziol

Preissler

et al. 2006

Neuroimmunomodulation

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Background: Both endocrine and immune systems are continuously remodeled during aging. Objective: Here, we investigated to what extent adrenal and somatosenescence are associated reciprocal changes in the immune system during strictly healthy aging. Methods: Forty-six elderly subjects and 33 young adults were recruited according to the health criteria of the SENIEUR protocol. Peripheral blood mononuclear cells were isolated and stimulated in vitro with lipopolysaccharide or phytohemagglutinin to assess the production of immunoreactive growth hormone (GH). Peripheral sensitivity to steroids was assessed in vitroby dexamethasone-, cortisol- or dehydroepiandrosterone (DHEA)-induced inhibition of T-cell proliferation. DHEA and GH levels were measured by radioimmunoassays. Results: Healthy elderly had lower salivary DHEA and serum GH levels (somatosenescence). They presented reduced T-cell sensitivity to dexamethasone but similar cellular sensitivities to cortisol and DHEA. Their cells produced similar levels of immunoreactive GH compared to the cells of young adults. Conclusions: These data indicate that healthy aging is associated with adrenal and somatosenescence as well as impaired neuroendocrine immunoregulation at the level of the lymphocyte. In addition, somatosenescence may not be associated with a reciprocal decline in immunoreactive GH.

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“…It was reported that antigenspecific secretory immunoglobulin A titer in the intestinal lumen declined in senescent animals (Koga et al, 2000). Some studies have also reported that reduced bioavailability of key conditionally essential nutrients might limit immune response in aging (CunninghamRundles, 2004) and that well-nourished elderly people appear to have less significant or minimal changes in immune response (Krause et al, 1999).…”

Section: Age-related Changes In Intestine Intraepitherial Lymphocyte mentioning

confidence: 99%

Proliferation and Differentiation of Hematopoietic Cells and Preservation of Immune Functions

Hayashi¹

2012

Blood Cell - An Overview of Studies in Hematology

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Immune function did not decline with aging in apparently healthy, well-nourished women

Cited by 43 publications

References 39 publications

Ageing Modulates some Aspects of the Non‐Specific Immune Response of Murine Macrophages and Lymphocytes

Ageing Modulates some Aspects of the Non‐Specific Immune Response of Murine Macrophages and Lymphocytes

Healthy Aging Is Associated with Unaltered Production of Immunoreactive Growth Hormone but Impaired Neuroimmunomodulation

Proliferation and Differentiation of Hematopoietic Cells and Preservation of Immune Functions

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